The aeolian sedimentation record of the Thar desert

A review of the aeolian sedimentary record of the Thar desert is presented. This includes a regional survey of the major dune forms, their genesis and their relationship to climate and other regional landforms. A key aspect of this work is the chronometry of the dunes using luminescence methods. Luminescence dating of sand has enabled quantification of the duration of the phases of sand aggradation and quiescence, time scales of dune migration and the dating of pedogenic carbonates. We demonstrate that the conventional wisdom of synchronicity of dune aggradation with glacial epoch is not true in the context of Thar sands and here only a short durationwindow of opportunity existed for dune aggradation. Luminescence ages further suggest that this window occurred during a transitional climatic regime from glacial to interglacial about 4-10 ka after the glacial epoch. Other inferences included are that: • the aeolian activity in the Thar began over > 150 ka, resolving that Thar is not of anthropogenic origin as suggested previously; • the present spatial extent of the aeolian activity in the Thar is in a contracted stage compared to that in the geological past, which refutes the arguments on its rapid north-eastward expansion; • the current dune migration rates in areas of significant human-induced disturbances are much higher than during the geological past; • the monsoon activity in the Thar varied significantly, from being minimal during the isotopic marine stages 4 and 2 to being close to the present during stage 3; • on shorter time scales the dune activities correlated with the lacustrine records of the region with a phase difference of a few centuries and a periodicity of ~1500 years; • the sand aggradation climate in the southern margin in Gujarat gradually shrank northwards such that in general dunes older than 10 ka are seen in the extreme southern margin and dunes younger than 2ka ages occur mostly in the western part of Rajasthan

A survey of some new approaches in maximum age limit and accuracy of luminescence application to archaeological chronometry

This article does not have an abstract

A feasibility study of dating Indo-Gangatic alluvium using thermoluminescence and infrared-stimulated luminescence techniques

Results of a successful maiden attempt to date the Indo-Gangetic alluvium using the luminescence dating technique are presented. The low equivalent dose for the surface sample indicates that these samples had experienced a solar resetting of geologically acquired luminescence. The infrared stimulated luminescence ages on other terraces range from ~ 2 to 15 ka and are stratigraphically consistent

Thermoluminescence dating of pottery from Sringaverapura - a Ramayana site

The first thermoluminescence (TL) dates of pottery from aRamayana associated site are reported. The TL dates for pre-NBPW Black-Slipped Ware levels are 730 and 765 B.C., while radiocarbon date takes the earliest Black Slipped Ware level (for which no TL dates are available) to 905 B.C. (uncorrected). For the OCW level, three TL dates are available which range from 1035 B.C. to 875 B.C. The early NBPW period believed to be associated with theRamayana episode will thus be post-750 B.C

Towards a direct dating of fault gouges using luminescence dating techniques-methodological aspects

Results of a study to date neotectonic movements and past seismic events in Himalaya using the thermoluminescence technique are described. The basic assumption of zeroing of geological thermoluminescence during faulting was examined using techniques such as mechanoluminescence and clay mineralogy. Variation of the luminescence paleodoses with grain-size and the paleodose of the rocks away from the fault zone were also examined. The results indicate that neotectonic activity took place around 40 ka ago along Nainital and Sleepy Hollow fault, 70 ka ago along the MBT and 60 ka along the Mohand thrust. In conjunction with other evidences from the lacustrine records in the region, phases of regionally extended tectonic activities at about 40 ka and 60 ka are inferred

Molecular Analysis of Disease-Responsive Genes Revealing the Resistance Potential Against Fusarium Wilt (Fusarium udum Butler) Dependent on Genotype Variability in the Leguminous Crop Pigeonpea

Fusarium wilt (FW), caused by Fusarium udum Butler (FU), is among the challenging factors in the production of pigeonpea. Therefore, exploring a superior pigeonpea genotype from landraces or local cultivars through the selection of innate resistance to FW using different biological and molecular approaches, and validating its resistance response, could be an alternative to sustainable crop improvement. Five distinct pigeonpea genotypes, with resistant (ICP2894) and susceptible (ICP2376) controls, were selected on the basis of the incidence percentage of FW, from three different states of India. Among them, the cultivar Richa, which displayed low incidence of FW (10.0%) during the genotype evaluation, was further examined for its innate resistance to FW. Molecular characterization of antioxidant (AO) enzyme [APX and SOD] and pathogenesis-related (PR) protein [CHS and b-1, 3-glucanase] families were performed. The obtained results of reverse transcription-polymerase chain reaction-based expression study and in silico analysis showed a higher level of induction of PR and AO genes, and the strong interaction of their putative proteins with fungal cellobiohydrolase-c protein established their antifungal activity, conferring early plant defense responses to FU in Richa. Our study demonstrated a strong and combinatorial approach involving biological assay, molecular experiments, and in silico analysis to identify a superior pigeonpea genotype that was resistant to FW across a major biogeographic region

Increasing complexity and interactions of oxidative stress in chronic respiratory diseases: An emerging need for novel drug delivery systems

© 2018 Elsevier B.V. Oxidative stress is intensely involved in enhancing the severity of various chronic respiratory diseases (CRDs) including asthma, chronic obstructive pulmonary disease (COPD), infections and lung cancer. Even though there are various existing anti-inflammatory therapies, which are not enough to control the inflammation caused due to various contributing factors such as anti-inflammatory genes and antioxidant enzymes. This leads to an urgent need of novel drug delivery systems to combat the oxidative stress. This review gives a brief insight into the biological factors involved in causing oxidative stress, one of the emerging hallmark feature in CRDs and particularly, highlighting recent trends in various novel drug delivery carriers including microparticles, microemulsions, microspheres, nanoparticles, liposomes, dendrimers, solid lipid nanocarriers etc which can help in combating the oxidative stress in CRDs and ultimately reducing the disease burden and improving the quality of life with CRDs patients. These carriers improve the pharmacokinetics and bioavailability to the target site. However, there is an urgent need for translational studies to validate the drug delivery carriers for clinical administration in the pulmonary clinic

Thermoresponsive Micropatterned Substrates for Single Cell Studies

We describe the design of micropatterned surfaces for single cell studies, based on thermoresponsive polymer brushes. We show that brushes made of poly(N-isopropylacrylamide) grafted at high surface density display excellent protein and cell anti-adhesive properties. Such brushes are readily patterned at the micron scale via deep UV photolithography. A proper choice of the adhesive pattern shapes, combined with the temperature-dependent swelling properties of PNIPAM, allow us to use the polymer brush as a microactuator which induces cell detachment when the temperature is reduced below C

Real-time monitoring in three-dimensional hepatocytes reveals that insulin acts as a synchronizer for liver clock

Resetting the peripheral clock and understanding the integration between the circadian rhythm and metabolic pathways are fundamental questions. To test whether insulin acts as a synchronizer for the hepatic clock by cell-autonomous mechanisms, the phase-resetting capabilities of insulin were investigated in cultured hepatic cells. We provide evidence that three-dimensional (3D) cell culture conditions that preserve the differentiated state of primary hepatocytes sustained the robustness of the molecular clock, while this robustness rapidly dampened under classical monolayer cell culture conditions. Herein, we established a 3D cell culture system coupled with a real-time luciferase reporter, and demonstrated that insulin directly regulates the phase entrainment of hepatocyte circadian oscillators. We found that insulin-deficient diabetic rats had a pronounced phase advance in their hepatic clock. Subsequently, a single administration of insulin induced phase-dependent bi-directional phase shifts in diabetic rat livers. Our results clearly demonstrate that insulin is a liver clock synchronizer

Determining Factors of the Level of Disclosure of Information on Business Combinations with the Entry into Force of the Accounting Standard CPC 15

This paper aimed to investigate information disclosure on business combination transactions that took place in Brazil in 2010, when the Accounting Standard CPC 15 entered into force, and evaluate which were the determining factors of the level of disclosure of information related to it. To evaluate the disclosure level, a disclosure index of business combinations (INDCOMB) was prepared, having the disclosure index developed by Shalev (2009) as a basis. We evaluated, in the light of the literature on disclosure and business combinations, whether the following factors influenced on the disclosure level: acquiring company size, recognized percentage of overprice for expected future profitability in relation to the transaction value, dispersion of capital of the acquiring company, audit firm size, and participation of the acquiring company in American Depositary Receipts (ADRs) programs. The control variables used were listing of the acquiring company in the various segments of BM&FBOVESPA, operation sector, origin (state, private company with national capital or private company with foreign capital), and relative acquired company size in relation to the acquiring company. We analyzed business combination transactions that took place in 2010, reported by 40 open capital companies involved in 76 transactions. We conclude that the audit firm size and the relative acquired company size were factors that influenced on the level of disclosure of information regarding business combinations in 2010. The other factors showed no conclusive results