Improving Student Engagement and Performance in Computing Final Year Projects

There has been a seismic shift in the UK higher education landscape during the last decade. This has been driven by the formation of the Office for Students (OfS) and the introduction of the Teaching Excellence Framework (TEF), where the emphasis has been on programmes offering students higher value when it comes to employability, retention and overall student experience. One of the critical challenges that impact student experience is being able to enhance student engagementwithin a learning environment. Final year individual projects, which are generally unstructured in nature, is a significant contributor to programmes of study, yet remains an area where this problem is exacerbated. In an attempt to address this issue, our earlier work lays the foundation for a teaching & learning framework covering computing final year projects. In this paper, we present an extension to the framework and its implementation in 2016/17 following its first trial run within a Computer Science department at a UK university in 2015/16. We discuss the two implementations in practice and provide operational guidance. A large-scale longitudinal empirical study considering the performance of 625 final year undergraduate students over a period of five years is presented to ascertain the effectiveness of the framework. The study finds a consistent and significant positive impact on both student performance and engagement as a result of the original framework and further gains from the enhancements

An Effective Framework for Enhancing Student Engagement and Performance in Final Year Projects

Over the years, there have been many factors that have influenced the landscape of higher education within the UK. These factors include the rise in tuition fees, the introduction of the Teaching Excellence Framework (TEF) and the formation of Office for Students. Although student performance plays a vital part, another significantly influential key performance indicator that impacts these factors is student experience, which is influenced by positive or negative feedback and engagement. Despite student engagement forming a key part of the learning environment, it is still perceived as one of the weakest aspects when it comes to enhancing the student experience. In this paper, we present the implementation of an innovative, holistic teaching & learning framework for the final year project module trialed within the Department of Engineering and Computing at the University of East London. This project module had been running in different forms since the inception of the undergraduate programmes within the department, however it generally yielded poor and inconsistent evaluation, student experience and engagement. The framework was introduced during the academic year 2015/16, where its evaluation has shown a positive impact on student engagement, performance and experience, compared to the previous year

An Unusual Cause of Seizure in Clinical Practice

Neurocysticercosis (NCC), the infection caused by the larval stage of the tapeworm Taenia solium, is the most common parasitic disease of the nervous system (NS) in humans, where it is the leading cause of late-onset seizures in the endemic areas. Fortunately it is still rare in Bangladesh due to some religious binding in eating pork. Here we present a young man who came to us with Neurocysticercosis as the cause of recurrent seizure and various neurological manifestations

An Effective Framework for Enhancing Student Engagement and Performance in Final Year Projects

Over the years, there have been many factors that have influenced the landscape of higher education within the UK. These factors include the rise in tuition fees, the introduction of the Teaching Excellence Framework (TEF) and the formation of Office for Students. Although student performance plays a vital part, another significantly influential key performance indicator that impacts these factors is student experience, which is influenced by positive or negative feedback and engagement. Despite student engagement forming a key part of the learning environment, it is still perceived as one of the weakest aspects when it comes to enhancing the student experience. In this paper, we present the implementation of an innovative, holistic teaching & learning framework for the final year project module trialed within the Department of Engineering and Computing at the University of East London. This project module had been running in different forms since the inception of the undergraduate programmes within the department, however it generally yielded poor and inconsistent evaluation, student experience and engagement. The framework was introduced during the academic year 2015/16, where its evaluation has shown a positive impact on student engagement, performance and experience, compared to the previous year

A 2-year-old male child with diffuse abdominal pain, mass in the abdomen and red currant jelly stool

This article has no abstract. The first 100 words appear below: A 2-year-old male child, the second issue of non-consanguineous parents, from average socio-economic status hailing from Dinajpur, Bangladesh was attended at Pediatric Surgery outpatient department with the complaints of vague diffuse abdominal pain in the lower right side of abdomen and around the umbilical region for last 3 days. His mother also reported the feeling of a solid mass in the abdomen during dressing of her child. Then, gradually his problems were increasing in nature with several times of nausea, vomiting, and the passage of blood mixed stool three times before his admission

Mesoscopic model for DNA G-quadruplex unfolding

[EN] Genomes contain rare guanine-rich sequences capable of assembling into four-stranded helical structures, termed G-quadruplexes, with potential roles in gene regulation and chromosome stability. Their mechanical unfolding has only been reported to date by all-atom simulations, which cannot dissect the major physical interactions responsible for their cohesion. Here, we propose a mesoscopic model to describe both the mechanical and thermal stability of DNA G-quadruplexes, where each nucleotide of the structure, as well as each central cation located at the inner channel, is mapped onto a single bead. In this framework we are able to simulate loading rates similar to the experimental ones, which are not reachable in simulations with atomistic resolution. In this regard, we present single-molecule force-induced unfolding experiments by a high-resolution optical tweezers on a DNA telomeric sequence capable of adopting a G-quadruplex conformation. Fitting the parameters of the model to the experiments we find a correct prediction of the rupture-force kinetics and a good agreement with previous near equilibrium measurements. Since G-quadruplex unfolding dynamics is halfway in complexity between secondary nucleic acids and tertiary protein structures, our model entails a nanoscale paradigm for non-equilibrium processes in the cell.Work supported by the Spanish Ministry of Economy and Competitiveness (MINECO), grant No. FIS2014-55867, co-financed by FEDER funds. We also thank the support of the Aragon Government and Fondo Social Europeo to FENOL group. Work in J.R.A.-G. laboratory was supported by a grant from MINECO, No. MAT2015-71806-R).Bergues-Pupo, A.; Gutiérrez, I.; Arias-Gonzalez, JR.; Falo, F.; Fiasconaro, A. (2017). Mesoscopic model for DNA G-quadruplex unfolding. Scientific Reports. 7:1-13. https://doi.org/10.1038/s41598-017-10849-2S1137Arias-Gonzalez, J. R. Single-molecule portrait of DNA and RNA double helices. Integr. 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Serotonin regulates prostate growth through androgen receptor modulation

Serotonin regulates prostate growth through androgen receptor modulationAging and testosterone almost inexorably cause benign prostatic hyperplasia (BPH) in Human males. However, etiology of BPH is largely unknown. Serotonin (5-HT) is produced by neuroendocrine prostatic cells and presents in high concentration in normal prostatic transition zone, but its function in prostate physiology is unknown. Previous evidence demonstrated that neuroendocrine cells and 5-HT are decreased in BPH compared to normal prostate. Here, we show that 5-HT is a strong negative regulator of prostate growth. In vitro, 5-HT inhibits rat prostate branching through down-regulation of androgen receptor (AR). This 5-HT's inhibitory mechanism is also present in human cells of normal prostate and BPH, namely in cell lines expressing AR when treated with testosterone. In both models, 5-HT's inhibitory mechanism was replicated by specific agonists of 5-Htr1a and 5-Htr1b. Since peripheral 5-HT production is specifically regulated by tryptophan hydroxylase 1(Tph1), we showed that Tph1 knockout mice present higher prostate mass and up-regulation of AR when compared to wild-type, whereas 5-HT treatment restored the prostate weight and AR levels. As 5-HT is decreased in BPH, we present here evidence that links 5-HT depletion to BPH etiology through modulation of AR. Serotoninergic prostate pathway should be explored as a new therapeutic target for BPH.Projects NORTE-01-0246-FEDER-000012, NORTE-01-0145-FEDER-000013 and NORTE-01-0145-FEDER-000023, supported by the Northern Portugal Regional Operational Program (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) and Bolsa de Investigação GSK Inovação em Urologia 2012info:eu-repo/semantics/publishedVersio