個人の体験に基づくコンテンツの生成と受容に関する研究

関西大

Re-examination of Neg-Raising -Syntactic Evidences and their Problems -

The pair of Neg-Raised and non-Neg-Raised sentences have generally been analyzed as derivationally related by an optional rule, i.e. Neg-Raising, and therefore considered to be paraphrases. In this paper, we will re-examine some different types of syntactic evidences concerning the rule of Neg-Raising and their problems

Predictors of cognitive function in patients with hypothalamic hamartoma following stereotactic radiofrequency thermocoagulation surgery

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138275/1/epi13838.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138275/2/epi13838_am.pd

The Effects of Flooding on Shirakawa Delta Morphology

Floods can significantly alter the morphology of a delta, from inputting increased volumes of sediments to modifying the reach of incoming waves, currents, and other gravity-driven forces occurring within the near shore. Kumamoto experienced flooding in July 2012. This flood event altered the equilibrium profile of the intertidal flat area of the Shirakawa River. This research looks at these modifications and attempts to explain their long-term implications on the overall delta morphology. Data collected over a 30-year period was analyzed and profiles were generated to better analyze and assess the trend in delta morphological changes. Numerical predictions on delta morphology in the presence of gravitydriven sediment transport were applied to investigate the morphological changes related to the flood event. The slope of equilibrium profile is lower and steeper offshore, helping to explain the models created before and after the flood occurred

Flood Risk Management: An Illustrative Approach

Widespread flooding with significant damage in many countries, such as the Philippines in 2013, highlights the ongoing need for effective flood risk management (FRM). This hinges on comprehensive access to and dissemination of information about the elements and the people at risk. Simulations, real-time graphs, and maps illustrate the spatial distribution of flood risks, spatial allocation and dissemination of flood effects, if flood risk reduction measures are not implemented, as well as the benefits to be derived from the effective implementation and maintenance of flood risk management measures not realized. Using precipitation, river water, and tide levels, a real-time monitoring site was set up for the Shirakawa River, Kumamoto, Japan. The data gathered from the July 2012 flood event is used as a demonstrator, illustrating a flood event as well as how to utilize the information provided on this site to determine the future time and possibility of flooding. Additionally, an electronically generated flood hazard map making process is being developed for distribution across Japan. These illustrative approaches can be utilized in cities and communities around the globe

Education in N.Delamare\u27s Traite de la Police : Family and Governmentality in Ancien Regime

This paper is a historical study on the police of family and education at the beginning of the 18th century in France. The police was, according to N.Delamare in his Traite de la police, understood as public laws and orders for regulating and supporting each habitant. His work treated of wide ranges concerning the life of people ; religion, moral, health, food, security, science & liberal arts, commerce, manufacture, servants & domestics, highway and pauper. One of the sources of police was fundamentally the law of nature which consisted of three principles ; religion, self-love and sociability. His thought of general police stood in the connection between self-love and sociability, in other words between privacy and publicity. Duties of police was usefully explained related to the idea of family, as little States and seminar of the State. The family was said to be public as well as particular in the expressions. It proved to be proper for police. It was very important for police to govern and protect marriage, procreation and education. The education meant, in his Traite, the formation of children\u27s mind by correction and recompense founded in the parental authority. The family and education was not only regulated by the society and the State, but gave some models to them in the theory of police. Seminar of the State is significant, where police must view over every life restlessly just as education of children. Namely Delamare\u27s police could be thought of "grand education" of many little States in the State

プロテアソームとミトコンドリアの遺伝学的相互作用の解析

学位の種別: 課程博士審査委員会委員 : (主査)東京大学教授 村田 茂穂, 東京大学教授 新井 洋由, 東京大学教授 一條 秀憲, 東京大学准教授 垣内 力, 東京大学講師 名黒 功University of Tokyo(東京大学

Supersaturated state of diazepam injection following dilution with infusion fluid

BackgroundSignificant precipitation produced by the dilution of diazepam (DZP) injection with an infusion fluid is a great concern for the clinical practice. In this study, the precipitation behavior under different conditions was investigated.MethodFor the sample preparation, DZP injections (Horizon injection and Cercine injection) were diluted with various infusion fluids (Saline, 5% glucose infusion fluid and Soldem 3A) at designated dilution ratios ranging from 1× to 40× (5 mg/mL to 0.125 mg/mL). In addition, to measure the solubility of DZP in the samples, the saturated solutions of DZP were prepared. The DZP concentrations in the samples were measured by high-performance liquid chromatography (HPLC). This study also investigated the precipitate using various analytical methods: infrared microscopy, 1H-NMR, differential scanning calorimetry, and powder X-ray deflection.ResultsFirst, the compatibility of injection with infusion fluids was investigated. Significant precipitation occurred at dilution ratios ranging from 2× to 20×. No significant effects of formulations and infusion fluids on the compatibility were observed. The solubility of DZP was then further investigated. The concentration of DZP dissolved in the admixtures was higher than the solubility. This indicated that DZP existed in a supersaturated state in the infusion fluid admixtures. In the next phase of this study, the precipitate was investigated using various analytical methods. Results showed that the precipitate in infusion fluid admixtures was mostly composed of DZP, but also contained small amounts of the ingredients of DZP injection, such as benzoic acid and benzyl alcohol.ConclusionsThis study clarified details of the precipitation occurring after dilution of DZP injection with infusion fluids. It is worth noting that DZP in an infusion admixture existed in a supersaturated state. These findings offer important insight into the clinical practice of DZP injection

個人の体験に基づくコンテンツの生成と受容に関する研究 [論文要旨及び審査の要旨]

関西大

Ictal direct current shifts contribute to defining the core ictal focus in epilepsy surgery

難治てんかん焦点の新しいバイオマーカー「発作時DC電位」 --国内5施設の共同研究での世界初の成果--. 京都大学プレスリリース. 2022-09-05.Identifying the minimal and optimal epileptogenic area to resect and cure is the goal of epilepsy surgery. To achieve this, EEG analysis is recognized as the most direct way to detect epileptogenic lesions from spatiotemporal perspectives. Although ictal direct-current shifts (icDCs; below 1 Hz) and ictal high-frequency oscillations (icHFOs; above 80 Hz) have received increasing attention as good indicators that can add more specific information to the conventionally defined seizure-onset zone, large cohort studies on postoperative outcomes are still lacking. This work aimed to clarify whether this additional information, particularly icDCs which is assumed to reflect extracellular potassium concentration, really improve postoperative outcomes. To assess the usefulness in epilepsy surgery, we collected unique EEG datasets recorded with a longer time constant of 10 sec using an alternate current amplifier. 61 patients [15 with mesial temporal lobe epilepsy and 46 with neocortical epilepsy] who had undergone invasive presurgical evaluation for medically refractory seizures at five institutes in Japan, were retrospectively enrolled in this study. Among intracranially implanted electrodes, the two core electrodes of both icDCs and icHFOs were independently identified by board-certified clinicians based on unified methods. The occurrence patterns, such as their onset time, duration, and amplitude (power) were evaluated to extract the features of both icDCs and icHFOs. Additionally, we examined whether the resection ratio of the core electrodes of icDCs and icHFOs independently correlated with favorable outcomes. A total of 53 patients with 327 seizures were analyzed for wide-band EEG analysis, and 49 patients were analyzed for outcome analysis. icDCs were detected in the seizure-onset zone more frequently than icHFOs among both patients (92% vs. 71%) and seizures (86% vs. 62%). Additionally, icDCs significantly preceded icHFOs in patients exhibiting both biomarkers, and icDCs occurred more frequently in neocortical epilepsy patients than in mesial temporal lobe epilepsy patients. Finally, although a low corresponding rate was observed for icDCs and icHFOs (39%) at the electrode level, complete resection of the core area of icDCs significantly correlated with favorable outcomes, similar to icHFO outcomes. Our results provide a proof of concept that the independent significance of icDCs from icHFOs should be considered as reliable biomarkers to achieve favorable outcomes in epilepsy surgery. Moreover, the different distribution of the core areas of icDCs and icHFOs may provide new insights into the underlying mechanisms of epilepsy, in which not only neurons but also glial cells may be actively involved via extracellular potassium levels