Uncertainty Analysis of Hollow Airfoil Composite Structure by Using Finite Element Method

by using Monte Carlo method. A three dimensional static analysis of large displacement type has been carried out. Finite element analysis of NACA0012 airfoil composite structure has been carried out and uncertainty in Maximum Deflection is analyzed. Maximum Deflection was objective function. Chord length , beam length ,elastic modulus in XY,YZ,XZ and shear modulus of epoxy graphite in  XY,YZ,XZ, ply angle and ply thickness of airfoil section, force are varied within effective range and their effect on Maximum Deflection has been analyzed. In order to validate the results, one loop of simulation is benchmarked from results in literature. Ultimately, best set of probabilistic design variable is proposed to reduce Maximum Deflection under static loadin

Bohring Opitz Syndrome: A case of a rare genetic disorder

Bohring-Opitz syndrome (BOS) is a rare genetic disorder, characterized by feeding difficulties, developmental delay, microcephaly, micrognathia, limb anomalies, and typical phenotypic facial features. The cause of the syndrome is identified as de novo heterogeneous mutations in the ASXL1 gene, but other mutations have been described in some patients. Most patients die in early childhood due to infections and comorbidities. As molecular confirmation by genetic studies is not always possible, this syndrome is diagnosed on the basis of distinctive clinical features. We report a case of the 6-month-old male child having gastroesophageal reflux and physical features of microcephaly, sloping forehead, sparse hair, craniosynostosis, telecanthus, hypertelorism, prominent eyes, posteriorly rotated ears, high-arched palate, micrognathia, pes planus, and typical BOS posture. A multidisciplinary approach is required for managing these patients

Enhanced Quantum Key Distribution Algorithm for Underwater Optical Wireless Sensor Network

The research aims to develop an attack-free underwater optical communication channel at a distance of 50 meters. In this work, we have emphasized the importance of Quantum Key Distribution (QKD) in Naval and many other applications. An in-detail study of the Benette Brassard QKD protocol proposed in 1984 [BB84] is done with its implementation. Then as the next step, we analyzed the drawbacks of BB84 and the necessity of QKD in Underwater Optical Wireless Sensor Networks [UO-WSN]. As a solution, to identified problems, we have proposed the Enhanced BB84 protocol (EBB84) with considerations of its usage in the UO-WSN. The results showed that the EBB84 algorithm is best suitable algorithm for the underwater environment

Policy-aware Distributed and Dynamic Trust based Access Control Scheme for Internet of Things

 The use of smart devices is driving the Internet of Things (IoT) trend today. Day by day IoT helps to support more services like car services, healthcare services, home automation, and security services, weather prediction services, etc, to ease user’s life. Integration of heterogeneous IoT devices and social resources sometimes creates many problems like the privacy of data. To avoid privacy issues, an appropriate access control mechanism is required to check authorized and trusted devices, so that only valid devices can access the data which is only required.  In the sequel, this paper presents implementation of distributed and dynamic trust based access control mechanism (DDTAC) for secure machine to machine communication or distributed IoT environment. Novelty of this mechanism is that, it uses trust calculation and device classification for dynamic access control. The proposed scheme is implemented, tested and deployed on Node MCU and same mechanism is also simulated on NS-2 for large number of nodes. This access control model support Scalability, Heterogeneity, Privacy, Trust, Selective disclosure, Principle of least privileges, and lightweight calculation features. Results of this models proves that it gives good performance as compared to existing scheme in terms of scalability, throughput and delay. As number of devices increase it does not degrade performance. This mechanism is also protected against the Man-in-the-Middle attack, Sniffing attack, Session Hijacking attacks and Injection attacks. It required less time to detect and resist those attacks

Reconstruction Methods for Providing Privacy in Data Mining

Data mining is the process of finding correlations or patterns among the dozens of fields in large database. A fruitful direction for data mining research will be the development of techniques that incorporate privacy concerns. Since primary task in our paper is that accurate data which we retrieve should be somewhat changed while providing to users. For this reason, recently much research effort has been devoted for addressing the problem of providing security in data mining. We consider the concrete case of building a decision tree classifier from data in which the values of individual records have been reconstructed. The resulting data records look very different from the original records and the distribution of data values is also very different from the original distribution. By using these reconstructed distribution we are able to build classifiers whose accuracy is comparable to the accuracy of classifiers built with the original data

Impact of modular mitochondrial epistatic interactions on the evolution of human subpopulations

Investigation of human mitochondrial (mt) genome variation has been shown to provide insights to the human history and natural selection. By analyzing 24,167 human mt-genome samples, collected for five continents, we have developed a co-mutation network model to investigate characteristic human evolutionary patterns. The analysis highlighted richer co-mutating regions of the mt-genome, suggesting the presence of epistasis. Specifically, a large portion of COX genes was found to co-mutate in Asian and American populations, whereas, in African, European, and Oceanic populations, there was greater co-mutation bias in hypervariable regions. Interestingly, this study demonstrated hierarchical modularity as a crucial agent for these co-mutation networks. More profoundly, our ancestry-based co-mutation module analyses showed that mutations cluster preferentially in known mitochondrial haplogroups. Contemporary human mt-genome nucleotides most closely resembled the ancestral state, and very few of them were found to be ancestral-variants. Overall, these results demonstrated that subpopulation-based biases may favor mitochondrial gene specific epistasis

Formulation and evaluation of thermoreversible mucoadhesive nasal gels of metoclopramide hydrochloride

The prolonged residence of drug formulation in the nasal cavity is of utmost importance for intranasal drug delivery. The objective of the present investigation was to develop a mucoadhesive in situ gel with reduced nasal mucocilliary clearance in order to improve the bioavailability of the antiemetic drug, metoclopramide hydrochloride. The in situ gelation upon contact with nasal mucosa was conferred via the use of the thermogelling Pluronic flake 127 (18%). Mucoadhesion was modulated via the use of hydroxy propyl methyl cellulose (HPMC), sodium carboxy methyl cellulose (Na CMC) and sodium alginate (Na-alginate) whereas drug release was modified by varying concentrations of polyethylene glycol 6000 (PEG 6000). The results revealed that the different mucoadhesives increased the gel viscosity but reduced its sol gel transition temperatures. The increase in viscosity was highest in formulations with Na-alginate and lowest in formulations with HPMC. PEG 6000 significantly decreased mucoadhesive strength of formula containing 0.3% HPMC (776.6 ± 19.55 to 713.6 ± 5.03), 0.2% Na CMC (656 ± 11.13 to 575 ± 9.07) and 0.2% Na-alginate (659 ± 11.13 to 618.3 ± 9.45) whereas the gelation temperature increased by 3 to 4 °C. 100% of drug diffusion was found at four hours for formulation F5, F9, and F12. Formulation F5 showed maximum permeability (0.00949 ± 0.00021 mg.cm/min) than other formulation containing PEG6000. This study concluded the potential use of mucoadhesive in situ nasal gel in terms of ease of administration, accuracy of dosing, prolonged nasal residence and improved nasal bioavailability.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Formulation and evaluation of thermoreversible mucoadhesive nasal gels of metoclopramide hydrochloride

The prolonged residence of drug formulation in the nasal cavity is of utmost importance for intranasal drug delivery. The objective of the present investigation was to develop a mucoadhesive in situ gel with reduced nasal mucocilliary clearance in order to improve the bioavailability of the antiemetic drug, metoclopramide hydrochloride. The in situ gelation upon contact with nasal mucosa was conferred via the use of the thermogelling Pluronic flake 127 (18%). Mucoadhesion was modulated via the use of hydroxy propyl methyl cellulose (HPMC), sodium carboxy methyl cellulose (Na CMC) and sodium alginate (Na-alginate) whereas drug release was modified by varying concentrations of polyethylene glycol 6000 (PEG 6000). The results revealed that the different mucoadhesives increased the gel viscosity but reduced its sol gel transition temperatures. The increase in viscosity was highest in formulations with Na-alginate and lowest in formulations with HPMC. PEG 6000 significantly decreased mucoadhesive strength of formula containing 0.3% HPMC (776.6 ± 19.55 to 713.6 ± 5.03), 0.2% Na CMC (656 ± 11.13 to 575 ± 9.07) and 0.2% Na-alginate (659 ± 11.13 to 618.3 ± 9.45) whereas the gelation temperature increased by 3 to 4 °C. 100% of drug diffusion was found at four hours for formulation F5, F9, and F12. Formulation F5 showed maximum permeability (0.00949 ± 0.00021 mg.cm/min) than other formulation containing PEG6000. This study concluded the potential use of mucoadhesive in situ nasal gel in terms of ease of administration, accuracy of dosing, prolonged nasal residence and improved nasal bioavailability.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Role of comprehensive diabetes care in known diabetes patients from western Mumbai region: an observational study

Background: The occurrence of Diabetes Mellitus (DM) has been creating a havoc since past few decades on a global platform. As per available literature, prevalence of DM in Mumbai is around 10%. Comprehensive Diabetes Care (CDC) is a form of Ayurvedic therapy which combines panchkarma and diet management. The present study was planned to evaluate the effectiveness of CDC in patients of DM by analysing changes in body mass index (BMI), body weight, OGTT, HbA1c, etc.Methods: The present study was of retrospective design, conducted at Madhavbaug clinics in western Mumbai. The duration of study was of one year, conducted from October 2018 to September 2019. It included patients diagnosed with type 2 DM i.e. HbA1c>6.5%, who were given CDC therapy.Results: In the present study, out of 183 type 2 diabetic patients, 99 were males (52%), while 84 were females (48%), thus male: female ratio was 1.17:1. On analysing the results of HbA1c in patients who had completed 12 weeks of CDC therapy, it was found that controlled DM status was seen in 109 patients (59%), while uncontrolled DM status was noted in 33 patients (19%) as compared to 102 patients (58%) at baseline.Conclusions: From the findings of the present study, it is clear that CDC is effective in the form of increasing number of euglycemic patients at the end of study period, as well as reduction in all glycaemic and anthropometric parameters, and reducing dependency on conventional medicines

Formulation and evaluation of thermoreversible mucoadhesive nasal gels of metoclopramide hydrochloride

The prolonged residence of drug formulation in the nasal cavity is of utmost importance for intranasal drug delivery. The objective of the present investigation was to develop a mucoadhesive in situ gel with reduced nasal mucocilliary clearance in order to improve the bioavailability of the antiemetic drug, metoclopramide hydrochloride. The in situ gelation upon contact with nasal mucosa was conferred via the use of the thermogelling Pluronic flake 127 (18%). Mucoadhesion was modulated via the use of hydroxy propyl methyl cellulose (HPMC), sodium carboxy methyl cellulose (Na CMC) and sodium alginate (Na-alginate) whereas drug release was modified by varying concentrations of polyethylene glycol 6000 (PEG 6000). The results revealed that the different mucoadhesives increased the gel viscosity but reduced its sol gel transition temperatures. The increase in viscosity was highest in formulations with Na-alginate and lowest in formulations with HPMC. PEG 6000 significantly decreased mucoadhesive strength of formula containing 0.3% HPMC (776.6 ± 19.55 to 713.6 ± 5.03), 0.2% Na CMC (656 ± 11.13 to 575 ± 9.07) and 0.2% Na-alginate (659 ± 11.13 to 618.3 ± 9.45) whereas the gelation temperature increased by 3 to 4 °C. 100% of drug diffusion was found at four hours for formulation F5, F9, and F12. Formulation F5 showed maximum permeability (0.00949 ± 0.00021 mg.cm/min) than other formulation containing PEG6000. This study concluded the potential use of mucoadhesive in situ nasal gel in terms of ease of administration, accuracy of dosing, prolonged nasal residence and improved nasal bioavailability.Colegio de Farmacéuticos de la Provincia de Buenos Aire