Association of Disease Location and Treatment With Survival in Diffuse Large B-Cell Lymphoma of the Eye and Ocular Adnexal Region.

Importance: Primary diffuse large B-cell lymphoma (DLBCL) of the ocular region is rare, and the utility of surgery and radiation therapy remains unresolved. Objective: To explore the clinical characteristics and determine factors associated with overall survival in primary vitreoretinal lymphoma (PVRL) and ocular adnexal (OA)-uveal DLBCL. Design, Setting, and Participants: This retrospective analysis included 396 patients with ophthalmic DLBCL from January 1, 1973, through December 31, 2014, using the Surveillance, Epidemiology, and End Results database. The median follow-up was 39.0 months (interquartile range, 5.1-72.9 months). All patients diagnosed with primary DLBCL of the eye or retina (PVRL) or the eyelid, conjunctiva, choroid, ciliary body, lacrimal gland, or orbit (OA-uveal lymphoma) were included. Patients diagnosed at autopsy or with additional neoplastic disease were excluded. Main Outcomes and Measures: Patient demographic characteristics, disease location, treatment modalities, and overall survival. Results: Forty-seven patients with PVRL (24 women [51.1%] and 23 men [48.9%]) and 349 with OA-uveal DLBCL (192 women [55.0%] and 157 men [45.0%]) had a similar mean (SD) age at diagnosis (69.6 [12.3] vs 66.1 [17.7] years). No difference in the use of surgery or radiation therapy by location was found. For all PVRL and OA-uveal DLBCL, a Cox proportional hazards regression model affirmed that age older than 60 years was associated with increased risk for death (hazard ratio [HR], 2.7; 95% CI, 1.9-4.0; P \u3c .001). Gross total resection was associated with a decreased risk for death (HR, 0.5; 95% CI, 0.3-0.9; P = .04), whereas radiation therapy was not. The 5-year overall survival among patients with PVRL was 41.4% (SE, 8.6%); among those with OA-uveal DLBCL, 59.1% (SE, 2.8%; Mantel-Cox test, P = .007). Median overall survival was lower in PVRL (38.0 months; 95% CI, 14.2-61.8 months) than in OA-uveal DLBCL (96.0 months; 95% CI, 67.3-124.7 months; Mantel-Cox test, P = .007). In addition, median overall survival in ophthalmic-only disease was higher (84.0 months; 95% CI, 63.2-104.8 months) than that in primary DLBCL that occurred outside the central nervous system and ophthalmic regions (46.0 months; 95% CI, 44.4-47.6 months; Mantel-Cox test, P \u3c .001). Conclusions and Relevance: The 5-year survival in PVRL vs OA-uveal DLBCL differed by 17.7%, and overall survival was greater in ophthalmic DLBCL than in DLBCL located outside the central nervous system and ophthalmic regions. Younger age (≤60 years) and gross total resection were associated with increased survival

A ruggedized thin-window proportional-counter tube

Design and testing of ruggedized, thin window proportional counter tube for detecting X rays in light element

The Monterey event in the Mediterranean: A record from shelf sediments of Malta

Oligo-Miocene carbonate platform and shelf sediments outcropping on the Maltese Islands provide an excellent archive of the paleoceanography of the central Mediterranean. A sequence of shallow water limestones, than shelf limestones, and marls, followed again by shallow water limestones, reflects drowning of a carbonate platform, the establishment of a shelf environment and, in the late Miocene, renewed progradation and aggradation of shallow water carbonates. The sequence recording the deepening of the Maltese platform contains several phosphorite hardgrounds and phosphorite pebble beds. These phosphorites were dated with strontium isotopes. Major episodes of phosphogenesis occurred between 25 and 16 Ma, and they are coeval with those phosphorite events reported from Florida and North Carolina. A Miocene carbon isotope and oxygen isotope stratigraphy was established on planktic and benthic foraminifera and on bulk samples. A major carbon isotope excursion with an amplitude of up to +l‰ between 18 and 12.5 Ma can be correlated with the globally recognized Monterey carbon isotope excursion. This is the first record of this event both in shallow water sediments and in the Mediterranean. The carbon isotope excursion precedes an oxygen isotope excursion which also was recognized in deep-sea records. Major episodes of phosphogenesis and platform drowning preceded the carbon isotope excursion by up to millions of years

LIVINGSTON COUNTY EMERGENCY SERVICES ANALYSIS

Rapid population growth challenges the ability of local government to keep pace with increasing and changing demand for public services. These challenges may be physical or organizational in nature. Physical challenges arise from the need to upgrade public infrastructure such as water and sewer service, roads, schools, and emergency services. Although installation of new infrastructure is always expensive, growth-related increases in the tax base provide new revenue for installation of new services. However, when slowing growth rates, againg infrastructure, and addition of expensive new services pressure local government to increase revenue from existing resources decision-makers may then seek to reduce per-capita costs by reorganizing the method or structure of providing community services.Public Economics,

The Lyman Continuum Polarization Rise in the QSO PG 1222+228

Some QSOs show an abrupt, strong rise in polarization near rest wavelength 750 A. If this arises in the atmosphere of an accretion disk around a supermassive black hole, it may have diagnostic value. In PG 1222+228, the polarization rise occurs at the wavelength of a sharp drop in flux. We examine and reject interpretations of this feature involving a high velocity outflow. The observations agree with a model involving several intervening Lyman limit systems, two of which happen to coincide with the Lyman continuum polarization rise. After correction for the Lyman limit absorption, the continuum shortward of 912 A is consistent with a typical power-law slope, alpha = -1.8. This violates the apparent pattern for the Lyman limit polarization rises to occur only in ``candidate Lyman edge QSOs''. The corrected, polarized flux rises strongly at the wavelength of the polarization rise, resembling the case of PG 1630+377. The rise in polarized flux places especially stringent requirements on models.Comment: 19 pages, including 5 EPS figures. Uses aaspp4.sty. Accepted for publication in Publications of the Astronomical Society of the Pacific, 2000 Ma

Cartoon: Governor Langer Saves the Family Farm, 1936

W.H. Shields drew this cartoon in 1936, when William Langer was elected Governor for a second time. As a man and his wife look out over their farmstead, the man says, Well Mother - we won\u27t lose out home now --- Bill Langer is Governor Again. At the couple\u27s feet is an issue of the Nonpartisan League newspaper, The Leader. The headline reads Langer Declares Moratorium. A cat also is at the man\u27s feet.https://commons.und.edu/langer-papers/1052/thumbnail.jp

Alien Registration- Shields, H D. (Island Falls, Aroostook County)

https://digitalmaine.com/alien_docs/34951/thumbnail.jp

MAXIMUM PRICES WITH RESPECT TO AGRICULTURAL COMMODITIES

As we all know, prices of agricultural commodities during this war have been directly and substantially affected by Government controls and will probably continue to be so affected in the immediate future. These controls take two forms: First, there are those relating to price floors, that is, minimum support prices with respect to agricultural commodities; and, second, there are those relating to price ceilings, that is, maximum prices with respect to agricultural commodities

Power Generation by Harvesting Ambient Energy with a Micro-Electromagnetic Generator

This thesis investigated the potential power output of a micro-electromagnetic generator fabricated using typical microfabrication materials and techniques. The design was based on a desire to free bio-implanted or remote electronic devices from batteries and their finite power supplies. A micro-electromagnetic generator could harvest energy from the ambient environment and power such devices indefinitely. Designs for the stator coil and rotor magnet components of the generator were optimized to produce maximum current density based upon electromagnetic theory. The relative orientation of the coil to the rotor and material selection for each component were considered. Coils were fabricated using low-resistance gold. A method for overlaying two evaporated gold wires was devised and successfully fabricated in order to avoid side-wall thinning of the coils which has been shown to lead to high resistivities. Rotors were made with nickel, a ferromagnetic material. The required parameters for reduced stress plating using a nickel electroplating bath were investigated in order to pattern and deposit nickel for the rotors. Once fabricated, the rotors were magnetized through the use of an electromagnet. In addition, a testing apparatus that provided precise alignment, a method of rotation to simulate operational functionality, and power measurement capabilities was designed and assembled. Testing of the magnets showed that the nickel rotors were able to be highly magnetized when placed near a strong field. However, upon removal from the field the magnetization quickly dissipated. It was determined that the coercivity, or magnetic hardness, of electroplated nickel was too low for the rotor magnets to retain a field for any appreciable amount of time. Testing of the micro-generator revealed that power output did not exceed 2 nA, which was expected given that the magnetic rotors did not retain their flux density. It was shown that nickel does not maintain the flux density required for a micro-electromagnetic generator and different materials should be investigated