Review of The Shadow of the Precursor edited by Diana Glenn, Md Rezaul Haque, Ben Kooyman and Nena Bierbaum

Review of The Shadow of the Precursor edited by Diana Glenn, Md Rezaul Haque, Ben Kooyman and Nena Bierbau

Shirley Hazzard: New Critical Essays, edited by Brigitta Olubas

Review of Shirley Hazzard: New Critical Essays, edited by Brigitta Oluba

Lost Generation: Women Writers in Postwar Australia. [abstract].

Australia, 1959: In Tasmania, poet Gwen Harwood starts sending out her poems under male pseudonyms, after several encounters with misogynist literary editors; Dorothy Hewett, silent for the previous decade, publishes "Bobbin Up", a successful novel in the social realist mode approved by the Communist Party (of which she was a member) but one that allowed little scope to her poetic gifts or her theatrical ambitions; Elizabeth Jolley arrives in Perth from England and begins to send out stories, but must wait until 1976 to publish a book. They are but three of the generation of women writers who were largely lost from view in the 1950s and 60s, and who are now in danger of being eclipsed in subsequent histories. In looking for answers to the question of why their early careers were so beset with difficulties, Professor Sheridan hopes at the same time to create a picture of the literary culture of the period that will be different because of the presence of women in it – and to offer accounts of these women’s writing lives that will expand our understanding of their art and its continuing significance

Review of 'My Blood's Country' by Fiona Capp

Review of 'My Blood's Country' by Fiona Cap

Gentlemen's agreements: Southerly's first editors

This article describes the early years of the journal 'Southerly'. Academic R.G. (Guy) Howarth and poet Kenneth Slessor were the first two editors. This article is focused on the friendship of the first two editors, their shared literary tastes, and their relations with other literary figures. Slessor and Howarth shared a moderate taste for literary modernism and a strong taste for literary socialising. Their story, seen as part of a larger story about writing and gender on the post-war Australian literary scene, offers a telling illustration of the way a literary magazine operated its predominantly male networks

Christina's Stead's Last Book: The Novel and the Best-Seller

NS

ZMYND10 Is Mutated in Primary Ciliary Dyskinesia and Interacts with LRRC6

Defects of motile cilia cause primary ciliary dyskinesia (PCD), characterized by recurrent respiratory infections and male infertility. Using whole-exome resequencing and high-throughput mutation analysis, we identified recessive biallelic mutations in ZMYND10 in 14 families and mutations in the recently identified LRRC6 in 13 families. We show that ZMYND10 and LRRC6 interact and that certain ZMYND10 and LRRC6 mutations abrogate the interaction between the LRRC6 CS domain and the ZMYND10 C-terminal domain. Additionally, ZMYND10 and LRRC6 colocalize with the centriole markers SAS6 and PCM1. Mutations in ZMYND10 result in the absence of the axonemal protein components DNAH5 and DNALI1 from respiratory cilia. Animal models support the association between ZMYND10 and human PCD, given that zmynd10 knockdown in zebrafish caused ciliary paralysis leading to cystic kidneys and otolith defects and that knockdown in Xenopus interfered with ciliogenesis. Our findings suggest that a cytoplasmic protein complex containing ZMYND10 and LRRC6 is necessary for motile ciliary function

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts