The many faces of nodal policing: Team play and improvisation in Dutch community safety

In this paper we reflect on how one police organization, the Dutch police, have acted to embrace nodal assemblages and nodal governance while they have pioneered a form of ‘conduit policing’ (Shearing, 1999). This strategy, conceived as policing with a ‘nodal orientation’, combines policing attention on flows of people, information and things through infrastructural nodes with the policing of local communities (Project Group Vision on Policing, 2006). We examine four initiatives of the Dutch police that illustrate different aspects of policing assemblages in Amsterdam. The analysis considers how these nodes have worked to integrate different, but compatible, conceptions of nodal policing

The Rio Grande Rise and Jean Charcot Seamount Chain - microcontinents or the trail of the Tristan-Gough hotspot? Cruise No. MSM 82, 18 March 2019 - 24 April 2019, Montevideo (Uruguay) - Montevideo (Uruguay), RIOGRANDE

Rio Grande Rise: microcontinent, mantle plume, or both? The origin of the Rio Grande Rise (RGR) is debated. It could represent a continental sliver, or a large igneous province that was emplaced in the late Cretaceous after the opening of the South Atlantic Ocean. The interplay between the RGR and the nearby Jean Charcot Seamount Chain (JCSC) is also not understood. Cruise MSM82 dredge sampled rocks from the JCSC and the RGR and measured two seismic refraction profiles across the RGR where it is bisected by a long rift graben. A range of geophysical data were also collected during much of the expedition, including magnetics, gravity, bathymetry (Kongsberg EM 122), sub-bottom profiling (ATLAS PARASOUND DS P70) and ADCP data. The combination of geochronological, geochemical and geophysical information will provide a unique window on the relation between mantle plumes, continental fragments and the evolution of large igneous provinces

X-ray micro-computed tomography of polymer electrolyte fuel cells: what is the representative elementary area?

With the growing use of X-ray computed tomography (X-ray CT) datasets for modelling of transport properties, comes the need to define the representative elementary volume (REV) if considering three dimensions or the representative elementary area (REA) if considering two dimensions. The resolution used for imaging must be suited to the features of interest in the sample and the region-of-interest must be sufficiently large to capture key information. Polymer electrolyte fuel cells have a hierarchical structure, with materials spanning multiple length scales. The work presented here examines the nature of the REA throughout a 25 cm2 membrane electrode assembly (MEA), focusing specifically on the micron length scale. Studies were carried out to investigate key structural (volume fraction, layer and penetration thickness, pore diameters) and transport (effective diffusivity) properties. Furthermore, the limiting current density of the nine regions was modelled. Stochastic heterogeneity throughout the sample results in local variations throughout. Finally, effects of resolution were probed by imaging using a range of optical magnifications (4× and 20×). The correlated and competing effects of voxel resolution and sampling size were found to cause difficulties where loss of clarity in the boundaries between phases occurs with larger imaging volumes.Jennifer Hack acknowledges a studentship from the EPSRC Centre for Doctoral Training in Advanced Characterisation of Materials (EP/LO15277/1) and the hydrogen and fuel cell research in the Electrochemical Innovation Lab (EIL) is supported through EPSRC projects (EP/M014371/1, EP/S018204/2, EP/R023581/1, EP/P009050/1, EP/L015749/1, EP/M009394/1, EP/M023508/1). Paul R. Shearing acknowledges funding from the Royal Academy of Engineering (CiET1718/59). Pablo A. García-Salaberri thanks the support from the STFC Early Career Award (ST/R006873/1) during his stay at the EIL

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia.

The occurrence of non-epileptic hyperkinetic movements in the context of developmental epileptic encephalopathies is an increasingly recognized phenomenon. Identification of causative mutations provides an important insight into common pathogenic mechanisms that cause both seizures and abnormal motor control. We report bi-allelic loss-of-function CACNA1B variants in six children from three unrelated families whose affected members present with a complex and progressive neurological syndrome. All affected individuals presented with epileptic encephalopathy, severe neurodevelopmental delay (often with regression), and a hyperkinetic movement disorder. Additional neurological features included postnatal microcephaly and hypotonia. Five children died in childhood or adolescence (mean age of death: 9 years), mainly as a result of secondary respiratory complications. CACNA1B encodes the pore-forming subunit of the pre-synaptic neuronal voltage-gated calcium channel Cav2.2/N-type, crucial for SNARE-mediated neurotransmission, particularly in the early postnatal period. Bi-allelic loss-of-function variants in CACNA1B are predicted to cause disruption of Ca2+ influx, leading to impaired synaptic neurotransmission. The resultant effect on neuronal function is likely to be important in the development of involuntary movements and epilepsy. Overall, our findings provide further evidence for the key role of Cav2.2 in normal human neurodevelopment.MAK is funded by an NIHR Research Professorship and receives funding from the Wellcome Trust, Great Ormond Street Children's Hospital Charity, and Rosetrees Trust. E.M. received funding from the Rosetrees Trust (CD-A53) and Great Ormond Street Hospital Children's Charity. K.G. received funding from Temple Street Foundation. A.M. is funded by Great Ormond Street Hospital, the National Institute for Health Research (NIHR), and Biomedical Research Centre. F.L.R. and D.G. are funded by Cambridge Biomedical Research Centre. K.C. and A.S.J. are funded by NIHR Bioresource for Rare Diseases. The DDD Study presents independent research commissioned by the Health Innovation Challenge Fund (grant number HICF-1009-003), a parallel funding partnership between the Wellcome Trust and the Department of Health, and the Wellcome Trust Sanger Institute (grant number WT098051). We acknowledge support from the UK Department of Health via the NIHR comprehensive Biomedical Research Centre award to Guy's and St. Thomas' National Health Service (NHS) Foundation Trust in partnership with King's College London. This research was also supported by the NIHR Great Ormond Street Hospital Biomedical Research Centre. J.H.C. is in receipt of an NIHR Senior Investigator Award. The research team acknowledges the support of the NIHR through the Comprehensive Clinical Research Network. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, Department of Health, or Wellcome Trust. E.R.M. acknowledges support from NIHR Cambridge Biomedical Research Centre, an NIHR Senior Investigator Award, and the University of Cambridge has received salary support in respect of E.R.M. from the NHS in the East of England through the Clinical Academic Reserve. I.E.S. is supported by the National Health and Medical Research Council of Australia (Program Grant and Practitioner Fellowship)

Nodal Governance, Democracy, and the New 'Denizens'

We begin this paper by reviewing some recent transformations in governance. We then propose three new concepts that we believe assist us in coming to terms with these transformations and the political statuses that have emerged as part of them. These concepts are 'nodal governance', 'denizens', and 'communal space'. Following this we will explore the normative implications of nodal governance as it has taken shape to date, with an emphasis on the 'governance disparity' that is paralleling the 'wealth disparity' across the globe. In response to this disparity, we will end with an outline of a normative vision and practical programme aimed at deepening democracy in poor areas of South Africa, Argentina, and elsewhere. We will argue that the main virtue of nodal governance, namely, the emphasis on local capacity and knowledge can be retrieved, reaffirmed, and reinstitutionalized in ways that enhance the self-direction of poor communities while strengthening their 'collective capital'