1,322 research outputs found

    The Double Club evaluation : interim report

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    A Death in the Cottage : Spiritual and Economic Improvement in Romantic-Era Scottish Death Narratives

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    Peer reviewedPostprin

    A club of “murder-fanciers” : Thomas De Quincey’s essays “On Murder” and consuming violence in Blackwood’s Edinburgh Magazine

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    Open Access via the Taylor and Francis/JISC agreement Funding by Wolfson FoundationPeer reviewedPublisher PD

    The in vivo characterisation of a C-domain specific ACE inhibitor

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    Includes bibliographical references.The ACE protein is a zinc-dependent dipeptidyl carboxypeptidase comprised of two homologous domains termed the C- and N-domain. The C-domain is primarily responsible for the catalytic production of Ang II, while the tetrapeptide acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is predominantly cleaved by the N-domain, and both domains play a role in the metabolism of vasodilatory peptide bradykinin. In the event of myocardial infarction (MI), cardiac output and blood pressure decreases, resulting in activation of the RAS and an increase in both Ang II production and bradykinin metabolism. While initially compensatory, prolonged RAS activation has been shown to have long-term detrimental effects, and pharmaceutical intervention in the form of ACE inhibition is the first line treatment following an MI event. The ACE inhibitors currently in clinical use target both domains equally, and it has been suggested that the major side-effects of this drug class are largely attributable to the inhibition of bradykinin breakdown. A novel C-domain selective ACE inhibitor lisinopril-Trp (lisW-S) incorporates a tryptophan moiety into the P2' position of the clinically available ACE inhibitor lisinopril

    The Federal Child Nutrition Commodity Program: A Report on Nutritional Quality

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    Examines the types of food California schools order through the USDA Child Nutrition Commodity Program and how they affect the nutritional value of school meals. Includes policy recommendations for ensuring that meals meet nutritional guidelines

    The Double Club evaluation

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