Synthesis of α-amino phosphonates by diastereoselective addition of diethyl phosphite sodium salt to aldimines derived from Betti base

© 2016A diastereoselective (de 80–92%) synthesis of α-amino phosphonates was accomplished by reaction of diethyl phosphite sodium salt with 3-R-1-phenyl-2,3-dihydro-1H-naphth[1,2-e]-[1,3]oxazines being the products of aminoacetalization of aldehydes with 1-(α-aminobenzyl)-2-naphthol (Betti base)

Leadership in the university student environment: How to become a person-oriented leader

© 2018 International Journal of Instruction. Currently there is a vital need to teach youth to demonstrate leadership skills as well as to work in the competitive market environment. This article is devoted to the problem of leadership training among university students. The sample included 474 students of Kazan Federal University. The project was based on the use of person-oriented interaction between the university tutors and students to help young people overcome the barriers to develop leadership qualities while being engaged in the organizational activities. In the first phase, the participants' levels of leadership qualities, organizational inclination, and communication skills were determined. The experimental stage was aimed at teaching student organizers create a positive atmosphere in the group being guided by the principles of person-oriented interaction between a leader and his followers. The experiment has demonstrated that collaboration of people with a high level of leadership qualities and those ones with a low level of leadership qualities do not give positive results. Collaboration with the university tutors gave support to the student participants and helped them develop the traits of a leader

Phosphorylation of betti base with diethyl chlorophosphate

© 2016, Pleiades Publishing, Ltd.Phosphoric acid derivatives containing chiral Betti base fragment were synthesized by reacting racemic and enantiopure N-Boc-protected 1-(α-aminobenzyl)-2-naphthols with diethyl chlorophosphate followed by deprotection

New approaches to Tay-Sachs disease therapy

Copyright © 2018 Solovyeva, Shaimardanova, Chulpanova, Kitaeva, Chakrabarti and Rizvanov. Tay-Sachs disease belongs to the group of autosomal-recessive lysosomal storage metabolic disorders. This disease is caused by β-hexosaminidase A (HexA) enzyme deficiency due to various mutations in α-subunit gene of this enzyme, resulting in GM2 ganglioside accumulation predominantly in lysosomes of nerve cells. Tay-Sachs disease is characterized by acute neurodegeneration preceded by activated microglia expansion, macrophage and astrocyte activation along with inflammatory mediator production. In most cases, the disease manifests itself during infancy, the “infantile form,” which characterizes the most severe disorders of the nervous system. The juvenile form, the symptoms of which appear in adolescence, and the most rare form with late onset of symptoms in adulthood are also described. The typical features of Tay-Sachs disease are muscle weakness, ataxia, speech, and mental disorders. Clinical symptom severity depends on residual HexA enzymatic activity associated with some mutations. Currently, Tay-Sachs disease treatment is based on symptom relief and, in case of the late-onset form, on the delay of progression. There are also clinical reports of substrate reduction therapy using miglustat and bone marrow or hematopoietic stem cell transplantation. At the development stage there are methods of Tay-Sachs disease gene therapy using adeno- or adeno-associated viruses as vectors for the delivery of cDNA encoding α and β HexA subunit genes. Effectiveness of this approach is evaluated in α or β HexA subunit defective model mice or Jacob sheep, in which Tay-Sachs disease arises spontaneously and is characterized by the same pathological features as in humans. This review discusses the possibilities of new therapeutic strategies in Tay-Sachs disease therapy aimed at preventing neurodegeneration and neuroinflammation

Chiral thiophosphorylated thioureas: Synthesis, structure, and cyclization reaction

© 2014 Wiley Periodicals, Inc. A number of chiral racemic and enanthiopure thiophosphorylated thioureas were synthesized by the reaction of 2-aminobutan-1-ol and 1-(a-aminobenzyl)-2-naphthol with O,O-diethyl thiophosphoryl isothiocyanate. It was found that such thioureas undergo the cyclization reaction under basic conditions with hydrogen sulfide elimination and the formation of thiophosphorylated oxasines. XRay single crystal diffraction revealed that the structure of thiourea is close to the prereaction state of the cyclization reaction

EFFECT OF LASER MOTION DIRECTION ON THE MAGNETIC PROPERTIES OF SAMPLES PRODUCED BY SLS METHOD

The study of the magnetic properties of iron powder samples after SLS production was carried out. It was shown that the direction of laser motion affects the magnetic parameters of the samples.Работа выполнена при частичной финансовой поддержке гранта РНФ № 21-72-10104

ЛИЧНОСТНЫЕ ОТНОШЕНИЯ В ФУТБОЛЬНОЙ КОМАНДЕ

This report examines that are important in the formation of interpersonal relationships and psychological climate in the team, which develops between the athletes in the course of their activities and communication.В статье рассматриваются межличностные отношения, играющие немаловажную роль в формировании психологического климата в команде, который складывается между спортсменами в процессе их деятельности и общения

Socialization of foreign university students through the formation of reading literacy

© 2020, Association for Social Studies Educa. All rights reserved. The article considers the concept of reading literacy as a means of successful socialization of foreign students of Elabuga Institute of Kazan Federal University. As a prerequisite for the research served the growth of number of foreign students in the Institute. That in its chain caused the problem of socialization of foreign students in the Russian society. The authors analyze the process of reading literacy formation at three levels (baseline, functional, multiple). Each level corresponds to a certain stage of learning a foreign language (the language of the host country). The first stage presumes a digital educational resource “Russian as a foreign language (RuStart)”. At the second stage students’ study at preparatory courses of studying Russian as a foreign language on the basis of university. The third stage of socialization of foreign students (multiple literacy) is characterized by formation of students' professional socialization by means of studying the English language. The level of socialization of students at each of the considered stages is determined. Besides, the influence of reading literacy on the process of socialization of foreign students is revealed. The aim of the paper is to reveal and analyse value of reading literacy in the course of socialization of students from Central Asia in the Republic of Tatarstan (Russia). To meet the aims of the research the authors use cross sectional research design. To reveal a relationship between reading literacy levels and students' socialization, the authors track changes at every stage of the study through testing, questioning, and interviewing foreign students. Thus, correlation characteristics are determined. The impact of the development of reading literacy on the socialization of foreign students becomes evident through the analysis of the results of interviews. The analysis is performed using the method of correlational analysis. The conducted research revealed the integral role of reading literacy in socialization of foreign students in our higher education institution

L'Espoir du Morbihan : organe régional du Parti communiste français

10 mars 19461946/03/10 (N95).Appartient à l’ensemble documentaire : Bretagn

Pharmacoepidemiology of antiepileptic drugs in children: Comparative analysis of efficacy and safety

Pharmacoepidemiology analysis of efficacy and safety of antiepileptics was carried out in children (3 months-18 years old) registered with municipal children's epilepsy services: 548 children in 2005, 718 - In 2007 and 32 - In 2011. We used remission lasting for 1 year or longer, and 3 years or longer as primary effectiveness outcomes, and total number of people with adverse effects as a safety outcome. We found no advantages of newer antiepileptics over the older ones in terms of either efficacy or safety. Long-term follow up (more than 3 years) showed higher treatment response rate in patients with childhood versus juvenile absence epilepsy. © 2012 - IOS Press and the authors. All rights reserved