Bay Leaf (Syzygium Polyanthum) Extract Effect on IL-10 and IL-6 Gene Expression in Traumatic Ulcer

The aims of this research is to prove the effect of bay leaf extract gel on IL-10 and IL-6 gene expression in traumatic ulcers. The research method using In vivo experimental study with a randomized posttest-only control group design. The total sample was 24 male Wistar rats, divided into four groups. Group K1 (given base gel), group K2 (given Kenalog in Orabase), group K3 (10% bay leaf extract gel), and group K4 (15% bay leaf extract gel) were given treatment for 5 days. IL-6 and IL-10 levels were tested using the One-Way Anova test, followed by the Tamhane Post Hoc test. This study revealed that there was a difference in IL-6 levels in the K4 group compared to the K1 group sig. (p = 0.007) and a significant difference in IL-10 levels in the K4 group compared to the K1 group. (p = 0.003) after being given topical treatment with bay leaf extract gel. The conclusion of this research is treatment with 15% bay leaf gel extract (Syzygium polyanthum) was proven to significantly increase IL-10 gene expression and decrease IL-6 gene expression in Wistar rats model of traumatic ulcers

BAY LEAF (SYZYGIUM POLYANTHUM) EXTRACT EFFECT ON IL-10 EXPRESSION IN ORAL ULCER

Background: Traumatic ulcers were pathological conditions characterized by loss of epithelial and basal layers resulting from tissue surface excavation caused by trauma. Ulcer healing process consisted of inflammatory, proliferation, and maturation phases. One of the cytokines that play a role in the anti-inflammatory process was IL-10 which worked by balancing the excessive amount of pro-inflammatory cytokines. Bay leaf contained flavonoids which had anti-inflammatory effects. This study’s objective is to determine the effect of bay leaf extract gel on IL-10 expression in the healing process of traumatic ulcers.Method: This study was an analytical study of true experimental laboratories post-test only, consisting of four groups and a sample of 20 male Wistar rats. Mucous ulcers on rat lip were treated with bay leaf extract gel until the 3rd and 5th days. Rat mucosal tissue would be made histological preparations with immunohistochemical staining and calculated IL-10 expression using the Hotspot method. Data obtained then analyzed using Independent T-Test.Result: Results explained that there was a significant increase in IL-10 expression in the group treated using 10% bay leaf extract gel than the control group on 3rd and 5th day, which was marked by a significant p <0.05.Conclusion: The conclusion obtained was 10% bay leaf extract (Syzygium polyanthum) Gel effective in increasing IL-10 expression in the healing of the mucous traumatic ulcer of the mouth of the Wistar rat

Description Of Primary School Student Behavior Post The 21 Days Tooth Brushing Program (Survey Of Students At Sdn Bangetayu Wetan 01 Semarang City)

Background: The high incidence of dental caries in elementary school-aged children was a public health problem. One effort to reduce the high rate of dental caries was through a 21-day tooth brushing program. It was hoped that the behavior would form permanently and become a habit. The purpose is to find out the description of elementary school students' behavior after the 21-day tooth brushing program.Method: The type of research was descriptive observational. The population in this study was elementary school students at SDN Bangetayu Wetan 01 Semarang City, totaling 386 students from grades 1 to 6. The sampling technique used was a total sampling technique which was in accordance with research inclusion and exclusion criteria, resulting in 105 samples. Data were subjected to descriptive statistical analysis.Result:The study showed that changes in dental and oral health maintenance behavior after the 21-day tooth brushing intervention were mostly in the sufficient category (49.5%). The majority of students' 21-day tooth brushing practice was in the routine category (82.9%). Conclusion: The most common characteristics of respondents were female (62.9%) and 10 years old (24.8%).Through the 21-day tooth brushing program, the students of SDN Bangetayu Wetan 01 Semarang City formed dental and oral health maintenance behavior