Multifocal tuberculosis presenting with osteoarticular and breast involvement

BACKGROUND: Polyarticular involvement, wrist and ankle arthritis are uncommon presentation of skeletal tuberculosis. Tuberculosis of the breast is also extremely rare. CASE PRESENTATION: Wrist, ankle and breast involvement were detected in the same patient. Mycobacterium tuberculosis was isolated from both synovial and breast biopsy specimen cultures. CONCLUSIONS: In general, tuberculosis arthritis is a frequently missed diagnosis, especially in different clinical patterns. A high level of suspicion is required particularly in high-risk populations and endemic areas

A granuloma annulare case without annular lesion: A rare variant

Granuloma annulare (GA) is a benign, inflammatory and granulomatous disease which can be seen in both children and adults, with no known etiology. In this report, a 69-year-old female patient who was admitted with multiple non-annular papular lesions on the extensor sides of both arms was presented. [Med-Science 2018; 7(2.000): 416-7

Screening of non-syndromic early-onset child and adolescent obese patients in terms of LEP, LEPR, MC4R and POMC gene variants by next-generation sequencing

Objectives Non-syndromic monogenic obesity is a rare cause of early-onset severe obesity in the childhood period. The aim of this study was to screen four obesity related genes (LEP, LEPR, MC4R and POMC) in children and adolescents who had severe, non-syndromic early onset obesity. Methods Next-generation sequencing of all exons in LEP, LEPR, MC4R and POMC was performed in 154 children and adolescents with early onset severe obesity obesity. Results Fifteen different variants in nineteen patients were identified with a variant detection rate of 12.3%. While six different heterozygous variants were observed in MC4R gene (10/154 patients; 6.5%), five different variants in POMC gene (four of them were heterozygous and one of them was homozygous) (6/154 patients; 3.9%) and four different homozygous variants in LEPR gene (3/154 patients; 1.9%) were described. However, no variants were detected in the LEP gene. The most common pathogenic variant was c.496G>A in MC4R gene, which was detected in four unrelated patients. Six novel variants (6/15 variants; 40%) were described in seven patients. Four of them including c.233C>A and c.752T>C in MC4R gene and c.761dup and c.1221dup in LEPR gene were evaluated as pathogenic or likely pathogenic. Conclusions In conclusion, MC4R variants are the most common genetic cause of monogenic early-onset obesity, consistent with the literature. The c.496G>A variant in MC4R gene is highly prevalent in early-onset obese patients

Parents' awareness of their children's oral-dental health: Knowledge, attitudes and practices

This study aimed to determine parental knowledge and behavior about oral health and dental care. For this purpose, we also examined the relationship between demographic characteristics and the oral-dental health behavior of parents. This study consisted of 269 parents who visited the pediatric outpatient clinic of the hospital between December 2017-January 2019. Data were collected using the researchers' prepared oral health and dental care assessment form. To determine the parents' level of knowledge and behavior regarding oral and dental health, a total of 45 questionnaires were administered with face-to-face interview technique, including demographic characteristics (4 questions), knowledge (19 questions), oral-dental behavior (18 questions), and personal opinion (4 questions). 269 parents (231 females and 38 males) participated in the study. The average age of the parents was 30.6±6.9 years (range: 18-62 years). 118 parents (43.9%) graduated from middle-high school, 109 parents (40.5%) were primary school graduates, 33 parents (12.3%) were university graduates, and five parents were illiterate people (1.9%). The parents did not have enough information about nutrition, fluoride therapy, and dental flossing. There was no statistically significant difference between education level and the number of correct answers (p=0.133). As a result, providing accurate and appropriate knowledge to children by their parents will affect oral-dental health positively. Whether it is a child or adolescent, regular periodic education programs for the protection and development of oral and dental health, as well as the contribution of the school and the family, are essential. [Med-Science 2022; 11(4.000): 1599-602

Mechanical properties of lime-treated clay reinforced with different types of randomly distributed fibers

WOS: 000429070100016In this paper, a comparative experimental study was carried out to evaluate the effect of inclusion of different fiber types on strength of lime-stabilized clay. In this scope, a series of unconfined compressive strength tests were carried out on specimens including basalt and polypropylene fiber compacted under Standard Proctor effort (i.e., 35% by weight of soil). The effects of curing period (1, 7, 28, and 90 days), fiber type (basalt and polypropylene), fiber content (0, 0.25, 0.5, 0.75, 1%), fiber length (6, 12, and 19 mm), and lime content (0 and 9%) on strength properties were investigated. The results revealed that both basalt and polypropylene fibers increased the strength without inclusion of lime. For specimens including lime, strength of polypropylene fiber-reinforced specimens was remarkably higher than that reinforced with basalt fiber for lime-stabilized clay. However, greatest strength improvement was obtained by use of 0.75% basalt fiber of 19 mm length with 9% lime content after 90-day curing. Additionally, results of strength tests on specimens including 3 and 6% lime and 12-mm basalt fiber after 1, 7, 28, and 90-day curing were presented. It is evident that the use of 6-mm basalt fiber and 12-mm polypropylene fiber were the best options; however, efficiency of fiber inclusion is subject to change by varying lime contents. It was also observed that the secant modulus was increased by use of lime; however, strength of the correlations among secant modulus and unconfined compressive strength values was decreased by increasing amount of lime for specimens including both basalt and polypropylene fibers

Interleukin-1Ra rs2234663 and Interleukin-4 rs79071878 Polymorphisms in Familial Mediterranean Fever

WOS: 000372761300010PubMed ID: 26861613Objective: Familial Mediterranean Fever (FMF) is an autosomal recessively inherited auto inflammatory disorder. MEFV gene, causing FMF, encodes pyrin that is associated with the interleukin-1 (IL-1) related inflammation cascade. The aim of this study was to investigate the relationship of interleukin-1 receptor antagonist (IL-1Ra) and interleukin-4 (IL-4) polymorphisms with the risk of FMF in the Turkish population. Methods: This study included 160 patients with FMF (74 men, 86 women) and 120 healthy controls (50 men, 70 women), respectively. Genotyping of IL-1Ra rs2234663 polymorphism was evaluated by gel electrophoresis after polymerase chain reaction (PCR). The IL-4 rs79071878 polymorphism was determined by PCR-based restriction fragment length polymorphism (PCR-RFLP) analysis. The results of analyses were evaluated for statistical significance. Results: There was no significant difference in IL-1Ra genotype and allele distributions between FMF and the control groups (p > 0.05). However, a significant association was observed between FMF patients and control groups according to IL-4 genotype distribution (p = 0.016), but no association was found in the allelic frequency of IL-4 between FMF patients and the controls (p > 0.05, OR: 1.131, Cl 95%: 0.71-1.81). Conclusions: The IL-4 rs79071878 polymorphism, was associated whereas the IL-1Ra rs2234663 polymorphism was not associated with FMF risk in the Turkish population. Larger studies with different ethnicities are needed to determine the impact of IL-1Ra and IL-4 polymorphism on the risk of developing FMF. (C) 2016 Elsevier B.V. All rights reserved

Alternating facial paralysis in a girl with hypertension. Case report

Bell's palsy is the most common cause of acquried unilateral facial nerve palsy in childhood. Although the diagnosis depends on the exclusion of less common causes such as infectious, traumatic, malignancy associated and hypertension associated etiologies, pediatricians tend to diagnose idiopatic Bell's palsy whenever a child admits with acquired facial weakness. In this report, we present an eight year old girl, presenting with reccurent and alternant facial palsy as the first symptom of systemic hypertension. She had underwent steroid treatment without measuring blood pressure that could worsen hypertension. Clinicians should be aware of this association and not neglect to measure the blood pressure before considering steroid therapy for Bell's palsy. In addition, the less common causes of acquired facial palsy should be kept in mind, especially when reccurent and alternant courses occur