675 research outputs found
Generation and characterization of function-blocking anti-ectodysplasin A (EDA) monoclonal antibodies that induce ectodermal dysplasia.
Development of ectodermal appendages, such as hair, teeth, sweat glands, sebaceous glands, and mammary glands, requires the action of the TNF family ligand ectodysplasin A (EDA). Mutations of the X-linked EDA gene cause reduction or absence of many ectodermal appendages and have been identified as a cause of ectodermal dysplasia in humans, mice, dogs, and cattle. We have generated blocking antibodies, raised in Eda-deficient mice, against the conserved, receptor-binding domain of EDA. These antibodies recognize epitopes overlapping the receptor-binding site and prevent EDA from binding and activating EDAR at close to stoichiometric ratios in in vitro binding and activity assays. The antibodies block EDA1 and EDA2 of both mammalian and avian origin and, in vivo, suppress the ability of recombinant Fc-EDA1 to rescue ectodermal dysplasia in Eda-deficient Tabby mice. Moreover, administration of EDA blocking antibodies to pregnant wild type mice induced in developing wild type fetuses a marked and permanent ectodermal dysplasia. These function-blocking anti-EDA antibodies with wide cross-species reactivity will enable study of the developmental and postdevelopmental roles of EDA in a variety of organisms and open the route to therapeutic intervention in conditions in which EDA may be implicated
Ground state non-universality in the random field Ising model
Two attractive and often used ideas, namely universality and the concept of a
zero temperature fixed point, are violated in the infinite-range random-field
Ising model. In the ground state we show that the exponents can depend
continuously on the disorder and so are non-universal. However, we also show
that at finite temperature the thermal order parameter exponent one half is
restored so that temperature is a relevant variable. The broader implications
of these results are discussed.Comment: 4 pages 2 figures, corrected prefactors caused by a missing factor of
two in Eq. 2., added a paragraph in conclusions for clarit
Sialic acids on B cells are crucial for their survival and provide protection against apoptosis.
Sialic acids (Sias) on the B cell membrane are involved in cell migration, in the control of the complement system and, as sialic acid-binding immunoglobulin-like lectin (Siglec) ligands, in the regulation of cellular signaling. We studied the role of sialoglycans on B cells in a mouse model with B cell-specific deletion of cytidine monophosphate sialic acid synthase (CMAS), the enzyme essential for the synthesis of sialoglycans. Surprisingly, these mice showed a severe B cell deficiency in secondary lymphoid organs. Additional depletion of the complement factor C3 rescued the phenotype only marginally, demonstrating a complement-independent mechanism. The B cell survival receptor BAFF receptor was not up-regulated, and levels of activated caspase 3 and processed caspase 8 were high in B cells of Cmas-deficient mice, indicating ongoing apoptosis. Overexpressed Bcl-2 could not rescue this phenotype, pointing to extrinsic apoptosis. These results show that sialoglycans on the B cell surface are crucial for B cell survival by counteracting several death-inducing pathways
What does the rho-meson do? In-medium mass shift scenarios versus hadronic model calculations
The NA60 experiment has studied low-mass muon pair production in In-In
collisions at with unprecedented precision. With these results
there is hope that the in-medium modifications of the vector meson spectral
function can be constrained more thoroughly than before. We investigate in
particular what can be learned about collisional broadening by a hot and dense
medium and what constrains the experimental results put on in-medium mass shift
scenarios. The data show a clear indication of considerable in-medium
broadening effects but disfavor mass shift scenarios where the -meson
mass scales with the square root of the chiral condensate. Scaling scenarios
which predict at finite density a dropping of the -meson mass that is
stronger than that of the quark condensate are clearly ruled out since they are
also accompanied by a sharpening of the spectral function.Comment: Proceeding contribution, Talk given by J. Ruppert at Workshop for
Young Scientists on the Physics of Ultrarelativistic Nucleus-Nucleus
Collisions (Hot Quarks 2006), Villasimius, Sardinia, Italy, 15-20 May 2006.
To appear in EPJ
Deep seawater cooling and desalination: Combining seawater air conditioning and desalination
In tropical climates, the energy consumed by heating, ventilation and air conditioning can exceed 50% of the total energy consumption of a building. The demand for cooling is rising steadily, driven by global warming and rapidly increasing living standards in developing economies. In addition, there is a rise in water demand due to population increase, life quality, and global warming. Coastal areas with narrow continental shelves are the perfect site for implementing Seawater Air Conditioning (SWAC), a renewable and low CO2 emission cooling process. This article proposes the combination of SWAC and reverse osmosis (RO) desalination with the objective of providing desalinated cold water for integrated water supply and cooling services. This combination was named Deep Seawater Cooling and Desalination (DSCD). It was found that DSCD can supply 49 MWt of cooling and 1 m3/s of water simultaneously with an electricity consumption of 12 MWe. DSCD has several benefits compared to SWAC and RO individually, such as in how the cooling service and water supply are delivered together, reducing distribution costs. A case study was performed in Malé, Maldives. It shows that the technology has substantial potential to contribute to the sustainable development of tropical islands
Spatial correlations in vote statistics: a diffusive field model for decision-making
We study the statistics of turnout rates and results of the French elections
since 1992. We find that the distribution of turnout rates across towns is
surprisingly stable over time. The spatial correlation of the turnout rates, or
of the fraction of winning votes, is found to decay logarithmically with the
distance between towns. Based on these empirical observations and on the
analogy with a two-dimensional random diffusion equation, we propose that
individual decisions can be rationalised in terms of an underlying "cultural"
field, that locally biases the decision of the population of a given region, on
top of an idiosyncratic, town-dependent field, with short range correlations.
Using symmetry considerations and a set of plausible assumptions, we suggest
that this cultural field obeys a random diffusion equation.Comment: 18 pages, 5 figures; added sociophysics references
Classification of a supersolid: Trial wavefunctions, Symmetry breakings and Excitation spectra
A state of matter is characterized by its symmetry breaking and elementary
excitations.
A supersolid is a state which breaks both translational symmetry and internal
symmetry.
Here, we review some past and recent works in phenomenological
Ginsburg-Landau theories, ground state trial wavefunctions and microscopic
numerical calculations. We also write down a new effective supersolid
Hamiltonian on a lattice.
The eigenstates of the Hamiltonian contains both the ground state
wavefunction and all the excited states (supersolidon) wavefunctions. We
contrast various kinds of supersolids in both continuous systems and on
lattices, both condensed matter and cold atom systems. We provide additional
new insights in studying their order parameters, symmetry breaking patterns,
the excitation spectra and detection methods.Comment: REVTEX4, 19 pages, 3 figure
Comparison of some Reduced Representation Approximations
In the field of numerical approximation, specialists considering highly
complex problems have recently proposed various ways to simplify their
underlying problems. In this field, depending on the problem they were tackling
and the community that are at work, different approaches have been developed
with some success and have even gained some maturity, the applications can now
be applied to information analysis or for numerical simulation of PDE's. At
this point, a crossed analysis and effort for understanding the similarities
and the differences between these approaches that found their starting points
in different backgrounds is of interest. It is the purpose of this paper to
contribute to this effort by comparing some constructive reduced
representations of complex functions. We present here in full details the
Adaptive Cross Approximation (ACA) and the Empirical Interpolation Method (EIM)
together with other approaches that enter in the same category
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