25 research outputs found

    De ratione qvae inter Iordanem et Cassiodorivm intercedat commentatio

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    http://tartu.ester.ee/record=b1925105~S1*es

    Patkul und Leibnitz

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    https://www.ester.ee/record=b4005519*es

    Der Verfasser der livländischen Reimchronik

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    http://tartu.ester.ee/record=b1931814~S1*es

    Livländische Antwort an Herrn Juri Samarin

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    Korrigeerimata tekstituvastusegahttp://tartu.ester.ee/record=b1733029~S1*es

    Die Wandersagen der Neuseeländer und der Mauimythos

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    http://tartu.ester.ee/record=b2097079~S1*es

    Association of Hepatitis C Virus—Specific CD8+ T Cells with Viral Clearance in Acute Hepatitis C

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    CD8+ T lymphocytes play a major role in antiviral immune defense. Their significance for acute hepatitis C is unclear. Our aim was to correlate the CD8+ T cell response with the outcome of infection. Eighteen patients with acute hepatitis C and 19 normal donors were studied. Hepatitis C virus (HCV)—specific CD8+ T cells were identified in the enzyme-linked immunospot assay by their interferon-γ (IFN-γ) production after specific stimulation. The highest numbers of IFN-γ—producing HCV-specific CD8+ T cells were found in patients with acute hepatitis C and a self-limited course of disease during the first 6 months after onset of disease, but these numbers dropped thereafter to undetectable levels. The differences in responsiveness between patients with self-limited disease versus patients with a chronic course were statistically significant (P < .001). Our data show that the number of IFN—γ-producing HCV-specific CD8+ T cells during the first 6 months after onset of disease is associated with eradication of the HCV infectio
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