Migration, Marriage, and Social Mobility : Women in Sweden 1880-1900

We study the social mobility of women by looking at the connection between migration and marriage outcomes using complete count census data for Sweden. The censuses 1880-1900 have been linked at the individual level, enabling us to follow 100,000 women from their parental home to their new marital household. Marriage market imbalances were not an important push factor for migration but we find a strong association between migration distance and marriage outcomes, both in terms of overall marriage probabilities and in terms of partner selection. These results highlight the importance of migration for women’s social mobility during industrialization

Immigration and Child Mortality: Lessons from the United States at the Turn of the Twentieth Century

ABSTRACTThe societal integration of immigrants is a great concern in many of today's Western societies, and has been so for a long time. Whether we look at Europe in 2015 or the United States at the turn of the twentieth century, large flows of immigrants pose challenges to receiving societies. While much research has focused on the socioeconomic integration of immigrants there has been less interest in their demographic integration, even though this can tell us as much about the way immigrants fare in their new home country. In this article we study the disparities in infant and child mortality across nativity groups and generations, using new, high-density census data. In addition to describing differentials and trends in child mortality among 14 immigrant groups relative to the native-born white population of native parentage, we focus special attention on the association between child mortality, immigrant assimilation, and the community-level context of where immigrants lived. Our findings indicate substantial nativity differences in child mortality, but also that factors related to the societal integration of immigrants explains a substantial part of these differentials. Our results also point to the importance of spatial patterns and contextual variables in understanding nativity differentials in child mortality

Assessing the evolution of territorial disparities in health

The paper investigates spatio-temporal trends in health disparities through an empirical example. We deal with geographical health pattern in Italy from 1991 to 2010, starting from infant mortality data available at the provincial level and assessing the existent disparity among macro-regions (the conventional Northern, Central and Southern macro-regions). After a discussion concerning suitable inequality indices and their decompositions when dealing with small area data, we propose a model-based approach that allows to properly tackle sampling variability. Results give evidences of persisting spatial disparity in infant mortality along time

Variations in male height during the epidemiological transition in Italy: A cointegration approach

Background: The historical demography literature has a longstanding interest in establishing a connection between human body development and the living conditions experienced during infancy and childhood. Empirical research on such matters increasingly relies on survival indicators rather than classical economic measures of living standards, as the former are more directly linked to nutritional quality, material well-being levels, and technological development. Objective: We explore the relationship between epidemiological conditions and male adult height variation in Italy to understand if and to what extent progress in survival impacted human body evolution during the epidemiological transition. Methods: By exploiting the national military archive data from the Italian National Institute of Statistics and the Human Mortality Database, we focus on conscript cohorts born between 1872 and 1980 to connect average male height at the recruitment age with the prevailing infant and general survival conditions in the calendar year of conscripts' birth. We adopt an econometric approach based on cointegration analysis to study both the long- and the short-run relationships between the time series of interest. Results: Error correction model estimates find a positive link between epidemiological condition development and the secular increase in male height in Italy. Contribution: In the long run, as the probability of survival at the first birthday and life expectancy at 5 years increase, so does average male height. In the short term, however, we find an estimated inverse relationship between survival and stature, which we interpret as a counterintuitive mechanism of negative selection in the survival of the most fragile individuals both among infants and the general population

The societal burden of chronic liver diseases: results from the COME study.

OBJECTIVE: Chronic liver diseases (CLDs) impose a significant socioeconomic burden on patients and the healthcare system, but to what extent remains underexplored. We estimated costs and health-related-quality-of-life (HRQoL) among patients with CLDs at different stages and with different aetiologies. DESIGN: A cost-of-illness study was conducted. Direct costs, productivity loss and HRQoL were estimated in patients with chronic hepatitis, cirrhosis hepatocellular carcinoma (HCC) or where orthotopic liver transplantation (OLT) had been performed, for hepatitis C virus (HCV) infection, hepatitis B virus (HBV) infection, or in those with liver disease from other causes. Patients were retrospectively observed for 6 months. The societal perspective was adopted to calculate costs. RESULTS: In total, 1088 valid patients (median age=59.5 years, 60% men) were enrolled. 61% had chronic hepatitis, 20% cirrhosis, 8% HCC and 12% underwent OLT. HCV infection was identified in 52% and HBV infection in 29% of the patients. Adjusted mean direct costs increased from €3000/patient-month in HBV infected patients with OLT. Antiviral treatment was the cost driver in patients with hepatitis, while hospital costs were the driver in the other subgroups. Absenteeism increased from HBV-infected patients with hepatitis (0.7 day/patient-month) to patients with OLT with other aetiologies (3.7 days/patient-month). HRQoL was on average more compromised in cirrhosis and patients with HCC, than in hepatitis and patients with OLT. HBV-infected patients generated higher direct costs, patients with other aetiologies generated the highest productivity loss and HCV-infected patients reported the worst HRQoL levels. CONCLUSIONS: The present study can be considered a benchmark for future research and to guide policies aimed at maximising the cost-effective of the interventions

Clinical characteristics and molecular aspects of low-grade serous ovarian and peritoneal cancer: a multicenter, observational, retrospective analysis of MITO Group (MITO 22)

BACKGROUND: Low-grade serous ovarian and peritoneal cancer (LGSC) is a rare disease and few data on the clinical and genomic landscape have been published.METHODS: A retrospective analysis of patients diagnosed with LGSC between 1996 and 2019 was conducted in MITO centers. Objective Response Rate (ORR) to treatments, progression-free survival (PFS) and overall survival (OS) were assessed. Additionally, the tumor molecular profile of 56 patients was evaluated using the Next Generation Sequencing (NGS) FoundationOne CDX (Foundation Medicine (R)).RESULTS: A total of 128 patients with complete clinical data and pathologically confirmed diagnosis of LGSC were identified. ORR to first and subsequent therapies were 23.7% and 33.7%, respectively. PFS was 43.9 months (95% CI:32.4-53.1) and OS was 105.4 months (95% CI: 82.7-not reached). The most common gene alterations were: KRAS (n = 12, 21%), CDKN2A/B (n = 11, 20%), NRAS (n = 8, 14%), FANCA (n = 8, 14%), NF1 (n = 7, 13%) and BRAF (n = 6, 11%). Unexpectedly, pathogenetic BRCA1 (n = 2, 4%), BRCA2 (n = 1, 2%) and PALB2 (n = 1, 2%) mutations were found.CONCLUSIONS: MITO 22 suggests that LGSC is an heterogenous disease for both its clinical behavior in response to standard therapies and its molecular alterations. Future prospective studies should test treatments according to biological and molecular tumor's characteristics

Does socioeconomic status matter? The fertility transition in a northern Italian village (marriage cohorts 1900‒1940)

Background: The paper explores the mechanisms of the European fertility transition in northern Italy by social group. Objective: Our objective is to understand when and in which sectors of a rural society the reduction of family size began. We focus on Emilia-Romagna, a region that in the 1990s had the lowest fertility level in Italy. The core purpose of this paper is the analysis of socioeconomic status (SES) fertility differentials, especially between rural sharecroppers and landless rural workers, as well as other non-agricultural groups. Methods: Our analysis focuses on the reproductive histories of marriage cohorts in the years 1900‒1940. We perform a micro-level statistical analysis of legitimate births of parity 1+. Results: In this period fertility decline has just begun, and shows a strong decline in the post-WWI marriage cohorts. Although nonagricultural groups lead the downward trend in family size, the role of socioeconomic status means that the path of sharecropper households is atypical. Conclusions: The fertility transition proceeds by means of spacing and stopping, testifying to a new attitude towards birth control, which agricultural and nonagricultural social groups adopted in different ways. Usually, the decline in fertility progresses from nonagricultural to rural classes. In the rural world the path is inverted, going from the lower to the upper groups. Contribution: The paper contributes to the debate on the links between socioeconomic status and fertility transition in Italy. It shows that the link between household economy and control of fertility is specific to SES groups, which can follow atypical paths, compared to the known reference model. The use of microdemographic data provides evidence for the hypothesis that the fertility transition can be shaped by the specific social and economic characteristics of population subgroups

Oral ondansetron versus domperidone for acute gastroenteritis in pediatric emergency departments: Multicenter double blind randomized controlled trial

The use of antiemetics for vomiting in acute gastroenteritis in children is still a matter of debate. We conducted a double-blind randomized trial to evaluate whether a single oral dose of ondansetron vs domperidone or placebo improves outcomes in children with gastroenteritis. After failure of initial oral rehydration administration, children aged 1-6 years admitted for gastroenteritis to the pediatric emergency departments of 15 hospitals in Italy were randomized to receive one oral dose of ondansetron (0.15 mg/kg) or domperidone (0.5 mg/kg) or placebo. The primary outcome was the percentage of children receiving nasogastric or intravenous rehydration. A p value of 0.014 was used to indicate statistical significance (and 98.6% CI were calculated) as a result of having carried out two interim analyses. 1,313 children were eligible for the first attempt with oral rehydration solution, which was successful for 832 (63.4%); 356 underwent randomization (the parents of 125 children did not give consent): 118 to placebo, 119 to domperidone, and 119 to ondansetron. Fourteen (11.8%) needed intravenous rehydration in the ondansetron group vs 30 (25.2%) and 34 (28.8%) in the domperidone and placebo groups, respectively. Ondansetron reduced the risk of intravenous rehydration by over 50%, both vs placebo (RR 0.41, 98.6% CI 0.20-0.83) and domperidone (RR 0.47, 98.6% CI 0.23-0.97). No differences for adverse events were seen among groups. In a context of emergency care, 6 out of 10 children aged 1-6 years with vomiting due to gastroenteritis and without severe dehydration can be managed effectively with administration of oral rehydration solution alone. In children who fail oral rehydration, a single oral dose of ondansetron reduces the need for intravenous rehydration and the percentage of children who continue to vomit, thereby facilitating the success of oral rehydration. Domperidone was not effective for the symptomatic treatment of vomiting during acute gastroenteritis