Novel, Efficacious Antibiotics Produced by Bacillus subtilis DB9011

Antibiotic activities of the Bacillus subtilis DB9011 culture supernatant extracts against 52 pathogenic microbes were screened by measuring the zone of growth inhibition of the pathogens under a sterile paper disc loaded with the supernatant extract. The first scientific evidence for the effectiveness of the DB9011 culture extract against Porphyromonas gingivalis, Clostridium difficile, Propionibacterium acnes, and Legionella pneumophila is presented here. These organisms are causative pathogens of periodontal disease, Clostridium difficile-associated colitis, acne, and pneumonia, respectively. The findings from the present study will contribute to the development of more efficacious and safer pharmacotherapeutic agents for these diseases

Endoscopic Treatment of Sinonasal Glomangiopericytoma: A Case Report in Light of the Literature

A 71-year-old Japanese male patient presented with a rare case of Glomangiopericytoma (GPC) of the left nasal with obstruction. Complete resection with endoscopic surgery was performed. Immunohistochemical staining for smooth muscle actin, β catenin, cyclin D1, vimentin, and factor 13 were helpful in establishing a definitive diagnosis. Extranasal treatment has been traditionally performed for successful management. However, recent advances in endoscopic treatment have enabled complete endoscopic resection of GPC, minimizing morbidity and facilitating subsequent surveillance for recurrence. Endoscopic management should be considered in suitable cases

Polyamine Distribution Patterns in Pseudomonas, Alcaligenes and Comamonas

Pseudomonas cepacia as well as all five Alcaligenes and three Comamonas species tested belonging to the beta subclass of Proteobacteria ubiquitously contained 2-hydroxyputrescine and putrescine as the major polyamines. Cadaverine was found in P. cepacia. Putrescine and spermidine were the major polyamines of Pseudomonas aeruginosa and Pseudomonas putida belonging to the gamma subclass and Pseudomonas saccharophila whose taxonomic positions have not been established. Polyamine distribution profiles can serve as a chemotaxonomic marker within Pseudomonas species. Relative distribution patterns of the major polyamines of P. aeruginosa did not changed at different culture periods in spite of increase or decrease of their levels during growth