Overview of diagnosis and management of paediatric headache. Part I: diagnosis

Headache is the most common somatic complaint in children and adolescents. The evaluation should include detailed history of children and adolescents completed by detailed general and neurological examinations. Moreover, the possible role of psychological factors, life events and excessively stressful lifestyle in influencing recurrent headache need to be checked. The choice of laboratory tests rests on the differential diagnosis suggested by the history, the character and temporal pattern of the headache, and the physical and neurological examinations. Subjects who have any signs or symptoms of focal/progressive neurological disturbances should be investigated by neuroimaging techniques. The electroencephalogram and other neurophysiological examinations are of limited value in the routine evaluation of headaches. In a primary headache disorder, headache itself is the illness and headache is not attributed to any other disorder (e.g. migraine, tension-type headache, cluster headache and other trigeminal autonomic cephalgias). In secondary headache disorders, headache is the symptom of identifiable structural, metabolic or other abnormality. Red flags include the first or worst headache ever in the life, recent headache onset, increasing severity or frequency, occipital location, awakening from sleep because of headache, headache occurring exclusively in the morning associated with severe vomiting and headache associated with straining. Thus, the differential diagnosis between primary and secondary headaches rests mainly on clinical criteria. A thorough evaluation of headache in children and adolescents is necessary to make the correct diagnosis and initiate treatment, bearing in mind that children with headache are more likely to experience psychosocial adversity and to grow up with an excess of both headache and other physical and psychiatric symptoms and this creates an important healthcare problem for their future life

Physical and perceptional oral health status of children with hemophilia A

WOS: 000279994100279

Severe alveolar bone loss and gingival hyperplasia as initial manifestation of burkitt cell type acute lymphoblastic leukemia

PubMedID: 12747461Background: The purpose of this case report is to present severe alveolar bone destruction and gingival enlargement as initial manifestation of Burkitt cell type acute lymphoblastic leukemia (ALL-L3) in a 14-year-old boy. Methods: The patient was referred to the periodontology department with a 4-week history of gingival enlargement and loosening of teeth. The clinical examination revealed gingival enlargement and expansion of alveolar mucosa particularly in molar regions of both jaws. Almost all teeth had deep periodontal pockets and severe mobility. While the radiographs showed severe alveolar bone loss which extended to apical thirds of many teeth, the microbiologic analysis revealed that the patient did not harbor major periodontopathogenic bacteria species. The results of blood tests and bone marrow aspiration were compatible with ALL-L3. Results: Remission-induction treatment with BFM-90 ALL chemotherapy protocol was started; however, the patient died 4 weeks after the diagnosis due to neutropenic sepsis. Conclusions: Although no biopsy was performed, it is possible that the severe periodontal destruction and gingival enlargement in this case may have been due to the infiltration of leukemic cells in gingiva, periodontal ligament, and alveolar bone. The similarities of these findings with numb chin syndrome (NCS) and Burkitt's lymphoma (BL) are discussed in this report

Stroke in sickle cell anemia

WOS: 000075031300697

Defibrotide for the prevention and treatment of hepatic veno-occlusive disease after hematopoietic stem cell transplantation: a single-center experience

43rd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT) -- MAR 26-29, 2017 -- Marseille, FRANCEWOS: 000424355301407…European Soc Blood & Marrow Transplanta

The prophylaxis and the treatment of hepatic veno-occlusive disease after pediatric hematopoetic stem cell transplantation: our single-centre experience

10th Eurasian Hematology Oncology Congress -- OCT 08-11, 2019 -- Istanbul, TURKEYWOS: 000489290100006

Haploidentical stem cell transplantation in children; a single center experience of alpha beta T-cell depleted and unmanipulated transplantation with post-transplant cyclophosphamide

43rd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT) -- MAR 26-29, 2017 -- Marseille, FRANCEWOS: 000424355301415…European Soc Blood & Marrow Transplanta