398 research outputs found
Strategies to Improve Project Management Maturity Processes
Information technology organizations lose significant competitive value when business leaders fail to use project management maturity (PMM) processes that enhance market delivery, reduce costs, and increase profitability. Using a multiple-case study, the researcher explored strategies that project leaders have used to improve PMM processes and expanded upon Kerzner\u27s PMM model, which comprises 5 PMM levels essential for achieving repeatable project success. The researcher selected 20 project leader participants in the Southeastern region of the United States using a purposeful snowball sampling technique. In depth interviews were combined with archival and document exploration using a multiple-case study design where different types of project offices were cross compared as the unit of analysis including governmental, corporate, nonprofit, and not-for-profit organizations. Thematic analysis and cross-case analysis revealed 6 major strategies to improve PMM processes: project leader development, customer focus, standard methodology development, interactive communication, establishing a project office organizational structure, and practicing continuous process improvement. The implications for positive social change include the potential to provide small businesses and marginally-resourced organizations, such as churches and charitable organizations, with a beneficial value that contributes to positive economic activity in the local communities they support. The results are important because they extend constrained resources and organizational buying power for deliverables required by the recipient of the altruistic act
Book Reviews
Reviews of the following books: Black Bangor: African Americans in a Maine Community, 1880-1950 by Maureen Elgersman Lee; Through a Howling Wilderness: Benedict Arnold\u27s March to Quebec, 1775 by Thomas A. Desjardin; Marsden Hartley: Race, Religion and Nation by Donna M. Cassidy; Saints and Strangers: New England in British North America by Joseph A. Confort
Current Oncological Treatment of Patients with Pancreatic Cancer in Germany: Results from a National Survey on behalf of the Arbeitsgemeinschaft Internistische Onkologie and the Chirurgische Arbeitsgemeinschaft Onkologie of the Germany Cancer Society
Background: No data have previously been available regarding the current treatment of patients with pancreatic cancer (PC) in German hospitals and medical practices. Methods: Between February 2007 and March 2008 we conducted a national survey {[}on behalf of the Arbeitsgemeinschaft Internistische Onkologie (AIO) and the Chirurgische Arbeitsgemeinschaft Onkologie (CAO)] regarding the current surgical and oncological treatment of PC in Germany. Standardized questionnaires were sent via mailing lists to members of the AIO and CAO (n = 1,130). The data were analyzed using SPSS software (version 16.0). Pre-defined subgroup analysis was performed by grouping the results of each question with regard to the professional site of the responding physician and to the number of patients treated in their institution by year. Results: 181 (16%) of the oncological questionnaires were sent back. For 61% of the participating centers, a histological confirmation of PC diagnosis is obligatory. 21% of physicians offer neoadjuvant therapy to patients with potentially resectable PC. In the adjuvant treatment after curative-intent surgery, gemcitabine (Gem) is regarded as standard of care by 71% after R0 resection and 62% after R1 resection. For patients with locally advanced PC, 52% of the participating centers recommend systemic chemotherapy, 17% prefer combined primary chemoradiotherapy. Most centers (59%) base their decision of combination regimens for metastatic disease on the performance status of their patients. In patients with a good status, 28% apply single-agent Gem, 3% use Gem + capecitabine, 12% Gem + erlotinib, 16% Gem + oxaliplatin, and 8% Gem + cisplatin. Only 28% of the survey doctors offer second-line treatment to the majority of their patients with advanced PC. Conclusion: Not every PC patient in Germany is treated according to the present S3 guidelines. Diagnosis and treatment of PC in Germany still need to be improved. Copyright (C) 2009 S. Karger AG, Base
COLDz: Karl G. Jansky Very Large Array discovery of a gas-rich galaxy in COSMOS
The broad spectral bandwidth at mm and cm-wavelengths provided by the recent upgrades to the Karl G. Jansky Very Large Array (VLA) has made it possible to conduct unbiased searches for molecular CO line emission at redshifts, z > 1.31. We present the discovery of a gas-rich, star-forming galaxy at z = 2.48, through the detection of CO(1-0) line emission in the COLDz survey, through a sensitive, Ka-band (31 to 39 GHz) VLA survey of a 6.5 square arcminute region of the COSMOS field. We argue that the broad line (FWHM ~570 +/- 80 km/s) is most likely to be CO(1-0) at z=2.48, as the integrated emission is spatially coincident with an infrared-detected galaxy with a photometric redshift estimate of z = 3.2 +/- 0.4. The CO(1-0) line luminosity is L'_CO = (2.2 +/- 0.3) x 10^{10} K km/s pc^2, suggesting a cold molecular gas mass of M_gas ~ (2 - 8)x10^{10}M_solar depending on the assumed value of the molecular gas mass to CO luminosity ratio alpha_CO. The estimated infrared luminosity from the (rest-frame) far-infrared spectral energy distribution (SED) is L_IR = 2.5x10^{12} L_solar and the star-formation rate is ~250 M_solar/yr, with the SED shape indicating substantial dust obscuration of the stellar light. The infrared to CO line luminosity ratio is ~114+/-19 L_solar/(K km/s pc^2), similar to galaxies with similar SFRs selected at UV/optical to radio wavelengths. This discovery confirms the potential for molecular emission line surveys as a route to study populations of gas-rich galaxies in the future
CO(1-0) line imaging of massive star-forming disc galaxies at z=1.5-2.2
We present detections of the CO(J= 1-0) emission line in a sample of four massive star-forming galaxies at z~1.5-2.2 obtained with the Karl G. Jansky Very Large Array (VLA). Combining these observations with previous CO(2-1) and CO(3-2) detections of these galaxies, we study the excitation properties of the molecular gas in our sample sources. We find an average line brightness temperature ratios of R_{21}=0.70+\-0.16 and R_{31}=0.50+\-0.29, based on measurements for three and two galaxies, respectively. These results provide additional support to previous indications of sub-thermal gas excitation for the CO(3-2) line with a typically assumed line ratio R_{31}~0.5. For one of our targets, BzK-21000, we present spatially resolved CO line maps. At the resolution of 0.18'' (1.5 kpc), most of the emission is resolved out except for some clumpy structure. From this, we attempt to identify molecular gas clumps in the data cube, finding 4 possible candidates. We estimate that <40 % of the molecular gas is confined to giant clumps (~1.5 kpc in size), and thus most of the gas could be distributed in small fainter clouds or in fairly diffuse extended regions of lower brightness temperatures than our sensitivity limit
A molecular line scan in the Hubble Deep Field North
We present a molecular line scan in the Hubble Deep Field North (HDF-N) that covers the entire 3mm window (79-115 GHz) using the IRAM Plateau de Bure Interferometer. Our CO redshift coverage spans z2. We reach a CO detection limit that is deep enough to detect essentially all z>1 CO lines reported in the literature so far. We have developed and applied different line searching algorithms, resulting in the discovery of 17 line candidates. We estimate that the rate of false positive line detections is ~2/17. We identify optical/NIR counterparts from the deep ancillary database of the HDF-N for seven of these candidates and investigate their available SEDs. Two secure CO detections in our scan are identified with star-forming galaxies at z=1.784 and at z=2.047. These galaxies have colors consistent with the `BzK' color selection and they show relatively bright CO emission compared with galaxies of similar dust continuum luminosity. We also detect two spectral lines in the submillimeter galaxy HDF850.1 at z=5.183. We consider an additional 9 line candidates as high quality. Our observations also provide a deep 3mm continuum map (1-sigma noise level = 8.6 μJy/beam). Via a stacking approach, we find that optical/MIR bright galaxies contribute only to <50% of the SFR density at 1<z<3, unless high dust temperatures are invoked. The present study represents a first, fundamental step towards an unbiased census of molecular gas in `normal' galaxies at high-z, a crucial goal of extragalactic astronomy in the ALMA era
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