3 research outputs found
Design of Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@Carbon Quantum Dot Based Nanostructure for Fluorescence Sensing, Magnetic Separation, and Live Cell Imaging of Fluoride Ion
A robust
reusable fluoride sensor comprised of a receptor in charge of the
chemical recognition and a fluorophore responsible for signal recognition
has been designed. Highly fluorescent carbon quantum dot (CD) and
magnetically separable nickel ethyleneÂdiamineÂtetraacetic
acid (EDTA) complex bound-silica coated magnetite nanoparticle (Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>–EDTA–Ni) have
been used as fluorophore and fluoride ion receptor, respectively.
The assay is based on the exchange reaction between the CD and F<sup>–</sup>, which persuades the binding of fluoride to magnetic
receptor. This method is highly sensitive, fast, and selective for
fluoride ion in aqueous solution. The linear response range of fluoride
(<i>R</i><sup>2</sup> = 0.992) was found to be 1–20
μM with a minimum detection limit of 0.06 μM. Excellent
magnetic property and superparamagnetic nature of the receptor are
advantageous for the removal and well quantification of fluoride ion.
The practical utility of the method is well tested with tap water.
Because of high sensitivity, reusability, effectivity, and biocompatibility,
it exhibits great promise as a fluorescent probe for intracellular
detection of fluoride
Design of Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>@Carbon Quantum Dot Based Nanostructure for Fluorescence Sensing, Magnetic Separation, and Live Cell Imaging of Fluoride Ion
A robust
reusable fluoride sensor comprised of a receptor in charge of the
chemical recognition and a fluorophore responsible for signal recognition
has been designed. Highly fluorescent carbon quantum dot (CD) and
magnetically separable nickel ethyleneÂdiamineÂtetraacetic
acid (EDTA) complex bound-silica coated magnetite nanoparticle (Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub>–EDTA–Ni) have
been used as fluorophore and fluoride ion receptor, respectively.
The assay is based on the exchange reaction between the CD and F<sup>–</sup>, which persuades the binding of fluoride to magnetic
receptor. This method is highly sensitive, fast, and selective for
fluoride ion in aqueous solution. The linear response range of fluoride
(<i>R</i><sup>2</sup> = 0.992) was found to be 1–20
μM with a minimum detection limit of 0.06 μM. Excellent
magnetic property and superparamagnetic nature of the receptor are
advantageous for the removal and well quantification of fluoride ion.
The practical utility of the method is well tested with tap water.
Because of high sensitivity, reusability, effectivity, and biocompatibility,
it exhibits great promise as a fluorescent probe for intracellular
detection of fluoride
Highly Hydrophilic Luminescent Magnetic Mesoporous Carbon Nanospheres for Controlled Release of Anticancer Drug and Multimodal Imaging
Judicious combination of fluorescence
and magnetic properties along
with ample drug loading capacity and control release property remains
a key challenge in the design of nanotheranostic agents. This paper
reports the synthesis of highly hydrophilic optically traceable mesoporous
carbon nanospheres which can sustain payloads of the anticancer drug
doxorubicin and T2 contrast agent such as cobalt ferrite nanoparticles.
The luminescent magnetic hybrid system has been prepared on a mesoporous
silica template using a resorcinol-formaldehyde precursor. The mesoporous
matrix shows controlled release of the aromatic drug doxorubicin due
to disruption of supramolecular π–π interaction
at acidic pH. The particles show MR contrast behavior by affecting
the proton relaxation with transverse relaxivity (<i>r</i><sub>2</sub>) 380 mM<sup>–1</sup> S<sup>–1</sup>. The
multicolored emission and upconversion luminescence property of our
sample are advantageous in bioimaging. In vitro cell experiments shows
that the hybrid nanoparticles are endocyted by the tumor cells through
passive targeting. The pH-responsive release of doxorubicin presents
chemotherapeutic inhibition of cell growth through induction of apoptosis