315 research outputs found
An archival case study : revisiting the life and political economy of Lauchlin Currie
This paper forms part of a wider project to show the significance of archival material on distinguished economists, in this case Lauchlin Currie (1902-93), who studied and taught at Harvard before entering government service at the US Treasury and Federal Reserve Board as the intellectual leader of Roosevelt's New Deal, 1934-39, as FDR's White House economic adviser in peace and war, 1939-45, and as a post-war development economist. It discusses the uses made of the written and oral material available when the author was writing his intellectual biography of Currie (Duke University Press 1990) while Currie was still alive, and the significance of the material that has come to light after Currie's death
Fabrication and Characterization of Topological Insulator BiSe Nanocrystals
In the recently discovered class of materials known as topological
insulators, the presence of strong spin-orbit coupling causes certain
topological invariants in the bulk to differ from their values in vacuum. The
sudden change of invariants at the interface results in metallic, time reversal
invariant surface states whose properties are useful for applications in
spintronics and quantum computation. However, a key challenge is to fabricate
these materials on the nanoscale appropriate for devices and probing the
surface. To this end we have produced 2 nm thick nanocrystals of the
topological insulator BiSe via mechanical exfoliation. For crystals
thinner than 10 nm we observe the emergence of an additional mode in the Raman
spectrum. The emergent mode intensity together with the other results presented
here provide a recipe for production and thickness characterization of
BiSe nanocrystals.Comment: 4 pages, 3 figures (accepted for publication in Applied Physics
Letters
X-ray Absorption Spectroscopy Study of the Effect of Rh Doping in Sr\u3csub\u3e2\u3c/sub\u3eIrO\u3csub\u3e4\u3c/sub\u3e
We investigate the effect of Rh doping in Sr2IrO4 using X-ray absorption spectroscopy (XAS). We observed appearance of new electron-addition states with increasing Rh concentration (x in Sr2Ir1âxRhxO4) in accordance with the concept of hole doping. The intensity of the hole-induced state is however weak, suggesting weakness of charge transfer (CT) effect and Mott insulating ground states. Also, Ir Jeffâ=â1/2 upper Hubbard band shifts to lower energy as x increases up to xâ=â0.23. Combined with optical spectroscopy, these results suggest a hybridisation-related mechanism, in which Rh doping can weaken the (Ir Jeffâ=â1/2)â(O 2p) orbital hybridisation in the in-planar Rh-O-Ir bond networks
Optical evidence of surface state suppression in Bi based topological insulators
A key challenge in condensed matter research is the optimization of
topological insulator (TI) compounds for the study and future application of
their unique surface states. Truly insulating bulk states would allow the
exploitation of predicted surface state properties, such as protection from
backscattering, dissipationless spin-polarized currents, and the emergence of
novel particles. Towards this end, major progress was recently made with the
introduction of highly resistive BiTeSe, in which surface state
conductance and quantum oscillations are observed at low temperatures.
Nevertheless, an unresolved and pivotal question remains: while room
temperature ARPES studies reveal clear evidence of TI surface states, their
observation in transport experiments is limited to low temperatures. A better
understanding of this surface state suppression at elevated temperatures is of
fundamental interest, and crucial for pushing the boundary of device
applications towards room-temperature operation. In this work, we
simultaneously measure TI bulk and surface states via temperature dependent
optical spectroscopy, in conjunction with transport and ARPES measurements. We
find evidence of coherent surface state transport at low temperatures, and
propose that phonon mediated coupling between bulk and surface states
suppresses surface conductance as temperature rises.Comment: 13 pages, 10 figure
Hospital usage of TOXBASE in Great Britain:Temporal trends in accesses 2008 to 2015
Aim: Examining temporal trends in accesses to the UK's National Poison Information Service's TOXBASE database in Britain. Methods: Generalised additive models were used to examine trends in daily numbers of accesses to TOXBASE from British emergency departments between January 2008 and December 2015. Day-of-the-week, seasonality and long term trends were analysed at national and regional levels (Wales, Scotland and the 9 English Government Office Regions). Results: The long-term trend in daily accesses increases from 2.8 (95% CI:2.6, 3.0) per user on 1st January 2008 to 4.6 (95% CI:4.3, 4.9) on 31st December 2015, with small but significant differences in population-corrected accesses by region (p<0.001). There are statistically significant seasonal and day of the week patterns (p<0.001) across all regions. Accesses are 18 % (95% CI:14%, 22%) higher in summer than in January and at the weekend compared to weekdays in all regions; there is a 7.5% (95% CI:6.1%, 8.9%) increase between Friday and Sunday. Conclusions: There are consistent in-year patterns in access to TOXBASE indicating potential seasonal patterns in poisonings in Britain, with location-dependant rates of usage. This novel descriptive work lays the basis for future work on the interaction of TOXBASE use with emergency admission of patients into hospital
Fermionic response from fractionalization in an insulating two-dimensional magnet
Conventionally ordered magnets possess bosonic elementary excitations, called
magnons. By contrast, no magnetic insulators in more than one dimension are
known whose excitations are not bosons but fermions. Theoretically, some
quantum spin liquids (QSLs) -- new topological phases which can occur when
quantum fluctuations preclude an ordered state -- are known to exhibit Majorana
fermions as quasiparticles arising from fractionalization of spins. Alas,
despite much searching, their experimental observation remains elusive. Here,
we show that fermionic excitations are remarkably directly evident in
experimental Raman scattering data across a broad energy and temperature range
in the two-dimensional material -RuCl. This shows the importance of
magnetic materials as hosts of Majorana fermions. In turn, this first
systematic evaluation of the dynamics of a QSL at finite temperature emphasizes
the role of excited states for detecting such exotic properties associated with
otherwise hard-to-identify topological QSLs.Comment: 5 pages, 3 figure
FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells
Receptor Tyrosine Kinases (RTKs) and Focal Adhesion Kinase (FAK) regulate multiple signalling pathways, including mitogen-activated protein (MAP) kinase pathway. FAK interacts with several RTKs but little is known about how FAK regulates their downstream signalling. Here we investigated how FAK regulates signalling resulting from the overexpression of the RTKs RET and EGFR. FAK suppressed RTKs signalling in Drosophila melanogaster epithelia by impairing MAPK pathway. This regulation was also observed in MDA-MB-231 human breast cancer cells, suggesting it is a conserved phenomenon in humans. Mechanistically, FAK reduced receptor recycling into the plasma membrane, which resulted in lower MAPK activation. Conversely, increasing the membrane pool of the receptor increased MAPK pathway signalling. FAK is widely considered as a therapeutic target in cancer biology; however, it also has tumour suppressor properties in some contexts. Therefore, the FAK-mediated negative regulation of RTK/MAPK signalling described here may have potential implications in the designing of therapy strategies for RTK-driven tumours
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