No Second Chance to Make a First Impression: The “Thin‐Slice” Effect on Instructor Ratings and Learning Outcomes in Higher Education

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134071/1/jedm12116_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/134071/2/jedm12116.pd

Determination of Andrographolide Isolate Activity to α-Amylase and α-Glucosidase Using Apostolidis and Mayur Method

Disorders of carbohydrate metabolism can lead to diabetes mellitus. Carbohydrates are metabolized in the gastrointestinal tract into simple glucose and absorbed into the bloodstream and affected blood glucose levels. The absorption process is catalyzed by α- 1 ,4 - glycoside breaking bond enzyme , namely α - amylase and α -1 ,6 - glycoside breaking bond enzyme, namely α – glucosidase. They are found in the intestinal cells. Research had been conducted in an effort to develop an alternative treatment of diabetes mellitus by testing the ability of isolates of andrographolide in inhibiting α-amylase activity and α-glucosidase in vitro. Andrographolide isolates showed fairly good activity in inhibiting α-amylase ( IC50 = 1,.49 mg/mL) and weak in inhibiting α-glucosidase (IC50 = 38,86 mg/mL). Inhibition of α-amylase activity is evidence of one mechanism of andrographolide in reducing carbohydrate metabolism that can affect blood glucose levels and indicates that andrographolide is a potential alternative medicine in addressing diabetes mellitus

Smooth muscle archvillin: a novel regulator of signaling and contractility in vascular smooth muscle

The mechanisms by which protein kinase C (PKC) and extracellular-signal-regulated kinases (ERK1/2) govern smooth-muscle contractility remain unclear. Calponin (CaP), an actin-binding protein and PKC substrate, mediates signaling through ERK1/2. We report here that CaP sequences containing the CaP homology (CH) domain bind to the C-terminal 251 amino acids of smooth-muscle archvillin (SmAV), a new splice variant of supervillin, which is a known actin- and myosin-II-binding protein. The CaP-SmAV interaction is demonstrated by reciprocal yeast two-hybrid and blot-overlay assays and by colocalization in COS-7 cells. In differentiated smooth muscle, endogenous SmAV and CaP co-fractionate and co-translocate to the cell cortex after stimulation by agonist. Antisense knockdown of SmAV in tissue inhibits both the activation of ERK1/2 and contractions stimulated by either agonist or PKC activation. This ERK1/2 signaling and contractile defect is similar to that observed in CaP knockdown experiments. In A7r5 smooth-muscle cells, PKC activation by phorbol esters induces the reorganization of endogenous, membrane-localized SmAV and microfilament-associated CaP into podosome-like structures that also contain F-actin, nonmuscle myosin IIB and ERK1/2. These results indicate that SmAV contributes to the regulation of contractility through a CaP-mediated signaling pathway, involving PKC activation and phosphorylation of ERK1/2

Effect of Curcumin and Honey to Pharmacokinetics of Paracetamol in Male Wistar Rats

Honey and curcumin is widely consumed by children as food supplements. Honey is useful as an antioxidant and antibacterial, while curcumin is useful as an antioxidant, antiinflammatory, antibacterial, antiviral. Both health supplements are not infrequently used in conjunction with drugs, especially paracetamol. This study aims to determine the effect of curcumin and honey on the pharmacokinetic parameters of paracetamol in male rats. In this study, test animals were divided into 3 groups: control, treatment I and treatment II. In the control group mice were given paracetamol 150mg / KgBW, treatment group I rats were given curcumin 18 mg / KgBW, 1 hour and then given paracetamol 150mg / KgBW whereas the treatment group II rats given a dose of honey 7.65 mL / KgBW along with giving paracetamol 150mg KgBB . The results showed that administration of curcumin on the pharmacokinetics of paracetamol in mice can decrease the primary parameters of the elimination phase of CLT for 68.25%, increasing the secondary parameter t 1 / 2 at 193.72%, thus increasing the derivative parameters AUC0-inf for 88.36%, and MRT of 155.17% (

Connectomic markers of disease expression, genetic risk and resilience in bipolar disorder.

Bipolar disorder (BD) is characterized by emotional dysregulation and cognitive deficits associated with abnormal connectivity between subcortical-primarily emotional processing regions-and prefrontal regulatory areas. Given the significant contribution of genetic factors to BD, studies in unaffected first-degree relatives can identify neural mechanisms of genetic risk but also resilience, thus paving the way for preventive interventions. Dynamic causal modeling (DCM) and random-effects Bayesian model selection were used to define and assess connectomic phenotypes linked to facial affect processing and working memory in a demographically matched sample of first-degree relatives carefully selected for resilience (n=25), euthymic patients with BD (n=41) and unrelated healthy controls (n=46). During facial affect processing, patients and relatives showed similarly increased frontolimbic connectivity; resilient relatives, however, evidenced additional adaptive hyperconnectivity within the ventral visual stream. During working memory processing, patients displayed widespread hypoconnectivity within the corresponding network. In contrast, working memory network connectivity in resilient relatives was comparable to that of controls. Our results indicate that frontolimbic dysfunction during affect processing could represent a marker of genetic risk to BD, and diffuse hypoconnectivity within the working memory network a marker of disease expression. The association of hyperconnectivity within the affect-processing network with resilience to BD suggests adaptive plasticity that allows for compensatory changes and encourages further investigation of this phenotype in genetic and early intervention studies

Perancangan Dan Analisis Statis Ban Tanpa Udara (Airless Tire) Untuk Ukuran 165/60 R12

Electric cars have large torque from the start driven or acceleration. The use of conventional tires on electric cars can accelerate tire surface wear. Airless tires can be applied to electric cars, such as those being developed by the Bridgestone and Micheline tire companies. This research was conducted to determine, predict stress, displacement, strain and safety factor values and evaluate the design results through FEA simulations of the airless tire model. The contribution to be achieved in this research is to redesign to improve the stress, displacement, strain and safety factor of the airless tire model that has been previously studied. In this study, airless tire planned with size 165/60 R12 refers to the ETRTO standard. The airless tire model is visualized using the AutoCAD and CATIA software. The FEA (Finite Element Analysis) simulation is done with SOLIDWORKS. The honeycomb structure uses polyurethane as the main honeycomb component suitable for pneumatic tire replacement. The 4 planned honeycomb models show better stress, displacement, strain and safety factors compared to the comparative airless tire model previously examined

Sub-0.1-eV effective Schottky-barrier height for NiSi on n-type Si (100) using antimony segregation

10.1109/LED.2007.901668IEEE Electron Device Letters288703-705EDLE

Selenium segregation for lowering the contact resistance in ultrathin-body MOSFETs with fully metallized source/drain

10.1109/LED.2009.2028660IEEE Electron Device Letters30101087-1089EDLE

Effective Schottky Barrier height reduction using sulfur or selenium at the NiSi/n-Si (100) interface for low resistance contacts

10.1109/LED.2007.910003IEEE Electron Device Letters28121102-1104EDLE