31 research outputs found
AquaData and AquaGIS: Two computer utilities for temporal and spatial simulations of water-limited yield with AquaCrop
KARYOTYPE ALTERATIONS AFTER HYBRIDIZATION BETWEEN Pennisetum purpureum AND Pennisetum glaucum
Welsh Liberalism, 1868-1896 A study in political structure and ideology
SIGLEAvailable from British Library Lending Division - LD:D53868/85 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
C400. A Tentative measure of probabilistic causation relevant to the philosophy of the law
Causal Foundationalism, Physical Causation, and Difference-Making
An influential tradition in the philosophy of causation has it that all token causal facts are, or are reducible to, facts about difference-making. Challenges to this tradition have typically focused on pre-emption cases, in which a cause apparently fails to make a difference to its effect. However, a novel challenge to the difference-making approach has recently been issued by Alyssa Ney. Ney defends causal foundationalism, which she characterizes as the thesis that facts about difference-making depend upon facts about physical causation. She takes this to imply that causation is not fundamentally a matter of difference-making. In this paper, I defend the difference-making approach against Neyâs argument. I also offer some positive reasons for thinking, pace Ney, that causation is fundamentally a matter of difference-making
Public health policy, evidence, and causation. Lessons from the studies on obesity
The paper addresses the question of how different types of evidence ought to inform public health policy. By analysing case studies on obesity, the paper draws lessons about the different roles that different types of evidence play in setting up public health policies. More specifically, it is argued that evidence of difference-making supports considerations about âwhat works for whom in what circumstancesâ, and that evidence of mechanisms provides information about the âcausal pathwaysâ to intervene upon
The inferential basis of species hypotheses: the solution to defining the term 'species'
Aristolochic acid induces proximal tubule apoptosis and epithelial to mesenchymal transformation.
Aristolochic acid contamination in herbal remedies leads to interstitial fibrosis, tubular atrophy, and renal failure in humans. To study the cellular mechanisms contributing to the pathophysiology of this renal disease, we studied Wistar rats treated with aristolochic acid and measured tubular and interstitial cell proliferation, epithelial/mesenchymal cell marker expression, tubular membrane integrity, myofibroblast accumulation, oxidative stress, mitochondrial damage, tubular apoptosis, and fibrosis. Oxidative stress, a loss of cadherin concomitant with vimentin expression, basement membrane denudation with active caspase-3 expression, and mitochondrial injury within tubular cells were evident within 5 days of administration of the toxin. During the chronic phase, interstitial mesenchymal cells accumulated in areas of collagen deposits. Impaired regeneration and apoptosis of proximal tubular cells resulted in tubule atrophy with a near absence of dedifferentiated cell transmembrane migration. We suggest that resident fibroblast activation plays a critical role in the process of renal fibrosis during aristolochic acid toxicity.Journal ArticleResearch Support, Non-U.S. Gov'tinfo:eu-repo/semantics/publishe