3,233 research outputs found

    Liquid crystal VAN tilt bias by surface relief patterning

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    Liquid Crystal Displays require controlled alignment of the liquid crystal molecular director at its confining surfaces. These surfaces may be coated glass or in the case of 'Liquid Crystal On Silicon' (LCOS) technology, a silicon backplane. In the case of Vertically Aligned Nematic (VAN) cells an initially vertical orientation is used and from this the director may tilt in any direction. Some means is required to bias the tilt in a consistent direction to avoid the occurrence of differently oriented domains. For VAN cells one tilt bias method is oblique deposition of silicon oxide. An alternative method which eliminates concerns over consistency of deposition angle over a large substrate area is the use of surface relief structures to induce tilt bias. This is attractive for LCOS devices. Liquid crystal modelling tools [1] have been used to simulate the effects of rectangular and triangular shaped 'bumps' and 'dips' protruding from and extending into the LC's enclosing surfaces respectively. The director orientation and optical transmission of the LC pixels biased in this way are examined as a function of time during the switching cycle and spatially across the pixel to show that the combination provides controllable tilt bias

    The Genetic Basis of Phenotypic Heterogeneity in the Neuronal Ceroid Lipofuscinoses

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    The neuronal ceroid lipofuscinoses (NCLs) are a group of inherited neurodegenerative disorders that affect children and adults. They share some similar clinical features and the accumulation of autofluorescent storage material. Since the discovery of the first causative genes, more than 530 mutations have been identified across 13 genes in cases diagnosed with NCL. These genes encode a variety of proteins whose functions have not been fully defined; most are lysosomal enzymes, or transmembrane proteins of the lysosome or other organelles. Many mutations in these genes are associated with a typical NCL disease phenotype. However, increasing numbers of variant disease phenotypes are being described, affecting age of onset, severity or progression, and including some distinct clinical phenotypes. This data is collated by the NCL Mutation Database which allows analysis from many perspectives. This article will summarise and interpret current knowledge and understanding of their genetic basis and phenotypic heterogeneity

    Older adults' experiences and perceptions of digital technology: (dis)empowerment, wellbeing, and inclusion

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    As more and more of the business of society is transferred and conducted online, older adults frequently find themselves without the skills to participate effectively. This is frequently confounded by limited physical mobility and a decrease in their social network and contact. This paper examines the lived reality of that process and how digital technology could be used to enhance the life activity of older adults and their wellbeing by increasing their social network. Seventeen older adults (10 female, 7 male Mage = 71.67, SDage = 10.05) participated in two focus groups that each lasted approximately 90 min. Interpretative phenomenological analysis yielded two main themes: digital technology serving as a tool to disempower and empower. Findings support evidence of a digital divide and how that divide is evolving from the ideographic perspective of digitally-engaged older adults and for society. Discussions also surround barriers to digital technology use for older adults, the codification of digital technology use within society, and how older adults use digital technology in a facilitative and inclusive way to empower themselves and protect them from the negative effects of the digital divide

    Effect of the early-life nutritional environment on fecundity and fertility of mammals.

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    The early-life developmental environment is instrumental in shaping our overall adult health and well-being. Early-life diet and endocrine exposure may independently, or in concert with our genetic constitution, induce a pathophysiological process that amplifies with age and leads to premature morbidity and mortality. Recently, this has become known as 'programming' but is akin to 'maternal effects' described for many years in the biological sciences and is defined as any influence that acts during critical developmental windows to induce long-term changes in the organisms' phenotype. To date, such delayed maternal effects have largely been characterized in terms of susceptibility to cardiovascular or metabolic disease. Here, we review evidence from experimental animal species, non-human primates and man for an effect of the early-life nutritional environment on adult fecundity and fertility. In addition, using a database of pedigree sheep, we also specifically test the hypothesis that being born small for gestational age with or without post-natal growth acceleration directly programmes fertility. We conclude that there is a lack of compelling evidence to suggest pre-natal undernutrition may directly reduce adult fecundity and fertility, but may exert some effects secondarily via an increased incidence of 'metabolic syndrome'. Possible effects of being born relatively large on subsequent fecundity and fertility warrant further investigation

    Room temperature, continuous-wave coupled-cavity InAsP/InP photonic crystal laser with enhanced far-field emission directionality

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    We demonstrate room temperature, continuous-wave lasing with enhanced far field emission directionality in coupled-cavity photonic crystal lasers, made with InAsP/InP quantum well material. These surface-emitting lasers can have a very low effective threshold power of 14.6 µW, with a linewidth of 60 pm, and 40% of the surface emitted power concentrated within a small divergence angle of ±30°

    Room temperature, continuous-wave coupled-cavity InAsP/InP photonic crystal laser with enhanced far-field emission directionality

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    We demonstrate room temperature, continuous-wave lasing with enhanced far field emission directionality in coupled-cavity photonic crystal lasers, made with InAsP/InP quantum well material. These surface-emitting lasers can have a very low effective threshold power of 14.6 μW, with a linewidth of 60 pm, and 40 of the surface emitted power concentrated within a small divergence angle of ±30°. © 2011 American Institute of Physics.The authors would like to acknowledge support from the Defense Advanced Research Projects Agency under the Nanoscale Architecture for Coherent Hyperoptical Sources programme under Grant No. #W911NF-07-1-0277 and from the National Science Foundation through NSF CIAN ERC under Grant No. #EEC-0812072. J. G. would like to acknowledge support from NSF Research Experience for Teachers (RET) program through NSF CIAN ERC. P. A. P. would like to acknowledge financial support from Spanish MICINN and CAM through grants NANINPHO-QD (TEC2008- 06756-C03-01/03), CAM2010 Q&C Light (S2009ESP-1503) and Consolider-Ingenio 2010 QOIT (CSD2006-0019).Peer Reviewe
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