Aluminosilicate Proppants Based on Technogenic Raw Materials

В работе представлены результаты разработки технологии по лучения алюмосиликатных пропантов на основе техногенного сырья. В качестве сырьевых материалов использовали корундовую пыль, полученную при дроблении электроплавленного корунда. В качестве спекающей добавки — отсевы щебеночного производства (гранодиорит).The paper presents the results of developing a technology for producing aluminosilicate proppants based on technogenic raw materials. Corundum dust obtained by crushing electrofused corundum was used as a raw material. As a sintering additive is used screenings of crushed stone production (granodiorite)

Week 48 resistance analyses of the once-daily, single-tablet regimen darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) in adults living with HIV-1 from the Phase III Randomized AMBER and EMERALD Trials

Darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg is being investigated in two Phase III trials, AMBER (NCT02431247; treatment-naive adults) and EMERALD (NCT02269917; treatment-experienced, virologically suppressed adults). Week 48 AMBER and EMERALD resistance analyses are presented. Postbaseline samples for genotyping/phenotyping were analyzed from protocol-defined virologic failures (PDVFs) with viral load (VL) >= 400 copies/mL at failure/later time points. Post hoc analyses were deep sequencing in AMBER, and HIV-1 proviral DNA from baseline samples (VL = 3 thymidine analog-associated mutations (24% not fully susceptible to tenofovir) detected at screening. All achieved VL <50 copies/mL at week 48 or prior discontinuation. D/C/F/TAF has a high genetic barrier to resistance; no darunavir, primary PI, or tenofovir RAMs were observed through 48 weeks in AMBER and EMERALD. Only one postbaseline M184I/V RAM was observed in HIV-1 of an AMBER participant. In EMERALD, baseline archived RAMs to darunavir, emtricitabine, and tenofovir in participants with prior VF did not preclude virologic response

ECONOMIC EFFICIENCY OF THE IMPLEMENTATION OF THE PROGRAM OF CARDIOVASCULAR DISEASES MULTIFACTORIAL PREVENTION IN THE ORGANIZED COLLECTIVE OF TECHNICAL RESEARCH INSTITUTE

Aim. To estimate economic efficiency of a complex of resource-saving activities for cardiovascular diseases prevention at a workplace.Material and methods. The complex of activities including preventive examination and preventive intervention with their efficacy monitoring was performed in 523 people of a technical research institute staff. Preventive examination included evaluation procedures for cardiovascular diseases and their risk factors (89,5% of respondents). Preventive intervention based on risk factors modification was performed in intervention group. Control group included staff not participating in preventive consultation. Costs associated with cardiovascular diseases and risk factors (medical care consumption and temporary disability) and cost- efficiency analysis was performed.Results. High prevalence of arterial hypertension, metabolic and psychoemotional risk factors at workplace was found in preventive examination. Significant reduction in blood pressure (BP) and total cholesterol (TC) plasma level as well as a tendency to cardiovascular risk (CVR) decrease was reached due to preventive intervention. Costs associated with cardiovascular diseases and their risk factors in intervention group were lower than these in control group (168 584 and 489 500 rbl per 100 people yearly, respectively). Cost- efficiency analysis shown that costs of BP, TC plasma level and CVR reduction were moderate in intervention group. Costs were not efficient in control group.Conclusion. Implementation of cardiovascular diseases prevention at workplace is economically efficient both for society and for employer

CLINICAL AND ECONOMICAL RATIONALES OF CARDIOVASCULAR RISK EVALUATION AT WORKPLACE

Aim. To study clinical and economical rationales for cardiovascular risk evaluation at workplace (on example of the personnel of engineering research institute).Material and methods. Complex preventive screening with evaluation of arterial hypertension (HT) prevalence, cardiovascular risk level and requirement for risk factors correction is performed. Economical rationales for preventive screening (with estimation of the total costs, costs for one studied person and costs for revealing of one person needed in preventive actions) are also estimated.Results. Preventive screening in the organized collective found new HT cases (12,2%), high and very high cardiovascular risk (58,6%). The desire for risk factors correction is found in 13,0-59,0% of workers. The total costs for preventive screening of 468 persons were 174413 rubles in 3,5 months. Costs for examination of one worker were 561,7 rubles. Costs for detecting of one worker requiring preventive actions were from 635,6 to 3077,4 rublesConclusion. There are rationales for preventive screening of cardiovascular risk and desire to correct it at the workplace

Workplace programme of cardiovascular prevention: clinical effectiveness

Aim. To develop, test and evaluate the workplace (wp) programme of multifactorial prevention of cardiovascular disease (CVD). Material and methods. In a technical research institute, with 523 employees, a complex programme of CVD prevention was introduced, including preventive examination, preventive intervention, and clinical effectiveness monitoring. Preventive examination included complex assessment of CVD and CVD risk factors (RFs) (response rate 89,5 %). Preventive intervention, developed with consideration of CVD prevention demand, was performed in the intervention group (IG). The control group (CG) was formed according to “case-control” principle. In clinical effectiveness analysis, the dynamics of blood pressure (BP), total cholesterol (TC), psycho-emotional RFs, and SCORE-calculated CVD risk was assessed. Results. Preventive examination demonstrated high prevalence of arterial hypertension (AH), metabolic and psycho-emotional RFs at wp, together with high interest in RF correction. Preventive intervention resulted in a significant reduction in systolic BP (SBP) — by 9 mm Hg, in diastolic BP (DBP) — by 9,7 mm Hg, in TC — by 0,7 mmol/l, and also in SCORE-calculated CVD risk — from 3,8 % to 3,0 %. Conclusion. Complex CVD prevention at wp was associated with substantial beneficial effects within first 12 months

Еprosartan therapy effectiveness in arterial hypertension patients after stroke or transient ischemic attack

Aim. To study effectiveness, safety, and dynamics of cognitive function in eprosartan therapy among arterial hypertension (AH) patients after stroke (S) or transient ischemic attack (TIA), comparing to standard antihypertensive therapy. Material and methods. The study included 60 AH patients, who underwent S or TIA. All participants wee randomized to two equal groups. Mean age in Group I was 62,2±7,8 years, in Group II – 59,8±6,7 years; AH duration - 9,5±3,5 and 9,8±3,2 years, respectively. For 3 months, Group I received eprosartan (600 mg/d), as monotherapy or combined with hydrochlorthiazide, if target blood pressure (BP) level was not achieved. Group II received standard antihypertensive therapy. At 4 visits, BP, heart rate, body mass index were measured; medication tolerability were assessed. At the baseline and at the end of the study, electrocardiography, echocardiography, 24-hour BP monitoring (BPM), psychological testing with Beck and MMSE questionnaires were performed. Results. In 2 patients (6,7%) from control Group II, recurrent TIA episodes were registered. In both groups, a significant positive dynamics of all manually measured BP parameters was observed. At the end of the study, BP positive dynamics was more manifested in eprosartan group. Moreover, in Group I, depression and cognitive dysfunction levels substantially decreased. Conclusion. Eprosartan is an effective antihypertensive agent for AH treatment, with cerebroprotective effects in S and TIA patients, that could be used as monotherapy or in combination with a diuretic

Assessment of the need for cardiovascular risk factor prevention among organized populations of intellectual workers

One of the conditions for high-quality medical care, including medical prevention, is preliminary assessment of objective need for this type of medical service.Aim. То assess the need for medical prevention of cardiovascular risk factors (CVD RFs) in organized collectives of educational and research workers. То identifY preventive behavior models requiring different tactics for individual preventive programs.Material and methods. А survey was performed in two collectives of intellectual workers, to assess their need for CVD RF prevention and identify preventive behavior models as а basis for individual preventive programs.Results. Among the collectives exarnined, both CVD RF prevalence and unmet need for CVD RF coпection were high; the latter reached 70-80 % among all individuals with RFs.Conclusion. The indicators of preventive consulting need could Ье used for developing targeted preventive programs

Health-related quality of life, psychological status, and cardiovascular risk factors in intellectual workers

Aim. To study health-related quality of life (QoL), psychological status, and their associations with cardiovascular (CVD) risk factors (RFs) in education and science professionals, to specify the priorities of CVD prevention in organized collectives of intellectual workers.Material and methods. This preventive examination of two organized collectives of education and research workers assessed psycho-emotional status and health-related QoL. The examination was performed as a part of extended dispanserisation programme and included questionnaire survey, using such scales as HADS (anxiety and depression assessment), Reeder scale (stress assessment), and SF-36 (QoL).Results. The high prevalence of anxiety and depressive disorders pointed to increased CVD risk. Most traditional RFs positively correlated with depressive disorder severity. The two collectives examined were significantly different in terms of health-related QoL and some parameters of psycho-emotional stress. This could be partly explained by different workplace settings and social circumstances.Conclusion. In intellectual workers, CVD prevention should start with psycho-emotional and QoL correction, which could also improve the compliance to traditional RF correction