2,270 research outputs found
State of the body in disorders of diurnal physiological rhythms and long-term hypokinesia
In order to study the effects of hypokinesia and circadian rhythm restructuring on the morphological and functional status of the hypothalamo-hypophysic-adrenal system, young male Wistar rats were placed in small cages for varying periods. The animals were decapitated and preparations were made from sections of the brain and adrenals and numerous destructive changes were noted in the investigated regions of the brain, indicating that the condition of these areas is directly affected by disruption of established rhythms in physiological processes
Functional-morphological parallels of the hypothalamo-pituitary-adrenal system response reaction to long-term hypokinesia
The effect of 2 and 4 week hypokinesia regimens on the hypothalamo-pituitary-adrenal system (HPAS) was investigated in 110 inbred mice. Progressive exhaustion and pathological reorganization of the HPAS morphofunctional structures was revealed. On the basis of established facts of interlineary and interspecies differences in the HPAS response, it is suggested that the animal body response reaction to the long term effects of hypokinesia depends largely on its HPAS resistance and the values of this system's defensive adaptation potential
Currency and Financial Crises of the 1990s and 2000s
We survey three distinct types of financial crises which took place in the 1990s and the 2000s: 1) the credit implosion leading to severe banking crisis in Japan; 2) The foreign reserves’ meltdown triggered by foreign hot money flight from frothy economies with fixed exchange rate regimes of developing Asian economies, and 3) The 2008 worldwide debacle rooted in financial institutional opacity and reckless aggregate demand management, epicentered in the US, that spread almost instantaneously across the globe, mostly through international financial networks
Wire GEM detector
A wire GEM (WGEM) detector with a gas gap between meshes was constructed. The
detector provides the amplification 5x10E5 for the gas mixture of Ar +20% CO2
at atmospheric pressure. As compared with well-known GEM detectors produced by
perforation the plastic plate metalized on both sides the WGEM does not suffer
from breakdowns between its electrodes and the effect of accumulation of
charges on holes walls is absent. As a result the WGEM has high reliability and
stability.Comment: Presented at the RD51 Collaboration Meeting, CERN, November 2009,
submitted to the Prib. Tech. Expe
RETGEM with polyvinylchloride (PVC) electrodes
This paper presents a new design of the RETGEM (Resistive Electrode Thick
GEM) based on electrodes made of a polyvinylchloride material (PVC). Our device
can operate with gains of 10E5 as a conventional TGEM at low counting rates and
as RPC in the case of high counting rates without of the transit to the violent
sparks. The distinct feature of present RETGEM is the absent of the metal
coating and lithographic technology for manufacturing of the protective
dielectric rms. The electrodes from PVC permit to do the holes by a simple
drilling machine. Detectors on a RETGEM basis could be useful in many fields of
an application requiring a more cheap manufacturing and safe operation, for
example, in a large neutrino experiments, in TPC, RICH systems.Comment: Presented at the RD51 Collaboration Meeting, CERN, November 200
MARs Wars: heterogeneity and clustering of DNA-binding domains in the nuclear matrix
Aim. CO326 is a chicken nuclear scaffold/matrix attachment region (MAR) associated with the nuclear matrix in several types of chicken cells. It contains a binding site for a sequence-specific DNA-binding protein, F326. We have studied its interaction with the nuclear matrix. Methods. We have used an in vitro MAR assay with isolated matrices from chicken HD3 cells. Results. We have found that an oligonucleotide binding site for the F326 inhibits binding of the CO326 to the nuclear matrix. At the same time, the binding of heterologous MARs is enhanced. Conclusions. Taken together, these data suggest that there exist several classes of MARs and MAR-binding domains and that the MAR-binding proteins may be clustered in the nuclear matrix
Converging Measures and an Emergent Model: A Meta-Analysis of Human-Automation Trust Questionnaires
A significant challenge to measuring human-automation trust is the amount of
construct proliferation, models, and questionnaires with highly variable
validation. However, all agree that trust is a crucial element of technological
acceptance, continued usage, fluency, and teamwork. Herein, we synthesize a
consensus model for trust in human-automation interaction by performing a
meta-analysis of validated and reliable trust survey instruments. To accomplish
this objective, this work identifies the most frequently cited and
best-validated human-automation and human-robot trust questionnaires, as well
as the most well-established factors, which form the dimensions and antecedents
of such trust. To reduce both confusion and construct proliferation, we provide
a detailed mapping of terminology between questionnaires. Furthermore, we
perform a meta-analysis of the regression models that emerged from those
experiments which used multi-factorial survey instruments. Based on this
meta-analysis, we demonstrate a convergent experimentally validated model of
human-automation trust. This convergent model establishes an integrated
framework for future research. It identifies the current boundaries of trust
measurement and where further investigation is necessary. We close by
discussing choosing and designing an appropriate trust survey instrument. By
comparing, mapping, and analyzing well-constructed trust survey instruments, a
consensus structure of trust in human-automation interaction is identified.
Doing so discloses a more complete basis for measuring trust emerges that is
widely applicable. It integrates the academic idea of trust with the
colloquial, common-sense one. Given the increasingly recognized importance of
trust, especially in human-automation interaction, this work leaves us better
positioned to understand and measure it.Comment: 44 pages, 6 figures. Submitted, in part, to ACM Transactions on
Human-Robot Interaction (THRI
Signatures of motor susceptibility in the dynamics of a tracer particle in an active gel
We study a model for the motion of a tracer particle inside an active gel,
exposing the properties of the van Hove distribution of the particle
displacements. Active events of a typical force magnitude give rise to
non-Gaussian distributions, having exponential tails or side-peaks. The
side-peaks appear when the local bulk elasticity of the gel is large enough and
few active sources are dominant. We explain the regimes of the different
distributions, and study the structure of the peaks for active sources that are
susceptible to the elastic stress that they cause inside the gel. We show how
the van Hove distribution is altered by both the duty cycle of the active
sources and their susceptibility, and suggest it as a sensitive probe to
analyze microrheology data in active systems with restoring elastic forces.Comment: 4 pages, 4 figures and supplemental information (5 pages, 4 figures
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