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Coupling between gamma-band power and cerebral blood volume during recurrent acute neocortical seizures
Characterization of neural and hemodynamic biomarkers of epileptic activity that can be measured using non-invasive techniques is fundamental to the accurate identification of the epileptogenic zone (EZ) in the clinical setting. Recently, oscillations at gamma-band frequencies and above (>30 Hz) have been suggested to provide valuable localizing information of the EZ and track cortical activation associated with epileptogenic processes. Although a tight coupling between gamma-band activity and hemodynamic-based signals has been consistently demonstrated in non-pathological conditions, very little is known about whether such a relationship is maintained in epilepsy and the laminar etiology of these signals. Confirmation of this relationship may elucidate the underpinnings of perfusion-based signals in epilepsy and the potential value of localizing the EZ using hemodynamic correlates of pathological rhythms. Here, we use concurrent multi-depth electrophysiology and 2-dimensional optical imaging spectroscopy to examine the coupling between multi-band neural activity and cerebral blood volume (CBV) during recurrent acute focal neocortical seizures in the urethane-anesthetized rat. We show a powerful correlation between gamma-band power (25-90 Hz) and CBV across cortical laminae, in particular layer 5, and a close association between gamma measures and multi-unit activity (MUA). Our findings provide insights into the laminar electrophysiological basis of perfusion-based imaging signals in the epileptic state and may have implications for further research using non-invasive multi-modal techniques to localize epileptogenic tissue
Ventromedial Prefrontal and Anterior Cingulate Cortex Adopt Choice and Default Reference Frames during Sequential Multi-Alternative Choice
Although damage to the medial frontal cortex causes profound decision-making impairments, it has been difficult to pinpoint the relative
contributions of key anatomical subdivisions. Here we use function magnetic resonance imaging to examine the contributions of human
ventromedial prefrontal cortex (vmPFC) and dorsal anterior cingulate cortex (dACC) during sequential choices between multiple alternativesâ
two key features of choices made in ecological settings. By carefully constructing options whose current value at any given
decision was dissociable from their longer term value, we were able to examine choices in current and long-term frames of reference. We
present evidence showing that activity at choice and feedback in vmPFC and dACC was tied to the current choice and the best long-term
option, respectively. vmPFC, mid-cingulate, and posterior cingulate cortex encoded the relative value between the chosen and next best
option at each sequential decision, whereas dACC encoded the relative value of adapting choices from the option with the highest value in
the longer term. Furthermore, at feedback we identify temporally dissociable effects that predict repetition of the current choice and
adaptation away from the long-term best option in vmPFC and dACC, respectively. These functional dissociations at choice and feedback
suggest that sequential choices are subject to competing cortical mechanisms
Higher education, mature students and employment goals: policies and practices in the UK
This article considers recent policies of Higher Education in the UK, which are aimed at widening participation and meeting the needs of employers. The focus is on the growing population of part-time students, and the implications of policies for this group. The article takes a critical perspective on government policies, using data from a major study of mature part-time students, conducted in two specialist institutions in the UK, a London University college and a distance learning university. Findings from this study throw doubt on the feasibility of determining a priori what kind of study pathway is most conducive for the individual in terms of employment gains and opportunities for upward social mobility. In conclusion, doubts are raised as to whether policies such as those of the present UK government are likely to achieve its aims. Such policies are not unique to the UK, and lessons from this country are relevant to most of the developed world
Beam Profile Measurements and Simulations of the PETRA Laser-Wire
The Laser-wire will be an essential diagnostic tool at the International
Linear Collider. It uses a finely focussed laser beam to measure the transverse
profile of electron bunches by detecting the Compton-scattered photons (or
degraded electrons) downstream of where the laser beam intersects the electron
beam. Such a system has been installed at the PETRA storage ring at DESY, which
uses a piezo-driven mirror to scan the laser-light across the electron beam.
Lat- est results of experimental data taking are presented and compared to
detailed simulations using the Geant4 based program BDSIM.Comment: 3 pagesm 4 figures. Submitted as a conference paper for the Particle
Accelerator Conference 2005 (PAC05
A burst from the direction of UZ Fornacis with XMM-Newton
The XMM-Newton pointing towards the magnetic cataclysmic variable UZ For
finds the source to be a factor > 10^3 fainter than previous EXOSAT and ROSAT
observations. The source was not detected for the majority of a 22 ksec
exposure with the EPIC cameras, suggesting that the accretion rate either
decreased, or stopped altogether. However a 1.1 ksec burst was detected from UZ
For during the observation. Spectral fits favour optically thin, kT = 4.4 keV
thermal emission. Detection of the burst by the on-board Optical Monitor
indicates that this was most probably an accretion event. The 0.1-10 keV
luminosity of 2.1 x 10^30 erg/s is typical for accretion shock emission from
high state polars and would result from the potential energy release of ~ 10^16
g of gas. There is no significant soft excess due to reprocessing in the white
dwarf atmosphere.Comment: 7 pages, 2 postscript figures, ApJL, in pres
Comparison of stimulus-evoked cerebral hemodynamics in the awake mouse and under a novel anesthetic regime
Neural activity is closely followed by a localised change in cerebral blood flow, a process termed neurovascular coupling. These hemodynamic changes form the basis of contrast in functional magnetic resonance imaging (fMRI) and are used as a correlate for neural activity. Anesthesia is widely employed in animal fMRI and neurovascular studies, however anesthetics are known to profoundly affect neural and vascular physiology, particularly in mice. Therefore, we investigated the efficacy of a novel âmodularâ anesthesia that combined injectable (fentanyl-fluanisone/midazolam) and volatile (isoflurane) anesthetics in mice. To characterize sensory-evoked cortical hemodynamic responses, we used optical imaging spectroscopy to produce functional maps of changes in tissue oxygenation and blood volume in response to mechanical whisker stimulation. Following fine-tuning of the anesthetic regime, stimulation elicited large and robust hemodynamic responses in the somatosensory cortex, characterized by fast arterial activation, increases in total and oxygenated hemoglobin, and decreases in deoxygenated hemoglobin. Overall, the magnitude and speed of evoked hemodynamic responses under anesthesia resembled those in the awake state, indicating that the novel anesthetic combination significantly minimizes the impact of anesthesia. Our findings have broad implications for both neurovascular research and longitudinal fMRI studies that increasingly require the use of genetically engineered mice
Group selection models in prebiotic evolution
The evolution of enzyme production is studied analytically using ideas of the
group selection theory for the evolution of altruistic behavior. In particular,
we argue that the mathematical formulation of Wilson's structured deme model
({\it The Evolution of Populations and Communities}, Benjamin/Cumings, Menlo
Park, 1980) is a mean-field approach in which the actual environment that a
particular individual experiences is replaced by an {\it average} environment.
That formalism is further developed so as to avoid the mean-field approximation
and then applied to the problem of enzyme production in the prebiotic context,
where the enzyme producer molecules play the altruists role while the molecules
that benefit from the catalyst without paying its production cost play the
non-altruists role. The effects of synergism (i.e., division of labor) as well
as of mutations are also considered and the results of the equilibrium analysis
are summarized in phase diagrams showing the regions of the space of parameters
where the altruistic, non-altruistic and the coexistence regimes are stable. In
general, those regions are delimitated by discontinuous transition lines which
end at critical points.Comment: 22 pages, 10 figure
Broadband X-ray spectral analysis of the Seyfert 1 galaxy GRS 1734-292
We discuss the broadband X-ray spectrum of GRS 1734-292 obtained from
non-simultaneous XMM-Newton and NuSTAR observations, performed in 2009 and
2014, respectively. GRS1734-292 is a Seyfert 1 galaxy, located near the
Galactic plane at . The NuSTAR spectrum ( keV) is dominated by
a primary power-law continuum with and a high-energy
cutoff keV, one of the lowest measured by NuSTAR in a
Seyfert galaxy. Comptonization models show a temperature of the coronal plasma
of keV and an optical depth, assuming a slab
geometry, or a similar temperature and
assuming a spherical geometry. The 2009 XMM-Newton
spectrum is well described by a flatter intrinsic continuum
() and one absorption line due to Fe\textsc{XXV}
K produced by a warm absorber. Both data sets show a modest iron
K emission line at keV and the associated Compton reflection, due
to reprocessing from neutral circumnuclear material
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