Continuity of Plurisubharmonic Envelopes in C2\mathbb{C}^2

We show that in $\mathbb{C}^2$ if the set of strongly regular points are closed in the boundary of a smooth bounded pseudoconvex domain, then the domain is c-regular, that is, the plurisubharmonic upper envelopes of functions continuous up to the boundary are continuous on the closure of the domain. Using this result we prove that smooth bounded pseudoconvex Reinhardt domains in $\mathbb{C}^{2}$ are $c$-regular.Comment: 13 page

New CagL amino acid polymorphism patterns of helicobacter pylori in peptic ulcer and non-ulcer dyspepsia

Background and Objectives: Helicobacter pylori infection is associated with chronic gastritis, ulcers, and gastric cancer. The H. pylori Type 4 secretion system (T4SS) translocates the CagA protein into host cells and plays an essential role in initiating gastric carcinogenesis. The CagL protein is a component of the T4SS. CagL amino acid polymorphisms are correlated with clinical outcomes. We aimed to study the association between CagL amino acid polymorphisms and peptic ulcer disease (PUD) and non-ulcer dyspepsia (NUD). Materials and Methods: A total of 99 patients (PUD, 46; NUD, 53) were enrolled and screened for H. pylori by qPCR from antrum biopsy samples. The amino acid polymorphisms of CagL were analyzed using DNA sequencing, followed by the MAFFT sequence alignment program to match the amino acid sequences. Results: Antrum biopsy samples from 70 out of 99 (70.7%) patients were found to be H. pylori DNA-positive. A positive band for cagL was detected in 42 out of 70 samples (PUD, 23; NUD, 19), and following this, these 42 samples were sequenced. In total, 27 different polymorphisms were determined. We determined three CagL amino acid polymorphism combinations, which were determined to be associated with PUD and NUD. Pattern 1 (K35/N122/V134/T175/R194/E210) was only detected in PUD patient samples and was related to a 1.35-fold risk (p = 0.02). Patterns 2 (V41/I134) and 3 (V41/K122/A171/I174) were found only in NUD patient samples and were linked to a 1.26-fold increased risk (p = 0.03). Conclusions: We observed three new patterns associated with PUD and NUD. Pattern 1 is related to PUD, and the other two patterns (Patterns 2 and 3) are related to NUD. The patterns that we identified include the remote polymorphisms of the CagL protein, which is a new approach. These patterns may help to understand the course of H. pylori infection.Istanbul Aydin University Scientific Research Projects Uni

Effects of serum calcium levels on mortality and morbidity in patients with acute coronary syndrome

Akut Koroner Sendrom (AKS), risk faktörleri eşliğinde koroner arterlerde ateroskleroza bağlı olarak gelişen, miyokard iskemisi ya da nekrozu ile sonuçlanan klinik bir sendromdur. Kalsiyum kalp kasının kasılması, kalbin elektrofizyolojisi, trombosit adezyonu ve kanın pıhtılaşması dahil birçok kardiyovasküler olayda kritik bir rol almaktadır. Bu çalışmada, AKS tanısı konan ve Primer perkutan koroner girişim (PKG) yapılan hastalarda, serum düzeltilmiş Kalsiyum (dCa) seviyeleri ile mortalite ve morbidite (Konjestif Kalp yetmezliği, aritmi, yeni gelişen AKS) arasındaki ilişkinin değerlendirilmesi amaçlandı. Çalışmaya alınan 90 hasta 1,6 ve 12. aylarda takip edildi. Hastalar serum dCa seviyelerine göre; hipokalsemik (dCa10 mg/dl) olarak sınıflandırıldı. Çalışmamızda hiç hiperkalsemik hastamız yoktu ve 22 hastamız (%24,4) hipokalsemik, 68 hastamız (%75,6) normokalsemikti. Hastane içi mortalite oranı %15,5 (n=14) idi. Hastane içi mortalite; hipokalsemik grupta %22,7 (n=5), normokalsemik grupta %13,2 (n=9) idi ve her iki grup arasında anlamlı fark saptanmadı (p=0,332). Taburculuk sonrası 7-30. günler arasında, hipokalsemik grupta %11,7 (n=2) normokalsemik grupta %20,3 (n=12) hasta ex oldu. İlk yatışda ölçülen serum dCa düzeylerinin hastane içi mortalite için öngördürcü olmadığı (p>0,001) fakat taburculuk sonrası ilk bir ayda gerçekleşen mortalite üzerine anlamlı öngördürücü olduğu saptandı (p=0,038). Hastanın ilk geliş dCa değerindeki her bir birimlik standart sapmalık (SD) artış, mortalitede 7,4 kat artışa neden olduğu ve bu durumun, mortalitenin %20,8’ini açıkladığı gösterildi. Çalışmamızda dCa düzeyi için cutoff değeri 9, 04 mg/dl olarak saptandı (p<0,001), (sensitive %75, spesifite %67,7). Çalışmamızda serum dCa düzeyleri ile yeni gelişen kardiyovasküler olaylar arasında anlamlı bir ilişki ise saptanmadı. Sonuç olarak; AKS hastalarında ilk geliş serum dCa seviyeleri hastane içi mortalite üzerine anlamlı bir etkisinın olmadığı ancak taburculuk sonrası ilk bir ay içinde gelişen mortalite üzerine anlamlı bir öngördürücü olduğu ve dCa düzeyleri ile yeni gelişen kardiyovasküler olaylar arasında bir ilişki bulunmadığı ortaya kondu.Acute Coronary Syndrome (ACS) is a clinical syndrome,resulting in myocardial ischemia or necrosis that ocurs depends on coronary atherosclerosis with the risk factors . Calcium plays a critical role in many cardiovascular events, including contraction of the heart muscle, electrophysiology of the heart, platelet adhesion, and blood clotting. In this study, we aimed to evaluate the relationship between corrected serum calcium (cCa) levels and mortality and morbidity (congestive heart failure, arrhythmia, new ACS) in patients diagnosed with ACS who underwent primary percutaneous coronary intervention (PCI). 90 patients included in the study and followed up at 1st, 6th and 12th months. The patients were categorized as hypocalcemic (cCa 10 mg / dl) according to serum cCa levels. The present study, we had no hypercalcemic patients and 22 of them (24.4%) were hypocalcemic and 68 (75.6%) were normocalcemic. In-hospital mortality rate was 15.5% (n = 14). In-hospital mortality was 22.7% (n = 5) in the hypocalcemic group, and 13.2% (n = 9) in the normocalcemic group and no significant difference was found between the two groups (p = 0.332). Two of the patients (%11,7) in the hypocalcemic group and 12 patients (%20,3) in the normocalcemic group died between the day 7 and 30 after discharged. It was diagnosed that the serum cCa levels measured at the first hospitalization were not predictive for the in-hospital mortality (p> 0.001), but significant predictive of mortality in the first month after discharge (p = 0.038). It is indicated that standard deviation (SD) increase for each unit in the first-arrival cCa value of the patient caused a 7.4 times increase in mortality, which explained 20.8% of mortality. In our study, the cutoff value for cCa level was found to be 9,04 mg / dl (p <0.001), (sensitivity 75%, specificity 67.7%). In our study, no significant correlation was found between serum cCa levels and new cardiovascular events. Consequently, it was revealed that in the first-arrival serum cCa levels in ACS patients did not have a significant effect on in-hospital mortality but they were significant predictive of mortality developing within the first month after discharge and there was no relationship between cCa levels and new cardiovascular events