983 research outputs found
Entanglement dynamics for two harmonic oscillators coupled to independent environments
We study the entanglement evolution between two harmonic oscillators having
different free frequencies each leaking into an independent bath. We use an
exact solution valid in the weak coupling limit and in the short time
non-Markovian regime. The reservoirs are identical and characterized by an
Ohmic spectral distribution with Lorents-Drude cut-off. This work is an
extension of the case reported in [Phys. Rev. A 80, 062324 (2009)] where the
oscillators have the same free frequency.Comment: 8 pages, 3 figures, submitted to Physica Script
Dual contribution to amplification in the mammalian inner ear
The inner ear achieves a wide dynamic range of responsiveness by mechanically
amplifying weak sounds. The enormous mechanical gain reported for the mammalian
cochlea, which exceeds a factor of 4,000, poses a challenge for theory. Here we
show how such a large gain can result from an interaction between amplification
by low-gain hair bundles and a pressure wave: hair bundles can amplify both
their displacement per locally applied pressure and the pressure wave itself. A
recently proposed ratchet mechanism, in which hair-bundle forces do not feed
back on the pressure wave, delineates the two effects. Our analytical
calculations with a WKB approximation agree with numerical solutions.Comment: 4 pages, 4 figure
The Cochlear Tuning Curve
The tuning curve of the cochlea measures how large an input is required to
elicit a given output level as a function of the frequency. It is a fundamental
object of auditory theory, for it summarizes how to infer what a sound was on
the basis of the cochlear output. A simple model is presented showing that only
two elements are sufficient for establishing the cochlear tuning curve: a
broadly tuned traveling wave, moving unidirectionally from high to low
frequencies, and a set of mechanosensors poised at the threshold of an
oscillatory (Hopf) instability. These two components suffice to generate the
various frequency-response regimes which are needed for a cochlear tuning curve
with a high slope
Essential nonlinearities in hearing
Our hearing organ, the cochlea, evidently poises itself at a Hopf bifurcation
to maximize tuning and amplification. We show that in this condition several
effects are expected to be generic: compression of the dynamic range,
infinitely shrap tuning at zero input, and generation of combination tones.
These effects are "essentially" nonlinear in that they become more marked the
smaller the forcing: there is no audible sound soft enough not to evoke them.
All the well-documented nonlinear aspects of hearing therefore appear to be
consequences of the same underlying mechanism.Comment: 4 pages, 3 figure
Electronic phase separation near the superconductor-insulator transition of Nd1+xBa2−xCu3O7−δ thin films studied by an electric-field-induced doping effect
We report a detailed study of the transport properties of Nd(1+x)Ba(2-x)Cu(3)O(7-delta) thin films with doping changed by field effect. The data cover the whole superconducting to insulating transition and show remarkable Similarities with the effect of chemical doping in high critical temperature superconductors. The results suggest that the add-on of carriers is accompanied by an electronic phase separation, independent on the details of the doping mechanism
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Revealing nascent proteomics in signaling pathways and cell differentiation.
Regulation of gene expression at the level of protein synthesis is a crucial element in driving how the genetic landscape is expressed. However, we are still limited in technologies that can quantitatively capture the immediate proteomic changes that allow cells to respond to specific stimuli. Here, we present a method to capture and identify nascent proteomes in situ across different cell types without disturbing normal growth conditions, using O-propargyl-puromycin (OPP). Cell-permeable OPP rapidly labels nascent elongating polypeptides, which are subsequently conjugated to biotin-azide, using click chemistry, and captured with streptavidin beads, followed by digestion and analysis, using liquid chromatography-tandem mass spectrometry. Our technique of OPP-mediated identification (OPP-ID) allows detection of widespread proteomic changes within a short 2-hour pulse of OPP. We illustrate our technique by recapitulating alterations of proteomic networks induced by a potent mammalian target of rapamycin inhibitor, MLN128. In addition, by employing OPP-ID, we identify more than 2,100 proteins and uncover distinct protein networks underlying early erythroid progenitor and differentiation states not amenable to alternative approaches such as amino acid analog labeling. We present OPP-ID as a method to quantitatively identify nascent proteomes across an array of biological contexts while preserving the subtleties directing signaling in the native cellular environment
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A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS.
Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that direct chemical modifications at specific residues on other RNA molecules, primarily on ribosomal RNA (rRNA). SnoRNAs are altered in several cancers; however, their role in cell homeostasis as well as in cellular transformation remains poorly explored. Here, we show that specific subsets of snoRNAs are differentially regulated during the earliest cellular response to oncogenic RASG12V expression. We describe a novel function for one H/ACA snoRNA, SNORA24, which guides two pseudouridine modifications within the small ribosomal subunit, in RAS-induced senescence in vivo. We find that in mouse models, loss of Snora24 cooperates with RASG12V to promote the development of liver cancer that closely resembles human steatohepatitic hepatocellular carcinoma (HCC). From a clinical perspective, we further show that human HCCs with low SNORA24 expression display increased lipid content and are associated with poor patient survival. We next asked whether ribosomes lacking SNORA24-guided pseudouridine modifications on 18S rRNA have alterations in their biophysical properties. Single-molecule Fluorescence Resonance Energy Transfer (FRET) analyses revealed that these ribosomes exhibit perturbations in aminoacyl-transfer RNA (aa-tRNA) selection and altered pre-translocation ribosome complex dynamics. Furthermore, we find that HCC cells lacking SNORA24-guided pseudouridine modifications have increased translational miscoding and stop codon readthrough frequencies. These findings highlight a role for specific snoRNAs in safeguarding against oncogenic insult and demonstrate a functional link between H/ACA snoRNAs regulated by RAS and the biophysical properties of ribosomes in cancer
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