Return of the man-machine interface: violent interactions

This paper presents the design and evaluation of “the man-machine interface” a punchable interface designed to criticise and react against the values inherent in modern systems that tacitly favour one type of user (linguistically and technically gifted) and alienate another (physically gifted). We report a user study, where participants used the device to express their opinions before engaging in a group discussion about the implications of strength-based interactions. We draw connections between our own work and that of evolutionary biologists whose recent findings indicate the shape of the human hand is likely to have been partly evolved for the purpose of punching, and conclude by examining violent force as an appropriate means for expressing thoughts and feelings

Growth and Guidance: A Study of Neuron Morphology and How it is Modified by Fractal and Euclidean Electrodes In Vitro.

For well over a century, neuroscientists have been studying the inherent ties between neuronal morphology and functionality. Santiago Ramón y Cajal, in his work that ultimately awarded him a Nobel Prize in 1906, established that neurons function as the fundamental unit of the nervous system. Ramón y Cajal himself recognized the relationship between neuronal form and function by proposing the wiring economy principle, which states that the nervous system’s complex network of neurons is efficiently wired in a way that minimizes wiring length. The research within this dissertation works towards the goal of optimizing the design of the electrode-neuron interface of medical implants by building upon Ramón y Cajal’s foundational ideas and integrating them with the techniques of fractal analysis.The dissertation begins by addressing the question of how electrode geometry impacts the morphology of the networks of neurons and glia interfacing with the electrode. This was done by interacting dissociated mouse retinal cell cultures in vitro with vertically aligned carbon nanotube (VACNT) electrodes grown on a silicon dioxide (SiO2) substrate and patterned into Euclidean and fractal geometries. The VACNT-SiO2 material system was shown to perform exceptionally well at guiding neurons onto the VACNTs and glia onto the surrounding SiO2. Furthermore, the electrode geometries that performed the best at supporting a healthy network of neurons and glia were those that balanced providing a large VACNT electrode area with maintaining connectedness in the surrounding SiO2 surface and allowing it to interpenetrate the VACNT electrode. Following these in vitro experiments, three-dimensional models of pyramidal neurons from the CA1 region of the rat hippocampus were reconstructed using confocal microscopy. The fractal properties of the neurons and how these relate to their functionality were then analyzed. It was then demonstrated that the natural, fractal behavior of the neurons, though limited in its scaling range, was sufficient to provide the neurons with an optimal balance between connectivity and building and operating costs. The dissertation concludes by reviewing the results of these studies, providing directions for future work, and discussing the implications regarding electrode design. This dissertation includes previously published co-authored material

Disinhibited abuse of othered communities by second-screening audiences

Second-screening and live-tweeting alongside broadcast television generates new concerns with respect to online abuse. We present an investigation into the nature of Twitter-facilitated second-screening posts relating to Thelma's Gypsy Girls, one of a series of controversial documentary programmes portraying the Irish Traveller community that have recently been aired by the UK public-service television broadcaster Channel 4. Sentiment analysis highlighted the general negativity of these posts whilst a detailed thematic inquiry revealed the often abusive and aggressive messages aimed directly at the community and individuals portrayed in the broadcast material. We discuss why users might be susceptible to exhibiting these behaviours, and the implications for the broadcast industry, and social TV designers and developers

Neuron arbor geometry is sensitive to the limited-range fractal properties of their dendrites

12 pagesFractal geometry is a well-known model for capturing the multi-scaled complexity of many natural objects. By analyzing three-dimensional images of pyramidal neurons in the rat hippocampus CA1 region, we examine how the individual dendrites within the neuron arbor relate to the fractal properties of the arbor as a whole. We find that the dendrites reveal unexpectedly mild fractal characteristics quantified by a low fractal dimension. This is confirmed by comparing two fractal methods—a traditional “coastline” method and a novel method that examines the dendrites’ tortuosity across multiple scales. This comparison also allows the dendrites’ fractal geometry to be related to more traditional measures of their complexity. In contrast, the arbor’s fractal characteristics are quantified by a much higher fractal dimension. Employing distorted neuron models that modify the dendritic patterns, deviations from natural dendrite behavior are found to induce large systematic changes in the arbor’s structure and its connectivity within a neural network. We discuss how this sensitivity to dendrite fractality impacts neuron functionality in terms of balancing neuron connectivity with its operating costs. We also consider implications for applications focusing on deviations from natural behavior, including pathological conditions and investigations of neuron interactions with artificial surfaces in human implants

Physical Guidance of Cultured Retinal Neurons Using Zig-zag Surface Patterns

3 pagesThe use of physical cues to control and guide various types of cells in vitro, especially neurons and their processes, has been the focus of a large amount of research. The response of neuronal processes to artificial surfaces depends on a number of factors including the cell type, the surface chemistry of the material, and the surface’s topological features [1,2]. In this Opinion piece, we investigate the extent to which retinal neuronal processes can be made to follow straight lines patterned into a surface. We show they can follow lines with relatively shallow heights of 2 μm and be made to undergo directional changes as great as 50°. However, some processes leave the lines and assume a weaving trajectory as they grow into the surface’s unpatterned regions. Based on these findings, we propose that neuronal processes will follow lines more closely if their shapes mimic the fractal weave patterns of unrestricted neurons. In addition to exploring the fundamental behavior of neurons interacting with artificial surfaces, the results inform the design of bio-inspired electrodes for human implants.RPT is a Cottrell Scholar of the Research Council for Science Advancement. This research is supported by the WM Keck Foundation (RPT) and The Swedish Research Council (M.-T.P.: 2016-03757), Crown Princess Margareta’s Committee for the Blind, Stiftelse för Synskadade i fd Malmöhus Län and the Crafoordska Stiftelsen

Investigating Fractal Analysis as a Diagnostic Tool That Probes the Connectivity of Hippocampal Neurons

12 pagesMany of nature’s fractal objects benefit from the favorable functionality that results from their pattern repetition at multiple scales. Our recent research focused on the importance of fractal scaling in establishing connectivity between neurons. Fractal dimension DA of the neuron arbors was shown to relate to the optimization of competing functional constraints—the ability of dendrites to connect to other neurons versus the costs associated with building the dendrites. Here, we consider whether pathological states of neurons might affect this fractal optimization and if changes in DA might therefore be used as a diagnostic tool in parallel with traditional measures like Sholl analyses. We use confocal microscopy to obtain images of CA1 pyramidal neurons in the coronal plane of the dorsal rat hippocampus and construct 3-dimensional models of the dendritic arbors using Neurolucida software. We examine six rodent groups which vary in brain condition (whether they had lesions in the anterior thalamic nuclei, ATN) and experience (their housing environment and experience in a spatial task). Previously, we showed ATN lesions reduced spine density in hippocampal CA1 neurons, whereas enriched housing increased spine density in both ATN lesion and sham rats. Here, we investigate whether ATN lesions and experience also effect the complexity and connectivity of CA1 dendritic arbors. We show that sham rats exposed to enriched housing and spatial memory training exhibited higher complexity (as measured by DA) and connectivity compared to other groups. When we categorize the rodent groups into those with or without lesions, we find that both categories achieve an optimal balance of connectivity with respect to material cost. However, the DA value used to achieve this optimization does not change between these two categories, suggesting any morphological differences induced by the lesions are too small to influence the optimization process. Accordingly, we highlight considerations associated with applying our technique to publicly accessible repositories of neuron images with a broader range of pathological conditions

Aesthetics and Psychological Effects of Fractal Based Design

21 pagesHighly prevalent in nature, fractal patterns possess self-similar components that repeat at varying size scales. The perceptual experience of human-made environments can be impacted with inclusion of these natural patterns. Previous work has demonstrated consistent trends in preference for and complexity estimates of fractal patterns. However, limited information has been gathered on the impact of other visual judgments. Here we examine the aesthetic and perceptual experience of fractal ‘global-forest’ designs already installed in humanmade spaces and demonstrate how fractal pattern components are associated with positive psychological experiences that can be utilized to promote occupant wellbeing. These designs are composite fractal patterns consisting of individual fractal ‘tree-seeds’ which combine to create a ‘global fractal forest.’ The local ‘tree-seed’ patterns, global configuration of tree-seed locations, and overall resulting ‘global-forest’ patterns have fractal qualities. These designs span multiple mediums yet are all intended to lower occupant stress without detracting from the function and overall design of the space. In this series of studies, we first establish divergent relationships between various visual attributes, with pattern complexity, preference, and engagement ratings increasing with fractal complexity compared to ratings of refreshment and relaxation which stay the same or decrease with complexity. Subsequently, we determine that the local constituent fractal (‘treeseed’) patterns contribute to the perception of the overall fractal design, and address how to balance aesthetic and psychological effects (such as individual experiences of perceived engagement and relaxation) in fractal design installations. This set of studies demonstrates that fractal preference is driven by a balance between increased arousal (desire for engagement and complexity) and decreased tension (desire for relaxation or refreshment). Installations of these composite mid-high complexity ‘globalforest’ patterns consisting of ‘tree-seed’ components balance these contrasting needs, and can serve as a practical implementation of biophilic patterns in human-made environments to promote occupant wellbeing

Validating a Mobile Phone Application for the Everyday, Unobtrusive, Objective Measurement of Sleep

There is an identified need for objective, reliable, and scalable methods of measuring and recording sleep. Such methods must be designed for easy integration into people's lives in order to support both sleep therapy and everyday personal informatics. This paper describes the design and evaluation of a mobile phone application to record sleep, the design of which has substantive foundation in clinical sleep research. Two user studies were carried out which demonstrate that the application produces valid measurements of sleep quality and high levels of usability, whilst not seriously disturbing sleep or the sleep environment. These findings suggest that the app is suitable for both everyday sleep monitoring in a personal informatics context, and for integration into sleep interventions

Comparison of fractal and grid electrodes for studying the effects of spatial confinement on dissociated retinal neuronal and glial behavior

Understanding the impact of the geometry and material composition of electrodes on the survival and behavior of retinal cells is of importance for both fundamental cell studies and neuromodulation applications. We investigate how dissociated retinal cells from C57BL/6J mice interact with electrodes made of vertically-aligned carbon nanotubes grown on silicon dioxide substrates. We compare electrodes with different degrees of spatial confinement, specifically fractal and grid electrodes featuring connected and disconnected gaps between the electrodes, respectively. For both electrodes, we find that neuron processes predominantly accumulate on the electrode rather than the gap surfaces and that this behavior is strongest for the grid electrodes. However, the ‘closed’ character of the grid electrode gaps inhibits glia from covering the gap surfaces. This lack of glial coverage for the grids is expected to have long-term detrimental effects on neuronal survival and electrical activity. In contrast, the interconnected gaps within the fractal electrodes promote glial coverage. We describe the differing cell responses to the two electrodes and hypothesize that there is an optimal geometry that maximizes the positive response of both neurons and glia when interacting with electrodes

Controlled assembly of retinal cells on fractal and Euclidean electrodes

Controlled assembly of retinal cells on artificial surfaces is important for fundamental cell research and medical applications. We investigate fractal electrodes with branches of vertically- aligned carbon nanotubes and silicon dioxide gaps between the branches that form repeating patterns spanning from micro- to milli-meters, along with single-scaled Euclidean electrodes. Fluorescence and electron microscopy show neurons adhere in large numbers to branches while glial cells cover the gaps. This ensures neurons will be close to the electrodes' stimulating electric fields in applications. Furthermore, glia won't hinder neuronbranch interactions but will be sufficiently close for neurons to benefit from the glia's life-supporting functions. This cell 'herding' is adjusted using the fractal electrode's dimension and number of repeating levels. We explain how this tuning facilitates substantial glial coverage in the gaps which fuels neural networks with small-world structural characteristics. The large branch-gap interface then allows these networks to connect to the neuron-rich branches