Decrease in Protein Level in Final Finishing Phase of High Lean Gain Swine

In an attempt to increase the fat-to-lean ratio on modern lean pigs destined for a niche market, a high lean genetic line of finishing pigs capable of gaining more than 2.0 lbs per day (in latter growth stages over 100 lbs of body weight) were fed two diets with differing protein levels. Pigs consuming a lower protein diet ate less feed (1.46 lbs/day) and gained less (0.65 lbs/day). Backfat, loin muscle area, percent lean and lean gain per day were not different. Gender performance differences were as expected. Lowering the diet’s protein content below the pig’s requirement was not effective in creating change in fat-tolean ratio in the final finishing phase. The balance of all amino acids must be considered when attempting to reduce soybean meal content.

Performance Measures and Short-Termism: An Exploratory Study

We examine the relationship between performance measurement systems and short-termism. Hypotheses are tested on a sample of senior managers drawn from a major telecommunications company to determine the extent to which the diagnostic and interactive uses of financial and non-financial measures give rise to short-termism. We find no evidence to suggest that the use of financial measures, either diagnostically or interactively, leads to short-term behaviour. In contrast, we find a significant association between the use of non-financial measures and short-termism. Results suggest that the diagnostic use of non-financial measures leads managers to make inter-temporal trade-off choices that prioritise the short term to the detriment of the long term, while we find interactive use is negatively associated with short-termism. We find an imbalance in favour of the diagnostic use over the interactive use of non-financial performance measures is associated with short-termism. Overall, findings highlight the importance of considering the specific use of performance measures in determining the causes of short-termism

Determination of Optical Constants for Titan Aerosol-, and Exoplanet and Brown Dwarf Cloud Particle Analogs from the Visible to the Far Infrared

Here we present optical constants covering a broad wavelength range, from the visible to the far infrared, for Titan aerosol analogs produced in the Titan Haze Simulation (THS) experiment at Ames COSmIC facility, as well as other exoplanet-relevant materials

Examining a positive psychological role for performance measures

Emerging evidence suggests that management control systems may generate positive psychological effects, leading to higher levels of managerial performance. We extend this literature by examining the extent to which (1) financial vis-à-vis non-financial measures and (2) diagnostic vis-à-vis interactive utilisation of performance measures may be associated with decreasing role ambiguity and increasing psychological empowerment with performance as the ultimate outcome variable. We find that the interactive utilisation of non-financial performance measures can be particularly important for generating a positive psychological experience and (indirectly) increasing performance. Our study contributes further evidence of the psychologically beneficial role played by management control systems

Effect of Bt broccoli and resistant genotype of Plutella xylostella (Lepidoptera: Plutellidae) on development and host acceptance of the parasitoid Diadegma insulare (Hymenoptera: Ichneumonidae)

The ecological implications on biological control of insecticidal transgenic plants, which produce crystal (Cry) proteins from the soil bacterium Bacillus thuringiensis (Bt), remain a contentious issue and affect risk assessment decisions. In this study, we used a unique system of resistant insects, Bt plants and a parasitoid to critically evaluate this issue. The effects of broccoli type (normal or expressing Cry1Ac protein) and insect genotype (susceptible or Cry1Ac-resistant) of Plutella xylostella L. (Lepidoptera: Plutellidae) were examined for their effects on the development and host foraging behavior of the parasitoid, Diadegma insulare (Cresson) (Hymenoptera: Ichneumonidae) over two generations. Parasitism rate and development of D. insulare were not significantly different when different genotypes (Bt-resistant or susceptible) of insect host larvae fed on non-Bt broccoli plants. D. insulare could not discriminate between resistant and susceptible genotypes of P. xylostella, nor between Bt and normal broccoli plants with different genotypes of P. xylostella feeding on them. No D. insulare could emerge from Bt broccoli-fed susceptible and heterozygous P. xylostella larvae because these larvae were unable to survive on Bt broccoli. The parasitism rate, developmental period, pupal and adult weights of D. insulare that had developed on Bt broccoli-fed Cry1Ac-resistant P. xylostella larvae were not significantly different from those that developed on non-Bt broccoli-fed larvae. Female D. insulare emerged from Cry1Ac-resistant P. xylostella that fed on Bt plants could successfully parasitize P. xylostella larvae. The life parameters of the subsequent generation of D. insulare from P. xylostella reared on Bt broccoli were not significantly different from those from non-Bt broccoli. The Cry1Ac protein was detected in P. xylostella and in D. insulare when hosts fed on Bt broccoli. These results are the first to indicate that Cry1Ac did not harm the development or host acceptance of an important endoparasitoid after two generations of exposure. We suggest that using other Bt crops and resistant insect species would likely lead to similar conclusions about the safety of the presently used Bt proteins on parasitoid

Maximizing DDGS for Finishing Pigs in Bedded Hoop Barns: Trial One

Iowa’s ethanol industry continues to expand rapidly. A major coproduct of ethanol production is dried distillers grains with solubles (DDGS). Higher prices for corn and increasing supplies of DDGS have generated questions about feeding DDGS to market swine. The objective of this study was to evaluate various programs to maximize DDGS feeding to finishing pigs in bedded hoop barns. The work reported is the first of several trials planned

Definition of a platform continuous capture scale down model and link to scale-up for monoclonal antibody clinical manufacturing

Definition and scale-up of a batch chromatography process is based on a few main variables such as linear velocity, column loading, and bed height, which are scaled proportionally to column volume. Continuous chromatography consists of multiple columns with column loading and washes/elution/regeneration occurring simultaneously. The definition of a small scale method for continuous chromatography can be extremely complex due to the extensive number of method variables. Limited knowledge exists for development of a scale down and up strategy for continuous chromatography. This abstract should provide some insight into case studies on integration of continuous operations and scale-up, which is one of the themes of the integrated continuous biomanufacturing (ICB) conference. This presentation will describe a strategy for definition of a platform continuous capture scale down model and scale-up pathway. The platform continuous capture step utilizes periodic counter-current chromatography (PCC) for operation of affinity chromatography in a semi-continuous manner. A scale down model for the PCC step was defined and simplified to the following three ranges of harvested cell culture fluid (HCCF) titers: ≤ 2 g/L, 2.5-8 g/L, and 8.5-13 g/L. For each of the three titer ranges, the following variable setpoints are changed based on the specific HCCF titer range: step linear velocity, number of columns, column size, and ΔUV. After these setpoints are inputted into the algorithm, PCC method variables, such as sample loading flowrate, loop time, number of loops and cycles, throughput (g/L/hr), and time cycle, will populate to finish the method design. This PCC scale down model was utilized to scale-up to a bioreactor range of 500-2000L. Quality results showed a good correlation between scale down model and scale-up data. Additional parameters for the 2000L scale-up run included assessment of cleaning and drug substance stability. The cleaning results of the continuous chromatography skid showed passing bioburden, endotoxin, and conductivity. Drug substance stability was also maintained for a year, which was the study duration. This data set proves the PCC small scale model data is representative of the scale-up quality results. In addition, targets such as skid cleanability and DS stability met specifications, which supports the scale-up package for implementation of a platform continuous capture step into a purification process for clinical mAb manufacturing

Maximizing DDGS for Finishing Pigs in Bedded Hoop Barns

Higher prices for corn and increasing supplies of DDGS have generated questions about feeding DDGS to market swine. The objective of this study was to evaluate various programs to maximize DDGS feeding to finishing pigs in bedded hoop barns. The project was conducted during 2008 and 2009 at the ISU Western Research Farm, Castana, IA. The pens were in small hoop barns with two pens per barn. Each pen was assigned to one of three dietary treatments— continuous 20% DDGS (Cont), a step-up program from 0% to 30% DDGS (Step), and a high DDGS program that rapidly got pigs to 30% DDGS (High). All treatments were fed a 20% DDGS diet for the last phase of the trial. There were 4 dietary phases in the 98-day trial. Phase 1 and 4 were each 21d. Phase 2 and 3 were each 28d. The diets were pelletted and fed ad libitum. Within each phase, the diets were formulated to be equal in apparent digestible amino acids—lysine, threonine, and tryptophan. The pigs consumed the diets readily with no apparent problems making the transition among the diets. Feed intake (ADFI), growth (ADG), and feed per liveweight gain (F/G) did not differ among treatments (P \u3e 0.05). No major differences were noted in backfat thickness (BF) and loin muscle area (LMA) (P \u3e 0.05). Also, based on the means of fatty acid saturation, iodine values, and belly flop scores of selected pigs in trial (one, two or three), the differences in unsaturation percentages, iodine value and belly flop scores between treatments were minor. On average, a pig fed the continuous program consumed 119 lb of DDGS or 20% of the total feed over the 98-day feeding trial (from 54 to 274 lb). A pig fed the Step-up program consumed 106 lb of DDGS or 17% of the total feed. A pig fed the High program consumed 162 lb of DDGS or 26% of the total feed. This work suggests that diets and feeding programs can be designed to increase DDGS usage by market swine without negatively affecting pig performance. Also formulating diets on apparent digestible amino acid content may be advantageous when using DDGS on swine diets. The pelleted diets worked well with no problems in feed flow or fines separation

Feeding DDGS to Finishing Pigsin Deep-Bedded Hoop Barns

The ethanol industry in Iowa has rapidly expanded in the last several years. A major coproduct of ethanol production is dried distillers grains with solubles(DDGS). Higher prices for corn and ample supplies of DDGS has generated interest in feeding DDGS to finishing pigs. Challenges in feeding DDGS supplemented diets to finishing swine include problems of feed flowability in bulk bins and feeders, reduced feed intake, and softer, oilier fat in pork carcasses. Pelleted diets have improved flowability and may stimulate feed intake, but thus far no studies have examined feeding DDGS-supplemented dietsin pelletted form to pigs. The objective of this study was to evaluate pelletted DDGS-based diets fed to finishing pigs

Modeling the Integration of Parasitoid, Insecticide, and Transgenic Insecticidal Crop for the Long-Term Control of an Insect Pest

The tools of insect pest management include host plant resistance, biological control, and insecticides and how they are integrated will influence the durability of each. We created a detailed model of the population dynamics and population genetics of the diamondback moth, Plutella xylostella L., and its parasitoid, Diadegma insulare (Cresson), to study long-term pest management in broccoli Brassica oleracea L. Given this pest's history of evolving resistance to various toxins, we also evaluated the evolution of resistance to transgenic insecticidal Bt broccoli (expressing Cry1Ac) and two types of insecticides. Simulations demonstrated that parasitism provided the most reliable, long-term control of P. xylostella populations. Use of Bt broccoli with a 10% insecticide-free refuge did not reduce the long-term contribution of parasitism to pest control. Small refuges within Bt broccoli fields can delay evolution of resistance >30 generations if resistance alleles are rare in the pest population. However, the effectiveness of these refuges can be compromised by insecticide use. Rainfall mortality during the pest's egg and neonate stages significantly influences pest control but especially resistance management. Our model results support the idea that Bt crops and biological control can be integrated in integrated pest management and actually synergistically support each other. However, the planting and maintenance of toxin-free refuges are critical to this integratio