BioNanoAdhesion: atomic force microscopy study of the electrostatic properties of pyridine-and imidazole-based polycationic surfaces

Self-assembled monolayers of pyridine- and imidazole-based disulfides are currently being produced on low roughness gold surfaces. The electrostatic interaction between these surfaces and an atomic force microscope cantilever, modified with a silica microparticle, will subsequently be investigated as a function of environmental pH. The results can be used towards the development of improved nanoparticulate non-viral gene delivery vectors