Effects of four Fusarium toxins (fumonisin B(1), alpha-zearalenol, nivalenol and deoxynivalenol) on porcine whole-blood cellular proliferation.

The in vitro effects of four Fusarium toxins, fumonisin B1 (FB1), a-zearalenol (a-ZEA), nivalenol (NIV) and deoxynivalenol (DON), on mitogen-induced cell proliferation were determined in swine whole-blood cultures. Considering the lack of sufficient toxicological data both on single and in combination effects, in vitro studies may contribute to risk assessment of these toxins. Incubation with increasing concentrations of FB1 did not produce any consequence on proliferation; in contrast a-ZEA, NIV and DON showed an inhibitory effect. Dose–response curves for each mycotoxin were generated. NIV was found to be the most potent toxin followed by DON and a-ZEA. The effects of both FB1 þ a-ZEA and NIVþ DON mixtures were also analysed to investigate possible interactions. The results indicated that combination of FB1þ a-ZEA produces a synergistic inhibition of porcine cell proliferation; whereas there is no interaction between DON and NIV on porcine wholeblood proliferation, at tested concentrations

A multilingual grammar for 'The International Style', and its hybrid grammar

This paper describes the proposal and results of a multilingual shape grammar to describe the designs of three architects, precursors of the 'International Style'. A shape grammar is a generative process that allows the recreation of designs that follow a language. Grammars are useful mechanisms to describe patterns and generative processes that can be used for analysis or design exploration. Most grammars represent one language. This study focuses on three independent languages ​​within the same movement. The proposed grammar is parametric and allows the independent recreation of each independent design. Its difficult application can be linked to the difficult evaluation process. This research proposes a quantitative and a qualitative method of grammar evaluation, using respectively Principal Components Analysis (PCA) and user questionnaires. The results are then discussed and assessed using hybrids that fall in between languages ​​and help delineate parametric spaces

Ionization Mechanisms in Jet-Dominated Seyferts: A Detailed Case Study

For the past 10 years there has been an active debate over whether fast shocks play an important role in ionizing emission line regions in Seyfert galaxies. To investigate this claim, we have studied the Seyfert 2 galaxy Mkn 78, using HST UV/optical images and spectroscopy. Since Mkn 78 provides the archetypal jet-driven bipolar velocity field, if shocks are important anywhere they should be important in this object. Having mapped the emission line fluxes and velocity field, we first compare the ionization conditions to standard photoionization and shock models. We find coherent variations of ionization consistent with photoionization model sequences which combine optically thick and thin gas, but are inconsistent with either autoionizing shock models or photoionization models of just optically thick gas. Furthermore, we find absolutely no link between the ionization of the gas and its kinematic state, while we do find a simple decline of ionization degree with radius. We feel this object provides the strongest case to date against the importance of shock related ionization in Seyferts.Comment: 4 pages, 1 figure, to appear in the proceedings of IAU Symposium 222 "The Interplay among Black Holes, Stars and ISM in Galactic Nuclei", T. Storchi Bergmann, L.C. Ho & H.R. Schmitt, ed

The Nuclear Outflow in NGC 2110

We present a HST/STIS spectroscopic and optical/radio imaging study of the Seyfert NGC 2110 aiming to measure the dynamics and understand the nature of the nuclear outflow in the galaxy. Previous HST studies have revealed the presence of a linear structure in the Narrow-Line Region (NLR) aligned with the radio jet. We show that this structure is strongly accelerated, probably by the jet, but is unlikely to be entrained in the jet flow. The ionisation properties of this structure are consistent with photoionisation of dusty, dense gas by the active nucleus. We present a plausible geometrical model for the NLR, bringing together various components of the nuclear environment of the galaxy. We highlight the importance of the circum-nuclear disc in determining the appearance of the emission line gas and the morphology of the jet. From the dynamics of the emission line gas, we place constraints on the accelerating mechanism of the outflow and discuss the relative importance of radio source synchrotron pressure, radio jet ram pressure and nuclear radiation pressure in accelerating the gas. While all three mechanisms can account for the energetics of the emission line gas, gravitational arguments support radio jet ram pressure as the most likely source of the outflow.Comment: 15 pages, 7 figures; accepted to MNRA

Community Partnerships for Cultural Participation: Concepts, Prospects, and Challenges

Evaluates the first year of the Wallace Foundation's Community Partnerships for Cultural Participation Initiative, which funded nine community foundations working to increase participation in the arts and culture in their communities

Theory of integer quantum Hall polaritons in graphene

We present a theory of the cavity quantum electrodynamics of the graphene cyclotron resonance. By employing a canonical transformation, we derive an effective Hamiltonian for the system comprised of two neighboring Landau levels dressed by the cavity electromagnetic field (integer quantum Hall polaritons). This generalized Dicke Hamiltonian, which contains terms that are quadratic in the electromagnetic field and respects gauge invariance, is then used to calculate thermodynamic properties of the quantum Hall polariton system. Finally, we demonstrate that the generalized Dicke description fails when the graphene sheet is heavily doped, i.e. when the Landau level spectrum of 2D massless Dirac fermions is approximately harmonic. In this case we `integrate out' the Landau levels in valence band and obtain an effective Hamiltonian for the entire stack of Landau levels in conduction band, as dressed by strong light-matter interactions.Comment: 20 pages, 7 figure

Robust optimal quantum gates for Josephson charge qubits

Quantum optimal control theory allows to design accurate quantum gates. We employ it to design high-fidelity two-bit gates for Josephson charge qubits in the presence of both leakage and noise. Our protocol considerably increases the fidelity of the gate and, more important, it is quite robust in the disruptive presence of 1/f noise. The improvement in the gate performances discussed in this work (errors of the order of 10^{-3}-10^{-4} in realistic cases) allows to cross the fault tolerance threshold.Comment: 4 pages, 4 figure