Moral Injury:A Framework for Understanding Conflict-Related Sexual Violence Against Men

Studies on conflict-related sexual violence (CRSV) emphasize the need for the integration of a victim-centered lens into Feminist International Relations (IR) frameworks on sexual violence victimization in conflict or war. However, our understanding of the perpetrator-centered lens is limited. Drawing from ethnographic accounts of Nigerian security agents, male victims of CRSV, and aid workers, we analyze moral injury as a framework for discussing CRSV. In Nigeria, counterterrorism operations can lead to morally detrimental circumstances due to the government’s poor management of counterterrorism operations, resulting in the loss of lives and subsequent feelings of betrayal, anger, and guilt by security agents. Some security agents often display these emotions through violent acts to others, such as CRSV against men and boys suspected of terrorism, thereby exacerbating moral injury. The guilt-based moral injury arises when security agents witness CRSV against men and boys by colleagues and fail to seek justice for victims, as this contradicts social and institutional norms. Our article broadens the concept of moral injury by elucidating its significance to CRSV. In doing so, it advances the concept’s disciplinary focus on psychology to IR or international security—counterterrorism and CRSV—for conceptual sophistication and interdisciplinary exchange of thoughts. This article offers valuable insights into trauma-informed international humanitarian interventions for security agents and victims

Moral Injury:A Framework for Understanding Conflict-Related Sexual Violence Against Men

Studies on conflict-related sexual violence (CRSV) emphasize the need for the integration of a victim-centered lens into Feminist International Relations (IR) frameworks on sexual violence victimization in conflict or war. However, our understanding of the perpetrator-centered lens is limited. Drawing from ethnographic accounts of Nigerian security agents, male victims of CRSV, and aid workers, we analyze moral injury as a framework for discussing CRSV. In Nigeria, counterterrorism operations can lead to morally detrimental circumstances due to the government’s poor management of counterterrorism operations, resulting in the loss of lives and subsequent feelings of betrayal, anger, and guilt by security agents. Some security agents often display these emotions through violent acts to others, such as CRSV against men and boys suspected of terrorism, thereby exacerbating moral injury. The guilt-based moral injury arises when security agents witness CRSV against men and boys by colleagues and fail to seek justice for victims, as this contradicts social and institutional norms. Our article broadens the concept of moral injury by elucidating its significance to CRSV. In doing so, it advances the concept’s disciplinary focus on psychology to IR or international security—counterterrorism and CRSV—for conceptual sophistication and interdisciplinary exchange of thoughts. This article offers valuable insights into trauma-informed international humanitarian interventions for security agents and victims

Electrostatic hot spot on DNA-binding domains mediates phosphate desolvation and the pre-organization of specificity determinant side chains

A major obstacle towards elucidating the molecular basis of transcriptional regulation is the lack of a detailed understanding of the interplay between non-specific and specific protein–DNA interactions. Based on molecular dynamics simulations of C2H2 zinc fingers (ZFs) and engrailed homeodomain transcription factors (TFs), we show that each of the studied DNA-binding domains has a set of highly constrained side chains in preset configurations ready to form hydrogen bonds with the DNA backbone. Interestingly, those domains that bury their recognition helix into the major groove are found to have an electrostatic hot spot for Cl− ions located on the same binding cavity as the most buried DNA phosphate. The spot is characterized by three protein hydrogen bond donors, often including two basic side chains. If bound, Cl− ions, likely mimicking phosphates, steer side chains that end up forming specific contacts with bases into bound-like conformations. These findings are consistent with a multi-step DNA-binding mechanism in which a pre-organized set of TF side chains assist in the desolvation of phosphates into well defined sites, prompting the re-organization of specificity determining side chains into conformations suitable for the recognition of their cognate sequence

Effects of a balanced translocation between chromosomes 1 and 11 disrupting the DISC1 locus on white matter integrity

Objective Individuals carrying rare, but biologically informative genetic variants provide a unique opportunity to model major mental illness and inform understanding of disease mechanisms. The rarity of such variations means that their study involves small group numbers, however they are amongst the strongest known genetic risk factors for major mental illness and are likely to have large neural effects. DISC1 (Disrupted in Schizophrenia 1) is a gene containing one such risk variant, identified in a single Scottish family through its disruption by a balanced translocation of chromosomes 1 and 11; t(1;11) (q42.1;q14.3). Method Within the original pedigree, we examined the effects of the t(1;11) translocation on white matter integrity, measured by fractional anisotropy (FA). This included family members with (n = 7) and without (n = 13) the translocation, along with a clinical control sample of patients with psychosis (n = 34), and a group of healthy controls (n = 33). Results We report decreased white matter integrity in five clusters in the genu of the corpus callosum, the right inferior fronto-occipital fasciculus, acoustic radiation and fornix. Analysis of the mixed psychosis group also demonstrated decreased white matter integrity in the above regions. FA values within the corpus callosum correlated significantly with positive psychotic symptom severity. Conclusions We demonstrate that the t(1;11) translocation is associated with reduced white matter integrity in frontal commissural and association fibre tracts. These findings overlap with those shown in affected patients with psychosis and in DISC1 animal models and highlight the value of rare but biologically informative mutations in modeling psychosis