(Chloromethyl)pentacarbonylmanganese(I): a crystal structure with a non-crystallographic centre of symmetry

There are two molecules in the asymmetric unit of the P2₁/c unit cell of ClCH₂Mn(CO)₅, the first halomethyl complex of manganese to be structurally determined. The molecules are crystallographically independent, despite an apparent local centre of symmetry. The average bond parameters include Mn–Calkyl 2.128(8) Å, C–Cl 1.811(8) Å and Mn–C–Cl 116.4(4)

Platelet Lysate to Promote Angiogenic Cell Therapies

Cellular therapies for patients with ischemic muscle have been limited by poor cell retention and survivability. Platelets are a robust source of growth factors and structural proteins, and extracts from this peripheral blood component may be manipulated to improve both cell retention and survivability in percutaneous delivery methods. Human platelet lysate is generated from pooled human platelets and contains a growth factor milieu that promotes robust human mesenchymal stem cell (MSC) proliferation without risk of xenogenic contamination. As such, platelet lysate is a practical alternative to animal serum for MSC culture and, with minor adjustments to the production process, can also be used as a scaffold for cell delivery. Human platelet lysate is a promising substrate that can provide nutritive delivery both in vitro and during cell implantation, potentially improving retention and survivability of MSCs that may improve angiogenic function for cell therapy in treatment of ischemic tissues

Primary Squamous Cell Carcinoma of the Urinary Bladder Presenting as Peritoneal Carcinomatosis

We report an unusual case of a 78-year-old Caucasian female, who presented with peritoneal carcinomatosis and hypercalcemia, and was found to have a rapidly progressive primary squamous cell carcinoma of the urinary bladder. Squamous cell bladder carcinoma is a rare malignancy in the United States, accounting for just 1–3% of bladder tumors. Interestingly our patient lacked the established risk factors, including exposure to the parasite Schistosoma haematobium, recurrent urinary tract infections, bladder calculi, radiation exposure, chronic indwelling catheter, neurogenic bladder, or tobacco abuse. Although hypercalcemia has been rarely described, an initial presentation of peritioneal carcinomatosis has not been previously reported

Building research capacity for evidence-informed tobacco control in Canada: a case description

Tobacco use remains the leading cause of death and disability in Canada. Insufficient research capacity can inhibit evidence-informed decision making for tobacco control. This paper outlines a Canadian project to build research capacity, defined as a community's ability to produce research that adequately informs practice, policy, and future research in a timely, practical manner. A key component is that individuals and teams within the community must mutually engage around common, collectively negotiated goals to address specific practices, policies or programs of research. An organizing framework, a set of activities to build strategic recruitment, productivity tools, and procedures for enhancing social capital are described. Actions are intended to facilitate better alignment between research and the priorities of policy developers and service providers, enhance the external validity of the work performed, and reduce the time required to inform policy and practice

Spatial dependency between task positive and task negative networks

Functional neuroimaging reveals both relative increases (task-positive) and decreases (task-negative) in neural activation with many tasks. There are strong spatial similarities between many frequently reported task-negative brain networks, which are often termed the default mode network. The default mode network is typically assumed to be a spatially-fixed network; however, when defined by task-induced deactivation, its spatial distribution it varies depending on what specific task is being performed. Many studies have revealed a strong temporal relationship between task-positive and task-negative networks that are important for efficient cognitive functioning and here. Here, using data from four different cognitive tasks taken from two independent datasets, we test the hypothesis that there is also a fundamental spatial relationship between them. Specifically, it is hypothesized that the distance between task positive and negative-voxels is preserved despite different spatial patterns of activation and deactivation being evoked by different cognitive tasks. Here, we show that there is lower variability in the distance between task-positive and task-negative voxels across four different sensory, motor and cognitive tasks than would be expected by chance - implying that deactivation patterns are spatially dependent on activation patterns (and vice versa) and that both are modulated by specific task demands. We propose that this spatial relationship may be the macroscopic analogue of microscopic neuronal organization reported in sensory cortical systems, and we speculate why this spatial organization may be important for efficient sensorimotor and cognitive functioning.Comment: 16 pages, 4 figure

Mining Public Domain Data to Develop Selective DYRK1A Inhibitors

Kinases represent one of the most intensively pursued groups of targets in modern-day drug discovery. Often it is desirable to achieve selective inhibition of the kinase of interest over the remaining ∼500 kinases in the human kinome. This is especially true when inhibitors are intended to be used to study the biology of the target of interest. We present a pipeline of open-source software that analyzes public domain data to repurpose compounds that have been used in previous kinase inhibitor development projects. We define the dual-specificity tyrosine-regulated kinase 1A (DYRK1A) as the kinase of interest, and by addition of a single methyl group to the chosen starting point we remove glycogen synthase kinase β (GSK3β) and cyclin-dependent kinase (CDK) inhibition. Thus, in an efficient manner we repurpose a GSK3β/CDK chemotype to deliver 8b, a highly selective DYRK1A inhibitor

Resolved Mid-IR Emission in the Narrow Line Region of NGC 4151

We present subarcsecond resolution mid infrared images of NGC 4151 at 10.8 micron and 18.2 micron. These images were taken with the University of Florida mid-IR camera/spectrometer OSCIR at the Gemini North 8-m telescope. We resolve emission at both 10.8 micron and 18.2 micron extending ~ 3.5" across at a P.A. of ~ 60 degrees. This coincides with the the narrow line region of NGC 4151 as observed in [OIII] by the Hubble Space Telescope. The most likely explanation for this extended mid-IR emission is dust in the narrow line region heated by a central engine. We find no extended emission associated with the proposed torus and place an upper limit on its mid-IR size of less than or equal to ~ 35 pc.Comment: accepted for publication in the Astrophysical Journal, 19 pages including 5 figure

AzTEC millimeter survey of the COSMOS field - III. Source catalog over 0.72 sq. deg. and plausible boosting by large-scale structure

We present a 0.72 sq. deg. contiguous 1.1mm survey in the central area of the COSMOS field carried out to a 1sigma ~ 1.26 mJy/beam depth with the AzTEC camera mounted on the 10m Atacama Submillimeter Telescope Experiment (ASTE). We have uncovered 189 candidate sources at a signal-to-noise ratio S/N >= 3.5, out of which 129, with S/N >= 4, can be considered to have little chance of being spurious (< 2 per cent). We present the number counts derived with this survey, which show a significant excess of sources when compared to the number counts derived from the ~0.5 sq. deg. area sampled at similar depths in the Scuba HAlf Degree Extragalactic Survey (SHADES, Austermann et al. 2010). They are, however, consistent with those derived from fields that were considered too small to characterize the overall blank-field population. We identify differences to be more significant in the S > 5 mJy regime, and demonstrate that these excesses in number counts are related to the areas where galaxies at redshifts z < 1.1 are more densely clustered. The positions of optical-IR galaxies in the redshift interval 0.6 < z < 0.75 are the ones that show the strongest correlation with the positions of the 1.1mm bright population (S > 5 mJy), a result which does not depend exclusively on the presence of rich clusters within the survey sampled area. The most likely explanation for the observed excess in number counts at 1.1mm is galaxy-galaxy and galaxy-group lensing at moderate amplification levels, that increases in amplitude as one samples larger and larger flux densities. This effect should also be detectable in other high redshift populations.Comment: 21 pages, 17 figures, accepted for publication in MNRA