18 research outputs found
Data for: Assessing the efficacy and ecology of biocontrol and biomanipulation for managing invasive pest fish
This is the data for the paper 'Assessing the efficacy and ecology of biocontrol and biomanipulation for managing invasive pest fish' in Journal of Applied Ecolog
Enantioselective Total Synthesis of the Marine Macrolides Salarins A and C
Here we report the first total synthesis of the marine
macrolide
salarin C, a potent anticancer agent, and demonstrate the biomimetic
oxidation–Wasserman rearrangement to access salarin A. This
synthesis relies on L-proline catalysis to install a chlorohydrin
function that masks the sensitive C16–C17 epoxide and potentially
mimics the biosynthesis of these compounds where a related chlorohydrin
may yield both THF- and epoxide-containing salarins. Additional and
key features of the synthesis include (i) macrocycle formation via
ring-closing metathesis, (ii) macrocyclic substrate-controlled epoxidation
of the C12–C13 allylic alcohol, and (iii) a late-stage Julia–Kocienski
olefination to install the side chain. Importantly, this work provides
a platform for the synthesis of other salarins and analogues of these
potentially important anticancer natural products
Enantioselective Total Synthesis of the Marine Macrolides Salarins A and C
Here we report the first total synthesis of the marine
macrolide
salarin C, a potent anticancer agent, and demonstrate the biomimetic
oxidation–Wasserman rearrangement to access salarin A. This
synthesis relies on L-proline catalysis to install a chlorohydrin
function that masks the sensitive C16–C17 epoxide and potentially
mimics the biosynthesis of these compounds where a related chlorohydrin
may yield both THF- and epoxide-containing salarins. Additional and
key features of the synthesis include (i) macrocycle formation via
ring-closing metathesis, (ii) macrocyclic substrate-controlled epoxidation
of the C12–C13 allylic alcohol, and (iii) a late-stage Julia–Kocienski
olefination to install the side chain. Importantly, this work provides
a platform for the synthesis of other salarins and analogues of these
potentially important anticancer natural products
Total Synthesis of the Cytotoxic Anhydrophytosphingosine Pachastrissamine (Jaspine B)
A short, 8-step synthesis of the
marine natural product pachastrissamine
has been developed that relies on a diastereoselective aldol reaction
between a suitably protected hydantoin and an optically enriched α-chloroaldehyde.
This synthetic route provides new opportunities for exploring structure
activity relationships within this family of natural products
A Tandem Organocatalytic α‑Chlorination–Aldol Reaction That Proceeds with Dynamic Kinetic Resolution: A Powerful Tool for Carbohydrate Synthesis
A tandem, proline-catalyzed α-chlorination/aldol reaction is described that involves a dynamic kinetic resolution of α-chloroaldehyde intermediates. The resulting <i>syn-</i>chlorohydrins are produced with good to excellent diastereoselectivity in high enantiopurity and provide new opportunities for the synthesis of carbohydrates
Additional file 2: of Cultivation of stable, reproducible microbial communities from different fecal donors using minibioreactor arrays (MBRAs)
Stabilization of MBRA communities. Plot of Average Bray-Curtis (BC) dissimilarities on days 8-21 across replicate reactors
Total Synthesis of Amphirionin‑4
The
first total synthesis of amphirionin-4 has been achieved using
a combination of cross-coupling strategies to access the polyene side
chain and a chlorohydrin-based approach to construct the tetrahydrofuranol
core. The remote C9-stereocenter was introduced through a Nozaki–Hiyama–Kishi
coupling that proceeded with remote stereoinduction
A Short, Organocatalytic Formal Synthesis of (−)-Swainsonine and Related Alkaloids
A short synthesis of hydroxyalkyl dihydropyrroles has been developed that involves the coupling of propargylamines with α-chloroaldehydes, followed by Lindlar reduction and a one-pot epoxide formation/opening sequence. The application of this process to the synthesis of unnatural iminosugars and a formal synthesis of (−)-swainsonine is described