Congenital cerebellar hypoplasia associated with BVD-MD virus infection in a naturally infected calf

The objectives of the present study were to describe pathomorphological and immunohistochemical features of congenital cerebellar hypoplasia associated with natural BVD-MD virus infection in a Holstein-Friesian calf. The characteristic macroscopical lesion was cerebellar hypoplasia, almost completely absent, with hydrocephaly. Cerebellar changes were cortical destruction, destructive changes of granule and Purkinje cells and irregular cavity formation of the folia. The positive antibody reaction against the BVD-MD virus was observed in the CNS, but not in the eyes and peripheral nerves

Congenital cerebellar hypoplasia associated with BVD-MD virus infection in a naturally infected calf

The objectives of the present study were to describe pathomorphological and immunohistochemical features of congenital cerebellar hypoplasia associated with natural BVD-MD virus infection in a Holstein-Friesian calf. The characteristic macroscopical lesion was cerebellar hypoplasia, almost completely absent, with hydrocephaly. Cerebellar changes were cortical destruction, destructive changes of granule and Purkinje cells and irregular cavity formation of the folia. The positive antibody reaction against the BVD-MD virus was observed in the CNS, but not in the eyes and peripheral nerves

Nalaz tetratiridija u peritonealnoj šupljini sijamske mačke.

Peritoneal tetrathyridiosis in a 6-year-old male Siamese cat is described. Abdominal distension and mass were determined at clinical examination. Parasitic materials, which were free in the peritoneum and attached to the inner body wall and viscera, were viewed macroscopically. Microscopically chronic multiple pyogranulomatous peritonitis, hepatitis and splenitis were observed. Parasites were identified as tetrathyridia of Mesocestoides sp., probably Mesocestoides lineatus.Opisana je peritonealna tetratiridioza u šestogodišnje sijamske mačke. Kod kliničke pretrage ustanovljena je abdominalna distenzija i povećana masa. Makroskopski su utvrđeni slobodni parazitski elementi u trbušnoj šupljini te priljubljeni na unutarnju stranu trbušne stijenke i na crijeva. Mikroskopski je ustanovljen kronični multipli piogranulomatozni peritonitis, hepatitis i splenitis. Identificiran je tetratiridij Mesocestoides, vjerojatno Mesocestoides lineatus

Detection of progressive and regressive phase and LINE-1 retrotransposon in transfected dogs with transmissible venereal tumor during chemotherapy

WOS: 000445944700005PubMed: 30041285Canine transmissible venereal tumor (CTVT) is a tumor that commonly occurs in genital and extragenital sites of both genders. Long interspersed nuclear elements (LINE-1) retrotransposon has a pivotal role in allogenic transfection among uncontrolled dog populations. This study aimed to perform pathomorphological, immunohistochemical, and in situ polymerase chain reaction (PCR) evaluation of CTVT (n = 18) in transfected dogs during chemotherapy. Immunohistochemically, tumor phases were investigated by using specific markers (CD3, CD4, CD8, CD79, and transforming growth factor beta [TGF-beta]), and investigated an amplified specific sequence of TVT LINE-1 retrotransposon by in situ PCR. Polyhedral-shaped neoplastic cells that had large, round, hypo/hyperchromatic nuclei and eosinophilic cytoplasm were detected. All marker results were positive, especially in the early weeks of recovery. CD4 and TGF-beta markers were conspicuously positive at the initial stage. In situ PCR LINE-1 sequence was initially positive in only four cases. It is believed that the CD and TGF-beta markers provide phase identification at tumor initiation and during chemotherapy. It is thought that presence of T and B lymphocytes, which have roles in cellular and humoral immunity, is needed so that regression of the tumor is possible.Ankara University Scientific Research Projects, Turkey [10B3338008/2014]This study was supported by the Ankara University Scientific Research Projects (project No. 10B3338008/2014), Turkey