Faculty of Veterinary Medicine University of Zagreb
Abstract
The objectives of the present study were to describe pathomorphological and immunohistochemical features
of congenital cerebellar hypoplasia associated with natural BVD-MD virus infection in a Holstein-Friesian calf.
The characteristic macroscopical lesion was cerebellar hypoplasia, almost completely absent, with hydrocephaly.
Cerebellar changes were cortical destruction, destructive changes of granule and Purkinje cells and irregular
cavity formation of the folia. The positive antibody reaction against the BVD-MD virus was observed in the
CNS, but not in the eyes and peripheral nerves