Summer melt regulates winter glacier flow speeds throughout Alaska

pre-printPredicting how climate change will affect glacier and ice sheet flow speeds remains a large hurdle toward accurate sea level rise forecasting. Increases in surface melt rates are known to accelerate glacier flow in summer, whereas in winter, flow speeds are believed to be relatively invariant. Here we show that wintertime flow speeds on nearly all major glaciers throughout Alaska are not only variable but are inversely related to melt from preceding summers. For each additional meter of summertime melt, we observe an 11% decrease in wintertime velocity on glaciers of all sizes, geometries, climates, and bed types. This dynamic occurs because interannual differences in summertime melt affect how much water is retained in the subglacial system during winter. The ubiquity of the dynamic indicates it occurs globally on glaciers and ice sheets not frozen to their beds and thus constitutes a new mechanism affecting sea level rise projections

Systematics of Moduli Stabilization, Inflationary Dynamics and Power Spectrum

We study the scalar sector of type IIB superstring theory compactified on Calabi-Yau orientifolds as a place to find a mechanism of inflation in the early universe. In the large volume limit, one can stabilize the moduli in stages using perturbative method. We relate the systematics of moduli stabilization with methods to reduce the number of possible inflatons, which in turn lead to a simpler inflation analysis. Calculating the order-of-magnitude of terms in the equation of motion, we show that the methods are in fact valid. We then give the examples where these methods are used in the literature. We also show that there are effects of non-inflaton scalar fields on the scalar power spectrum. For one of the two methods, these effects can be observed with the current precision in experiments, while for the other method, the effects might never be observable.Comment: 20 pages, JHEP style; v.2 and v.3: typos fixed, discussion and references adde

Respiratory Muscle Paralysis Associated With Colistin, Polymyxin B, and Muscle Relaxants Drugs: A Case Report

Polymyxins B and E (colistin) exert a bactericidal effect on the gram-negative bacterial cell wall, causing permeability changes in the cytoplasmic membrane, leading to cell death. Their use was substantially decreased in clinical practice from the 1970s to 2000s due to their significant nephrotoxicity and neurotoxicity compared to the newly introduced antibiotics. The increasing prevalence of multidrug-resistant gram-negative bacteria infections in this century has led to an upsurge in the use of these “older” drugs. Respiratory paralysis caused by neuromuscular blockage associated with the use of polymyxin B and E was reported mostly in literature published in the 1960s to 1970s with a few reports after 2000. In addition, such a reaction might be enhanced by the presence of other classes of drugs. We report a case of polymyxin B and E–induced apnea in a patient receiving “muscle relaxants.

Multiple Inflation, Cosmic String Networks and the String Landscape

Motivated by the string landscape we examine scenarios for which inflation is a two-step process, with a comparatively short inflationary epoch near the string scale and a longer period at a much lower energy (like the TeV scale). We quantify the number of $e$-foldings of inflation which are required to yield successful inflation within this picture. The constraints are very sensitive to the equation of state during the epoch between the two inflationary periods, as the extra-horizon modes can come back inside the horizon and become reprocessed. We find that the number of $e$-foldings during the first inflationary epoch can be as small as 12, but only if the inter-inflationary period is dominated by a network of cosmic strings (such as might be produced if the initial inflationary period is due to the brane-antibrane mechanism). In this case a further 20 $e$-foldings of inflation would be required at lower energies to solve the late universe's flatness and horizon problems.Comment: 27 pages, 6 figures; v2: refences adde

Precautionary advice about mobile phones: Public understandings and intended responses

The official published version can be obtained from the link below - Copyright @ Taylor & FrancisThere is a widespread academic and policy debate about public responses to precaution in public health campaigns. This paper explores these issues in relation to the precautionary stance adopted in the UK around the regulation of mobile telecommunications. The aim of the paper is to examine the nature of attitudes to precaution, and the way in which these, along with other relevant variables, relate to the intention to adopt relevant behaviours. The results from an experimental study (n = 173) indicate that people distinguish between two dimensions of precaution: firstly in relation to its value or necessity per se and secondly as anchored to notions of governance. The two variables differentially relate to other variables including trust and uncertainty, and are predictive of intended behaviour change indirectly, through worry about mobile phone risks. Precautionary advice was generally interpreted as causing concern rather than providing reassurance. The results suggest that precaution may be considered a valuable stance but this does not mean that it is seen as good governance or that it will reduce concern. Whilst the discourse of precaution is aimed at reducing concern, it appears that the uptake of relevant behaviours is largely triggered by worry

Mapping Snowmelt Progression in the Upper Indus Basin with Synthetic Aperture Radar

The Indus River is a vital resource for food security, ecosystem services, hydropower, and economy for millions of people living in Pakistan, India, China, and Afghanistan. Glacier and snowmelt from the high altitude Himalaya, Karakoram, and Hindu Kush mountain ranges are the largest drivers of discharge in the upper Indus Basin (UIB), and contribute significantly to Indus flows. Complex climatology and topography, coupled with the challenges of field study and meteorological measurement in these rugged ranges, elicit notable uncertainties in predicting seasonal runoff as well as cryospheric response to changes in climate. Here we utilize Sentinel-1 synthetic aperture radar (SAR) imagery to track ablation season development of wet snow in the Shigar Watershed of the Karakoram Mountains in Pakistan from 2015 to 2018. We exploit opportune local image acquisition times to highlight diurnal differences in radar indications of wet snow, and examine the spatial and temporal contexts of radar diurnal differences for 2015, 2017, and 2018 ablation seasons. Radar classifications for each ablation season show spatial and temporal patterns that indicate a dry winter snowpack undergoing diurnal surface melt-refreeze cycles, transitioning to surface snow that remains wet both day and night, and finally snow free conditions following melt out. Diurnally differing SAR signals may offer insights into important snowpack energy balance processes that precede melt out, which could provide useful constraints for both glacier mass balance modeling and runoff forecasting in remote alpine watersheds

Cosmology From Random Multifield Potentials

We consider the statistical properties of vacua and inflationary trajectories associated with a random multifield potential. Our underlying motivation is the string landscape, but our calculations apply to general potentials. Using random matrix theory, we analyze the Hessian matrices associated with the extrema of this potential. These potentials generically have a vast number of extrema. If the cross-couplings (off-diagonal terms) are of the same order as the self-couplings (diagonal terms) we show that essentially all extrema are saddles, and the number of minima is effectively zero. Avoiding this requires the same separation of scales needed to ensure that Newton's constant is stable against radiative corrections in a string landscape. Using the central limit theorem we find that even if the number of extrema is enormous, the typical distance between extrema is still substantial -- with challenging implications for inflationary models that depend on the existence of a complicated path inside the landscape.Comment: revtex, 3 figures, 10 pages v2 refs adde

The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15

Sound and acceleration are detected by hair bundles, mechanosensory structures located at the apical pole of hair cells in the inner ear. The different elements of the hair bundle, the stereocilia and a kinocilium, are interconnected by a variety of link types. One of these links, the tip link, connects the top of a shorter stereocilium with the lateral membrane of an adjacent taller stereocilium and may gate the mechanotransducer channel of the hair cell. Mass spectrometric and Western blot analyses identify the tip-link antigen, a hitherto unidentified antigen specifically associated with the tip and kinocilial links of sensory hair bundles in the inner ear and the ciliary calyx of photoreceptors in the eye, as an avian ortholog of human protocadherin-15, a product of the gene for the deaf/blindness Usher syndrome type 1F/DFNB23 locus. Multiple protocadherin-15 transcripts are shown to be expressed in the mouse inner ear, and these define four major isoform classes, two with entirely novel, previously unidentified cytoplasmic domains. Antibodies to the three cytoplasmic domain-containing isoform classes reveal that each has a different spatiotemporal expression pattern in the developing and mature inner ear. Two isoforms are distributed in a manner compatible for association with the tip-link complex. An isoform located at the tips of stereocilia is sensitive to calcium chelation and proteolysis with subtilisin and reappears at the tips of stereocilia as transduction recovers after the removal of calcium chelators. Protocadherin-15 is therefore associated with the tip-link complex and may be an integral component of this structure and/or required for its formatio

Constraints on Brane Inflation and Cosmic Strings

By considering simple, but representative, models of brane inflation from a single brane-antibrane pair in the slow roll regime, we provide constraints on the parameters of the theory imposed by measurements of the CMB anisotropies by WMAP including a cosmic string component. We find that inclusion of the string component is critical in constraining parameters. In the most general model studied, which includes an inflaton mass term, as well as the brane-antibrane attraction, values n_s < 1.02 are compatible with the data at 95 % confidence level. We are also able to constrain the volume of internal manifold (modulo factors dependent on the warp factor) and the value of the inflaton field to be less than 0.66M_P at horizon exit. We also investigate models with a mass term. These observational considerations suggest that such models have r < 2*10^-5, which can only be circumvented in the fast roll regime, or by increasing the number of antibranes. Such a value of r would not be detectable in CMB polarization experiment likely in the near future, but the B-mode signal from the cosmic strings could be detectable. We present forecasts of what a similar analysis using PLANCK data would yield and find that it should be possible to rule out G\mu > 6.5*10^-8 using just the TT, TE and EE power spectra.Comment: 11 pages, 3 figures, revtex4, typos corrected, references adde