Interrelationships between demographic, psychosocial, and academic characteristics and GED attainment among at-risk youth

This exploratory-descriptive research examines demographic, psychosocial, and academic characteristics of at-risk youth (N = 111) who attempted the General Educational Development (GED) Tests. Among students who passed and did not pass the GED Tests, numerous significant relationships emerged. Non-passers were more likely than passers to leave school for academic environment reasons (t = 2.21, df = 109, p \u3c .05). As compared with those who passed the GED Tests, a greater number of moderately strong interrelationships among demographic, psychosocial, and academic characteristics emerged among students who did not pass. Most notably, for non-passers, significantly strong and positive relationships emerged between academic environment reasons for leaving school and two other variables: family reasons for leaving school (r = .55, p \u3c .01) and psychosocial reasons for leaving school (r = .57, p \u3c .05). In addition, a very strong and negative interrelationship emerged among non-passers between academic environment reasons for leaving school and the poverty indicator of status (r = -.68, p \u3c .01). A multivariate perspective is critical for increasing knowledge regarding the social problem of dropout. Such knowledge is crucial for research and policy formation at the local, state, and national levels as well as for school social work practice and education

The predictive ability of demographic and psychosocial risk factors, school-related characteristics, and service interventions on grade attainment among at-risk elementary school children in a truancy intervention program

The purpose of the current exploratory-descriptive retrospective study was to examine the demographic, school-related, and psychosocial risk factors among at-risk elementary school children (N = 12644) assessed at low and high levels of risk for continuing truancy. The sample was enrolled in 16 statewide program sites of a community-based truancy prevention program in Louisiana, which provided a letter and attendance monitoring for low-risk participants and intensive case management for high-risk participants. Intercorrelations among risk factors and referred services and on-time grade attainment were assessed for a subsample of the high-risk children (n = 6088). Binary logistic regression analyses were conducted to determine which correlates among the demographic, school-related, and psychosocial risk factors and services best predicted on-time grade level at 3 years out among a subsample of the high-risk children (n = 2864). Model fit to the data was modest. Findings showed that race and grade at program admission were significantly associated with on-time grade attainment at 3 years out. African-American participants were less likely to be on time for grade than participants not of African-American ethnicity. Participants in kindergarten were less likely to be on time than children in higher grades of elementary school. Children assessed as unmotivated by their teachers were less likely to be on time for grade at 3 years out than children who were not assessed as unmotivated. Other findings showed that participants who completed educational services were less likely to be on time for their grade than participants who did not receive educational services. Implications for social work practice, education, and research are discussed

Louisiana-Recognized Native American Tribal Needs Assessment: Understanding the Perceptions, Resources, and Challenges Involving Opioid Use Disorder

Executive Summary The Social Research and Evaluation Center (SREC) at the Louisiana State University, College of Human Sciences and Education engaged Louisiana-recognized tribes to investigate their perceptions, resources, and challenges around the Opioid Use Disorder (OUD) crisis in their communities. The outreach and investigative process resulted in attending tribal council meetings, conducting key stakeholder interviews, and administering tribal listening sessions. The discussions and listening sessions facilitated open dialogue about the nature of OUD, prevention, treatment, and recovery as well as identification of strengths and challenges experienced by tribal communities. Tribal citizens reported limited knowledge about help for those experiencing addiction. Knowledge of resources was limited, and misinformation was also revealed. Tribal citizens reported little to no cultural practices that could assist those dealing with addiction. Tribal citizens listed an array of root causes contributing to addiction in their communities including historical and generational trauma. The interactions for this project with Native American citizens opened new channels of communication and established rapport among tribal citizens and the SREC research team to better understand the impact of OUD and identify appropriate solution

Louisiana Children\u27s Trust Fund Annual Report 2021-2022

Child abuse and neglect is a leading factor in the staggeringly high rates of child mortality in Louisiana. In 2017, Louisiana had 44,793 total referrals for child abuse and neglect of which 19,851 were investigated (CWLA, 2019). Child abuse and neglect can have multiple detrimental effects on a child’s physical, psychological, and behavioral health. Effective prevention efforts are critical to ensuring the immediate and long-term safety and well-being of children in Louisiana. Each year, LCTF selects high-quality proposals and funds a range of prevention efforts to protect children, strengthen family well-being, and educate the public about children’s safety. Local, national, and global events have greatly impacted our communities since 2020. These events included various social, economic, political, and medical crises. Events such as the COVID-19 pandemic, led to political, social unrest and the resulting business closures have caused a great deal of instability in communities around the state. It has taken a toll on individuals’ mental health and well-being. The Child Welfare Information Gateway (2022) says that family wellbeing is an important factor in reducing the likelihood of child abuse and neglect. These events do not impact everyone equally. However, difficult times for some can be felt more severely by other, even more so for the most marginalized populations in our community. Understanding the broader context of how policies and events have impacted our communities is important. These events have caused many to examine bias, resources available for families at risk, and how communities and individuals are making decisions for their children. It has also identified barriers that prevent some children and families from seeking the opportunities and accessing the resources they need to thrive

HacA-Independent Functions of the ER Stress Sensor IreA Synergize with the Canonical UPR to Influence Virulence Traits in Aspergillus fumigatus

Endoplasmic reticulum (ER) stress is a condition in which the protein folding capacity of the ER becomes overwhelmed by an increased demand for secretion or by exposure to compounds that disrupt ER homeostasis. In yeast and other fungi, the accumulation of unfolded proteins is detected by the ER-transmembrane sensor IreA/Ire1, which responds by cleaving an intron from the downstream cytoplasmic mRNA HacA/Hac1, allowing for the translation of a transcription factor that coordinates a series of adaptive responses that are collectively known as the unfolded protein response (UPR). Here, we examined the contribution of IreA to growth and virulence in the human fungal pathogen Aspergillus fumigatus. Gene expression profiling revealed that A. fumigatus IreA signals predominantly through the canonical IreA-HacA pathway under conditions of severe ER stress. However, in the absence of ER stress IreA controls dual signaling circuits that are both HacA-dependent and HacA-independent. We found that a ΔireA mutant was avirulent in a mouse model of invasive aspergillosis, which contrasts the partial virulence of a ΔhacA mutant, suggesting that IreA contributes to pathogenesis independently of HacA. In support of this conclusion, we found that the ΔireA mutant had more severe defects in the expression of multiple virulence-related traits relative to ΔhacA, including reduced thermotolerance, decreased nutritional versatility, impaired growth under hypoxia, altered cell wall and membrane composition, and increased susceptibility to azole antifungals. In addition, full or partial virulence could be restored to the ΔireA mutant by complementation with either the induced form of the hacA mRNA, hacAi, or an ireA deletion mutant that was incapable of processing the hacA mRNA, ireAΔ10. Together, these findings demonstrate that IreA has both HacA-dependent and HacA-independent functions that contribute to the expression of traits that are essential for virulence in A. fumigatus

Identification of Functional Networks of Estrogen- and c-Myc-Responsive Genes and Their Relationship to Response to Tamoxifen Therapy in Breast Cancer

BACKGROUND: Estrogen is a pivotal regulator of cell proliferation in the normal breast and breast cancer. Endocrine therapies targeting the estrogen receptor are effective in breast cancer, but their success is limited by intrinsic and acquired resistance. METHODOLOGY/PRINCIPAL FINDINGS: With the goal of gaining mechanistic insights into estrogen action and endocrine resistance, we classified estrogen-regulated genes by function, and determined the relationship between functionally-related genesets and the response to tamoxifen in breast cancer patients. Estrogen-responsive genes were identified by transcript profiling of MCF-7 breast cancer cells. Pathway analysis based on functional annotation of these estrogen-regulated genes identified gene signatures with known or predicted roles in cell cycle control, cell growth (i.e. ribosome biogenesis and protein synthesis), cell death/survival signaling and transcriptional regulation. Since inducible expression of c-Myc in antiestrogen-arrested cells can recapitulate many of the effects of estrogen on molecular endpoints related to cell cycle progression, the estrogen-regulated genes that were also targets of c-Myc were identified using cells inducibly expressing c-Myc. Selected genes classified as estrogen and c-Myc targets displayed similar levels of regulation by estrogen and c-Myc and were not estrogen-regulated in the presence of siMyc. Genes regulated by c-Myc accounted for 50% of all acutely estrogen-regulated genes but comprised 85% (110/129 genes) in the cell growth signature. siRNA-mediated inhibition of c-Myc induction impaired estrogen regulation of ribosome biogenesis and protein synthesis, consistent with the prediction that estrogen regulates cell growth principally via c-Myc. The 'cell cycle', 'cell growth' and 'cell death' gene signatures each identified patients with an attenuated response in a cohort of 246 tamoxifen-treated patients. In multivariate analysis the cell death signature was predictive independent of the cell cycle and cell growth signatures. CONCLUSIONS/SIGNIFICANCE: These functionally-based gene signatures can stratify patients treated with tamoxifen into groups with differing outcome, and potentially identify distinct mechanisms of tamoxifen resistance