The peculiar velocities of rich clusters in the hot and cold dark matter scenarios

We present the results of a study of the peculiar velocities of rich clusters of galaxies. The peculiar motion of rich clusters in various cosmological scenarios is of interest for a number of reasons. Observationally, one can measure the peculiar motion of clusters to greater distances than galaxies because cluster peculiar motions can be determined to greater accuracy. One can also test the slope of distance indicator relations using clusters to see if galaxy properties vary with environment. We have used N-body simulations to measure the amplitude and rms cluster peculiar velocity as a function of bias parameter in the hot and cold dark matter scenarios. In addition to measuring the mean and rms peculiar velocity of clusters in the two models, we determined whether the peculiar velocity vector of a given cluster is well aligned with the gravity vector due to all the particles in the simulation and the gravity vector due to the particles present only in the clusters. We have investigated the peculiar velocities of rich clusters of galaxies in the cold dark matter and hot dark matter galaxy formation scenarios. We have derived peculiar velocities and associated errors for the scenarios using four values of the bias parameter ranging from b = 1 to b = 2.5. The growth of the mean peculiar velocity with scale factor has been determined and compared to that predicted by linear theory. In addition, we have compared the orientation of force and velocity in these simulations to see if a program such as that proposed by Bertschinger and Dekel (1989) for elliptical galaxy peculiar motions can be applied to clusters. The method they describe enables one to recover the density field from large scale redshift distance samples. The method makes it possible to do this when only radial velocities are known by assuming that the velocity field is curl free. Our analysis suggests that this program if applied to clusters is only realizable for models with a low value of the bias parameter, i.e., models in which the peculiar velocities of clusters are large enough that the errors do not render the analysis impracticable

The dynamics of Abell 2634

We have amassed a large sample of velocity data for the cluster of galaxies Abell 2634 which contains the wide-angle tail (WAT) radio source 3C 465. Robust indicators of location and scale and their confidence intervals are used to determine if the cD galaxy, containing the WAT, has a significant peculiar motion. We find a cD peculiar radial velocity of 219 plus or minus 98 km s(exp -1). Further dynamical analyses, including substructure and normality tests, suggest that A 2634 is an unrelaxed cluster whose radio source structure may be bent by the turbulent gas of a recent cluster-subcluster merger

The rotation curves of dwarf galaxies: a problem for Cold Dark Matter?

We address the issue of accuracy in recovering density profiles from observations of rotation curves of galaxies. We ``observe'' and analyze our models in much the same way as observers do the real galaxies. We find that the tilted ring model analysis produces an underestimate of the central rotational velocity. In some cases the galaxy halo density profile seems to have a flat core, while in reality it does not. We identify three effects, which explain the systematic biases: (1) inclination (2), small bulge, and (3) bar. The presence of even a small non-rotating bulge component reduces the rotation velocity. In the case of a disk with a bar, the underestimate of the circular velocity is larger due to a combination of non-circular motions and random velocities. Signatures of bars can be difficult to detect in the surface brightness profiles of the model galaxies. The variation of inclination angle and isophote position angle with radius are more reliable indicators of bar presence than the surface brightness profiles. The systematic biases in the central ~ 1 kpc of galaxies are not large. Each effect separately gives typically a few kms error, but the effects add up. In some cases the error in circular velocity was a factor of two, but typically we get about 20 percent. The result is the false inference that the density profile of the halo flattens in the central parts. Our observations of real galaxies show that for a large fraction of galaxies the velocity of gas rotation (as measured by emission lines) is very close to the rotation of stellar component (as measured by absorption lines). This implies that the systematic effects discussed in this paper are also applicable both for the stars and emission-line gas.Comment: ApJ, in press, 30 pages, Latex, 21 .eps figure

Is there Evidence for Flat Cores in the Halos of Dwarf Galaxies?: The Case of NGC 3109 and NGC 6822

Two well studied dwarf galaxies -- NGC 3109 and NGC 6822 -- present some of the strongest observational support for a flat core at the center of galactic dark matter (DM) halos. We use detailed cosmologically motivated numerical models to investigate the systematics and the accuracy of recovering parameters of the galaxies. Some of our models match the observed structure of the two galaxies remarkably well. Our analysis shows that the rotation curves of these two galaxies are instead quite compatible with their DM halos having steep cuspy density profiles. The rotation curves in our models are measured using standard observational techniques. The models reproduce the rotation curves of both galaxies, the disk surface brightness profiles as well as the profile of isophotal ellipticity and position angle. The models are centrally dominated by baryons; however, the dark matter component is globally dominant. The simulated disk mass is marginally consistent with a stellar mass-to-light ratio in agreement with the observed colors. We show that non-circular motions combined with gas pressure support and projection effects results in a large underestimation of the circular velocity in the central $\sim 1$ kpc region, creating the illusion of a constant density core. Although the systematic effects mentioned above are stronger in barred systems, they are also present in axisymetric disks. Our results strongly suggest that there is no contradiction between the observed rotation curves in dwarf galaxies and the cuspy central dark matter density profiles predicted by Cold Dark Matter models.Comment: Accepted for publication in the ApJ. New discussion, figures and one appendix. High resolution version at:http://www.astro.washington.edu/octavio/N3109_paper.ps.g

HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype.

Aortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine SNPs associated with the extent of abdominal aortic calcification (n = 9,417) or descending thoracic aortic calcification (n = 8,422). Two genetic loci, HDAC9 and RAP1GAP, were associated with abdominal aortic calcification at a genome-wide level (P < 5.0 × 10-8). No SNPs were associated with thoracic aortic calcification at the genome-wide threshold. Increased expression of HDAC9 in human aortic smooth muscle cells promoted calcification and reduced contractility, while inhibition of HDAC9 in human aortic smooth muscle cells inhibited calcification and enhanced cell contractility. In matrix Gla protein-deficient mice, a model of human vascular calcification, mice lacking HDAC9 had a 40% reduction in aortic calcification and improved survival. This translational genomic study identifies the first genetic risk locus associated with calcification of the abdominal aorta and describes a previously unknown role for HDAC9 in the development of vascular calcification

S-allylmercaptocysteine reduces carbon tetrachloride-induced hepatic oxidative stress and necroinflammation via nuclear factor kappa B-dependent pathways in mice

Purpose To study the protective effects and underlying molecular mechanisms of SAMC on carbon tetrachloride (CCl4)-induced acute hepatotoxicity in the mouse model. Methods Mice were intraperitoneally injected with CCl4 (50 μl/kg; single dose) to induce acute hepatotoxicity with or without a 2-h pre-treatment of SAMC intraperitoneal injection (200 mg/kg; single dose). After 8 h, the blood serum and liver samples of mice were collected and subjected to measurements of histological and molecular parameters of hepatotoxicity. Results SAMC reduced CCl4-triggered cellular necrosis and inflammation in the liver under histological analysis. Since co-treatment of SAMC and CCl4 enhanced the expressions of antioxidant enzymes, reduced the nitric oxide (NO)-dependent oxidative stress, and inhibited lipid peroxidation induced by CCl4. SAMC played an essential antioxidative role during CCl4-induced hepatotoxicity. Administration of SAMC also ameliorated hepatic inflammation induced by CCl4 via inhibiting the activity of NF-κB subunits p50 and p65, thus reducing the expressions of pro-inflammatory cytokines, mediators, and chemokines, as well as promoting pro-regenerative factors at both transcriptional and translational levels. Conclusions Our results indicate that SAMC mitigates cellular damage, oxidative stress, and inflammation in CCl4-induced acute hepatotoxicity mouse model through regulation of NF-κB. Garlic or garlic derivatives may therefore be a potential food supplement in the prevention of liver damage

Effectiveness of initiating biologics in severe asthma patients with high steroid exposure

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Real-life biomarker response to anti-IL5 and anti-IgE therapies in severe asthma patients

Funding: This study was conducted by the Observational and Pragmatic Research Institute (OPRI) Pte Ltd and was partially funded by Optimum Patient Care Global and AstraZeneca Ltd. No funding was received by OPRI for its contribution.Peer reviewedPostprin