2 research outputs found
Leiomiomas cut谩neos: revisi贸n clinicopatol贸gica y epidemiol贸gica
Get PDFFundamento. Los leiomiomas cut谩neos, superficiales o suprafasciales, se dividen en tres variantes: piloleiomiomas
(PL), angioleiomiomas (AL) y leiomiomas genitales (LG) que
incluyen las formas vulvares, escrotales y areolares. El objetivo fue establecer las caracter铆sticas clinicohistol贸gicas y
la incidencia de cada variante, y las posibles asociaciones
con neoplasias internas.
Material y m茅todos. Se revisaron 255 casos de leiomiomas
cut谩neos diagnosticados entre 1982 y 2018 en los servicios
de Anatom铆a Patol贸gica de tres centros hospitalarios (Navarra y Alicante). Se describieron y compararon variables demogr谩ficas, cl铆nicas, histol贸gicas e inmunohistoqu铆micas.
Resultados. La incidencia en Navarra de PL fue 4,3 casos
por a帽o y mill贸n de habitantes, de AL 20 y de LG 1,4. Las
formas cut谩neas suponen aproximadamente el 3,5 % del
total de leiomiomas. La poblaci贸n con PL sufri贸 m谩s frecuentemente c谩ncer de mama (OR= 4,8; IC95%: 1,3-17,4;
p= 0,006). Los leiomiomas areolares son de peque帽o tama帽o, acompa帽ados de dolor local, predominantemente
fasciculares o s贸lidos, con muy rara afectaci贸n del tejido
celular subcut谩neo y escasa atipia. Esto contrasta con el
resto de LG, de tama帽o medio y rara vez dolorosos, predominantemente nodulares, con frecuente afectaci贸n del
tejido celular subcut谩neo y atipia.
Conclusiones. Se aporta informaci贸n sobre las caracter铆sticas clinicohistol贸gicas de las distintas variantes de leiomiomas, seg煤n las cuales deber铆a replantearse la clasificaci贸n de los leiomiomas areolares fuera del grupo de LG. Se
detect贸 una asociaci贸n entre PL y carcinoma de mama que
deber谩 confirmarse en futuros estudios para determinar si
este leiomioma constituye un marcador de riesgo de c谩ncer
de mama en mujeres.Background. Cutaneous, superficial and or suprafascial leiomyoma are divided into three variants: piloleiomyomas (PL),
angioleiomyomas (AL) and genital leiomyomas (GL) that include the vulvar, scrotal and areolar forms. This study set
out to establish the clinical and histological characteristics
and incidence of each variant, and any likely associations
with internal neoplasms.
Methods. A review was carried out of 255 cases of cutaneous leiomyomas diagnosed between 1982 and 2018 at the
Pathology departments of three hospitals (Navarra and Alicante). Demographic, clinical, histological and immunohistochemical variables were described and compared.
Results. The incidence of PL in Navarra was 4.3 cases per
million inhabitants a year, with another 20 cases of AL and
1.4 cases of GL. Cutaneous forms make up approximately
3.5% of the total leiomyomas. The population with PL suffered more frequently from breast cancer (OR= 4.8; CI 95%:
1.3-17.4; p= 0.006). Nipple leiomyomas are small, accompanied by localised pain, and are predominantly fascicular
or solid, with very infrequent effect on the subcutaneous
cellular tissue and scarce atypia. This makes for a contrast
with the other GLs, which are medium sized and infrequently painful, predominantly nodular, and frequent effect on the
subcutaneous tissue and atypia.
Conclusions. The information provided here about the clinical and histological characteristics of the different varieties
of leiomyomas indicate that there is a need to reconsider
the classification of nipple leiomyomas outside the group of
GLs. An association between PL and breast carcinoma was
detected, which needs to be confirmed in future studies so
as to determine if this leiomyoma is a risk marker for breast
cancer
Leiomiomas cut谩neos: revisi贸n clinicopatol贸gica y epidemiol贸gica
Get PDFFundamento. Los leiomiomas cut谩neos, superficiales o suprafasciales, se dividen en tres variantes: piloleiomiomas
(PL), angioleiomiomas (AL) y leiomiomas genitales (LG) que
incluyen las formas vulvares, escrotales y areolares. El objetivo fue establecer las caracter铆sticas clinicohistol贸gicas y
la incidencia de cada variante, y las posibles asociaciones
con neoplasias internas.
Material y m茅todos. Se revisaron 255 casos de leiomiomas
cut谩neos diagnosticados entre 1982 y 2018 en los servicios
de Anatom铆a Patol贸gica de tres centros hospitalarios (Navarra y Alicante). Se describieron y compararon variables demogr谩ficas, cl铆nicas, histol贸gicas e inmunohistoqu铆micas.
Resultados. La incidencia en Navarra de PL fue 4,3 casos
por a帽o y mill贸n de habitantes, de AL 20 y de LG 1,4. Las
formas cut谩neas suponen aproximadamente el 3,5 % del
total de leiomiomas. La poblaci贸n con PL sufri贸 m谩s frecuentemente c谩ncer de mama (OR= 4,8; IC95%: 1,3-17,4;
p= 0,006). Los leiomiomas areolares son de peque帽o tama帽o, acompa帽ados de dolor local, predominantemente
fasciculares o s贸lidos, con muy rara afectaci贸n del tejido
celular subcut谩neo y escasa atipia. Esto contrasta con el
resto de LG, de tama帽o medio y rara vez dolorosos, predominantemente nodulares, con frecuente afectaci贸n del
tejido celular subcut谩neo y atipia.
Conclusiones. Se aporta informaci贸n sobre las caracter铆sticas clinicohistol贸gicas de las distintas variantes de leiomiomas, seg煤n las cuales deber铆a replantearse la clasificaci贸n de los leiomiomas areolares fuera del grupo de LG. Se
detect贸 una asociaci贸n entre PL y carcinoma de mama que
deber谩 confirmarse en futuros estudios para determinar si
este leiomioma constituye un marcador de riesgo de c谩ncer
de mama en mujeres.Background. Cutaneous, superficial and or suprafascial leiomyoma are divided into three variants: piloleiomyomas (PL),
angioleiomyomas (AL) and genital leiomyomas (GL) that include the vulvar, scrotal and areolar forms. This study set
out to establish the clinical and histological characteristics
and incidence of each variant, and any likely associations
with internal neoplasms.
Methods. A review was carried out of 255 cases of cutaneous leiomyomas diagnosed between 1982 and 2018 at the
Pathology departments of three hospitals (Navarra and Alicante). Demographic, clinical, histological and immunohistochemical variables were described and compared.
Results. The incidence of PL in Navarra was 4.3 cases per
million inhabitants a year, with another 20 cases of AL and
1.4 cases of GL. Cutaneous forms make up approximately
3.5% of the total leiomyomas. The population with PL suffered more frequently from breast cancer (OR= 4.8; CI 95%:
1.3-17.4; p= 0.006). Nipple leiomyomas are small, accompanied by localised pain, and are predominantly fascicular
or solid, with very infrequent effect on the subcutaneous
cellular tissue and scarce atypia. This makes for a contrast
with the other GLs, which are medium sized and infrequently painful, predominantly nodular, and frequent effect on the
subcutaneous tissue and atypia.
Conclusions. The information provided here about the clinical and histological characteristics of the different varieties
of leiomyomas indicate that there is a need to reconsider
the classification of nipple leiomyomas outside the group of
GLs. An association between PL and breast carcinoma was
detected, which needs to be confirmed in future studies so
as to determine if this leiomyoma is a risk marker for breast
cancer
