Divergent Construction of Nitrogen-Containing Polycyclic Compounds with a Dearomatization Strategy

The oxidative dearomatization of para-substituted <i>o</i>-alkynylanilines afforded 2-alkynyl cyclohexadienimines, which can act as active substrates for reaction with electron-rich styrenes. The reaction is metal-controlled. Bi(OTf)₃-catalyzed reactions afforded 3,4-dihydro-cyclopenta[<i>c</i>,<i>d</i>]indoles, and AgOTf-catalyzed reactions provided tricyclic pyrrole derivatives

Divergent Construction of Nitrogen-Containing Polycyclic Compounds with a Dearomatization Strategy

The oxidative dearomatization of para-substituted <i>o</i>-alkynylanilines afforded 2-alkynyl cyclohexadienimines, which can act as active substrates for reaction with electron-rich styrenes. The reaction is metal-controlled. Bi(OTf)₃-catalyzed reactions afforded 3,4-dihydro-cyclopenta[<i>c</i>,<i>d</i>]indoles, and AgOTf-catalyzed reactions provided tricyclic pyrrole derivatives

Divergent Construction of Nitrogen-Containing Polycyclic Compounds with a Dearomatization Strategy

The oxidative dearomatization of para-substituted <i>o</i>-alkynylanilines afforded 2-alkynyl cyclohexadienimines, which can act as active substrates for reaction with electron-rich styrenes. The reaction is metal-controlled. Bi(OTf)₃-catalyzed reactions afforded 3,4-dihydro-cyclopenta[<i>c</i>,<i>d</i>]indoles, and AgOTf-catalyzed reactions provided tricyclic pyrrole derivatives

One-Pot Synthesis of Diarylamines from Two Aromatic Amines via Oxidative Dearomatization–Imino Exchange–Reductive Aromatization

A one-pot synthetic strategy for diarylamines using only aromatic amines as starting materials has been developed. This method involved a PhI(OAc)₂-induced oxidative dearomatization of <i>N</i>-sulfonyl protected para-substituted anilines, a Bi(OTf)₃-catalyzed imino exchange reaction between <i>N</i>-sulfonyl cyclohexadienimines and aromatic amines, and a CF₃COOH/Zn mediated reductive aromatization of the resulting <i>N</i>-aryl cyclohexadienimines

Application of Dearomatization Strategy on the Synthesis of Furoquinolinone and Angelicin Derivatives

The oxidative dearomatization of 3-(3-alkynyl-4-hydroxyphenyl)propanoic acid is combined with a cascade transition-metal catalyzed cyclization/addition/aromatization/lactamization sequence, which provides a novel approach to prepare furoquinolinone and angelicin derivatives in a convergent and efficient manner

Metal-Controlled Cycloaddition of 2‑Alkynyl-1,4-benzoquinones and Styrenyl Systems: Lewis Acid versus π Acid

Metal-controlled cycloaddition of 2-alkynyl-1,4-benzoquinones and electron-rich styrenyl systems were investigated. The density functional theory (DFT) calculations revealed that the regioselectivity of the cycloaddition results from the different activation modes of Bi(OTf)₃ and AuCl

La réforme des rythmes scolaires et les projets éducatifs territoriaux : première analyse des évaluations, bilans et autres expertises réalisés entre 2013 et 2017

Publication du CNESCO (Conseil national d’évaluation du système scolaire)Cette étude se donne pour ambition d’approfondir la réflexion sur la réforme dite des rythmes « scolaires » et/ou « éducatifs » et la mise en place des Projets éducatifs de territoire (PEDT) qui l’accompagne. Elle s’attache à clarifier les enjeux et contours de cette réforme et engage surtout un travail d’analyse secondaire d’une partie des différents travaux et rapports dits « d’évaluation », de « bilan » ou « d’études » politico-administratifs, savants ou experts qui ont récemment été produits sur cette dernière. Ceci conduit à soutenir une double série de questionnements sur l’évolution et les aménagements de cette réforme, l’enchevêtrement des logiques et des modes de problématisation des questions scolaires et éducatives qu’elle promeut, les variétés du «discours éducatif et pédagogique» qu’elle sous-tend, ainsi que sur la forme particulière prise par la «littérature experte », qui accompagne, depuis quelques années, sa mise en œuvre controversée.Ce document s’inscrit dans une série de contributions publiées par le Conseil national d’évaluation du système scolaire (Cnesco) sur la thématique : Justice à l’école et territoires

1,2- and 1,4-Additions of 2‑Alkynylcyclohexadienimines with Aromatic Amines To Access 4‑Amino‑<i>N</i>‑arylindoles and -azepinoindoles

2-Alkynylcyclohexadienimines, derived from the oxidation of 2-alkynylanilines, react with aromatic amines leading to <i>N</i>-arylindoles with a 4-amino substitution. The reaction was metal-controlled, and Bi(OTf)₃ proved to be the best catalyst. The resulting 4-amino <i>N</i>-arylindoles could be converted to azepino[4,3,2-<i>cd</i>]indoles through condensation with aldehydes

Oxidative Nucleophilic Cyclization of 2‑Alkynylanilines with Thiophenols under Metal-Free Conditions

An oxidative nucleophilic cyclization of 2-alkynylanilines with thiophenols under metal-free conditions was developed. The one-pot two-step reaction involves a PhI­(OAc)₂-mediated oxidative dearomatization and a Brønsted acid promoted nucleophilic cyclization. DFT calculations were performed to understand the reaction pathway

Metal-Controlled Cycloaddition of 2‑Alkynyl-1,4-benzoquinones and Styrenyl Systems: Lewis Acid versus π Acid

Metal-controlled cycloaddition of 2-alkynyl-1,4-benzoquinones and electron-rich styrenyl systems were investigated. The density functional theory (DFT) calculations revealed that the regioselectivity of the cycloaddition results from the different activation modes of Bi(OTf)₃ and AuCl