159 research outputs found
DESIGNING, DEVELOPING, AND DELIVERING WARGAMES
On November 16, 2023, Mr. David Redpath, Senior Wargames Designer and member of the Canadian Joint Warfare Centre and Department of National Defence, presented Designing, Developing, and Delivering Wargames for this year’s West Coast Security Conference. The key points discussed were the definition, scope, and usefulness of Wargames; who should partake in Wargaming; and how Wargames are utilised effectively.
Received: 01-20-2024
Revised: 01-28-202
ECONOMIC ANALYSIS OF AN INSTALLED SINGLE DWELLING SEASONAL THERMAL ENERGY STORE WITH VARYING demand:Eurosun 2014
Investigation of concentrating and nonconcentrating evacuated tube solar water heaters using 2D particle imaging velocimetry
DIURNAL REVERSE FLUID FLOW IN THERMOSYPHON EVACUATED TUBE SOLAR WATER HEATERS IN A NORTHERN MARITIME CLIMATE
An Experimental Investigation Of Inclined Thermosyphon Fluid Flow Within An Enclosed Irregular Hexagonal Cavity With Heat Transfer Via Pin-Fins
Post-operative atrial fibrillation is influenced by beta-blocker therapy but not by pre-operative atrial cellular electrophysiology
We investigated whether post-cardiac surgery (CS) new-onset atrial fibrillation (AF) is predicted by pre-CS atrial cellular electrophysiology, and whether the antiarrhythmic effect of beta-blocker therapy may involve pre-CS pharmacological remodeling. Atrial myocytes were obtained from consenting patients in sinus rhythm, just prior to CS. Action potentials and ion currents were recorded using whole-cell patch-clamp technique. Post-CS AF occurred in 53 of 212 patients (25%). Those with post-CS AF were older than those without (67 ± 2 vs 62 ± 1 years, P = 0.005). In cells from patients with post-CS AF, the action potential duration at 50% and 90% repolarization, maximum upstroke velocity, and effective refractory period (ERP) were 13 ± 4 ms, 217 ± 16 ms, 185 ± 10 V/s, and 216 ± 14 ms, respectively (n = 30 cells, 11 patients). Peak L-type Ca2+ current, transient outward and inward rectifier K+ currents, and the sustained outward current were −5.0 ± 0.5, 12.9 ± 2.4, −4.1 ± 0.4, and 9.7 ± 1.0 pA/pF, respectively (13-62 cells, 7-19 patients). None of these values were significantly different in cells from patients without post-CS AF (P > 0.05 for each, 60-279 cells, 29-86 patients), confirmed by multiple and logistic regression. In patients treated >7 days with a beta-blocker pre-CS, the incidence of post-CS AF was lower than in non-beta-blocked patients (13% vs 27%, P = 0.038). Pre-CS beta-blockade was associated with a prolonged pre-CS atrial cellular ERP (P = 0.001), by a similar degree (∼20%) in those with and without post-CS AF. Conclusion: Pre-CS human atrial cellular electrophysiology does not predict post-CS AF. Chronic beta-blocker therapy is associated with a reduced incidence of post-CS AF, unrelated to a pre-CS ERP-prolonging effect of this treatment
Coronary heart disease mortality among young adults in Scotland in relation to social inequalities: time trend study
Objective To examine recent trends and social inequalities in age specific coronary heart disease mortality
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