28 day repeat dose (sub-chronic) toxicity of recombinant Enfuviritide on New zealand white rabbits

Abstract- Enfuvirtide is a first of its class as a fusion inhibitor drug which inhibits the fusion of HIV-1 virus with CD4+ cells on the target organism with a human therapeutic dose of 90mg/twice daily. It is a linear 36 amino acid peptide with the empirical formula C204H30N51O64, and the molecular weight of 4.4Kd. The present study was conducted to investigate the repeat dose toxicity of recombinant Enfuvirtide, which was manufactured inhouse, when administered twice daily subcutaneously for twenty eight consecutive days in New Zealand white rabbits at dose levels of 4.2 mg/kg bw (Therapeutic Dose), 10.5 mg/kg bw (Average Dose) and 21.0 mg/kg bw (High Dose) in comparison with synthetic enfuvirtide. The animals were observed during this period for mortality/morbidity, clinical signs, body weight, food consumption, hematology and clinical chemistry. At the end of the experimental period all the animals were necropsied and vital organs were weighed and subjected to histopathological examination. In conclusion, No repeated administration of recombinant Enfuvirtide for a period of 28 days did not exert any toxic effects in rabbits at different dose levels

Primary intraosseous mucoepidermoid carcinoma of the maxilla

Primary intraosseous mucoepidermoid carcinoma (PIOC) is an infrequent malignancy of the head and neck that exhibits diverse biological behavior. The rareness of the location for a salivary gland tumor and the clinical and radiographic manifestations, suggestive of an odontogenic lesion often pose a diagnostic challenge. We hereby report such a unique case of central mucoepidermoid carcinoma that presented in an ambiguous manner, developing in the maxilla and intruding into the adjacent vital structures, adding a literature review.Keywords: Mucoepidermoid carcinoma, salivary gland malignancy, maxilla, CT imaging,histopathologic pictur

Dissecting mediastinal pseudocyst presenting with dysphagia: Role of multimodality imaging

Pancreatic pseudocysts are the most common cystic lesions of the pancreas, accounting for 75-80% of such masses. Pancreaticpseudocyst with mediastinal extension is a rare clinical entity. Extrapancreatic fluid collections are more often detected in the lessersac, in the anterior pararenal space, in the posterior pararenal space, in or around the left lobe of the liver, and in the spleen. Theextra-abdominal extension is infrequent and the mediastinum is a rare site for the extension of the pancreatic secretion. We presenta case of pancreatic mediastinal pseudocyst that presented with palpitations and dysphagia

A rare case report of ruptured distal pica aneurysm and complications

Aneurysms of the distal PICA are rarely encountered and are challenging lesions prone for surgical rupture. PICA is the greatest of the branches of the vertebral artery, and is the causative vessel for aneurysm in the posterior cranial fossa. Common location of aneurysms of PICA is at its junction with vertebral artery. Aneurysms originating from more distant PICA segments are called distal aneurysms and are very rare, with a prevalence of 0.3%. Cerebral infarction and cranial nerve compression occur commonly with rupture of PICA aneurysm. CT angiography has been proposed superior to conventional angiography in patients with ruptured aneurysms presenting with SAH. Surgical treatment of PICA aneurysms depends on the sites of occurrence. Surgical aneurysm clipping and endovascular coiling are the available treatment options to prevent further complications. Here, we report a rare case of distal PICA aneurysm presenting with diffuse SAH and IVH

EFFECT OF VARIOUS PROCESS PARAMETERS ON PUNCH AND DIE DESIGN IN DEEP DRAWING PROCESS

The model is designed in CREO software. Analysis is done in ANSYS software for different materials. In this work static analysis is done for cup and punch to determine the deformation, stress and strain at different load conditions and for different materials by changing the geometry thickness. In this work the stress have been calculated theoretically and as well as using ansys and both results are compared. Modal analysis is done for cup to determine the deformation and frequency for different materials  by changing the geometry thicknesses. Random vibration analysis is done for cup to determine  the directional deformation, shear stress and shear strain for different materials by changing the geometry thickness.In this work the shear stress have been calculated theoretically and as well as using ansys and both results are compared.Transient analysis is done for cup to determine the  deformation, stress and strain for different materials by changing the geometry thickness with respect to time

BALL BURNISHING PROCESS OPTIMIZATION FOR ALUMINUM ALLOY USING TAGUCHI TECHNIQUE

Burnishing is a chip less finishing method which employs a rolling tool pressed against the work piece for achieving of the surface layer. Ball burnishing process is largely considered in industrial cases in order to restructure surface characteristic. Ball burnishing process is employed on 100% aluminum alloy and aluminum (90%, 80%) with Silicon  (+10%, +20%) work piece for current study. In this thesis, work the effect of burnishing parameter like speed, and  feed and the number of passes is going to be examined on the surface quality and its wearing characteristics of aluminum with Silicon (+10%,+20%). For this experimental work, I utilizes Taylor Hobson for measuring surface roughness and Brinell hardness for measuring surface hardness. In this thesis force and number of passes of tool are kept constant. The main aim of this thesis is to compare surface roughness and surface hardness values on 100% aluminum alloy and aluminum (90%, 80%) with Silicon carbide (+10%, +20%) work piec

STATIC AND TRANSIENT ANALYSIS OF COMPOSITE LEAF SPRING

Leaf springs are mainly used in suspension systems to absorb shock loads in automobiles like light motor vehicles, heavy duty trucks and in rail systems. It carries lateral loads, brake torque, driving torque in addition to shock absorbing. This work deals with finding a suitable composite material that can be a replacement for conventional steel leaf spring. The stress and displacements have been calculated using theoretically as well as using ANSYS for steel leaf spring and composite leaf spring. The model is designed in CREO software for the vehicle Mahindra “Model - commander 650 di”. Analysis is done in ANSYS software for different materials (Steel, Kevlar and E-Glass Epoxy). The static analysis is done to determine the deformation, stress and strain for different materials. A comparative study has been made between steel and composite leaf spring with respect to strength and weight. Transient analysis is done to determine the deformation, stress with respect to time for different materials. Fatigue analysis is done to determine the fatigue life for steel, E glass epoxy and Kevlar leaf spring

High-Resolution Ultrasonography of Renal Oncocytoma Presenting with Symptomatic Hematuria and Urinary Bladder Clot Retention—A Rare Occurrence

Renal oncocytomas are asymptomatic, benign tumors often encountered incidentally on various imaging modalities. Renal oncocytomas comprise 5–7% of primary renal neoplasms and are derived from cells of the distal renal tubule. We present a case report of renal oncocytoma in a 22-year-old male having right-sided flank pain and symptomatic gross hematuria with a giant urinary bladder clot retention. The tumor was excised, and the patient underwent laparoscopic partial nephrectomy. Typical features of renal oncocytoma were observed upon histopathological examination of the resected specimen. The patient was catheterized, and bladder irrigation with clot retraction was performed