The Toxic Effects BPA on Fetuses, Infants, and Children

Bisphenol A (BPA) is an organic synthetic compound with the chemical formula (CH3)2C(C6H4OH)2 belonging to the group of diphenylmethane derivatives and bisphenols, with two hydroxyphenyl groups. BPA is the common name for 2,2-(4,4′-dihydroxydiphenyl) propane, IUPAC name 4,4′-(propane-2,2-diyl) diphenol, alternative name p,p′-isopropylidenebisphenol, with two phenol moieties. Its important properties include low vapor pressure, moderate water solubility, and low volatility. It is a colorless solid that is soluble in organic solvents, but poorly soluble in water. BPA is a plastic component produced in large quantities for use chiefly in the production of polycarbonate plastics and epoxy resins. BPA epoxy has a good, broad range of chemical resistance, good physical properties, and is cured using a wide variety of curing agents at ambient temperatures. The present chapter focuses on different toxic effects and the influence of BPA on different stages of human life in fetuses, infants, and children. The chapter also concentrates on how to handle BPA, its treatment, and preventive measures against BPA exposure

Radiological and clinical outcomes in patients undergoing anterior cervical discectomy and fusion: Comparing titanium and PEEK (polyetheretherketone) cages

Objectives: To study clinical and radiological outcomes in patients who had undergone the procedure of anterior cervical discectomy and fusion with titanium or PEEK (polyetheretherketone) cages for cervical disc prolapse.Methods: This is a retrospective/non-randomized study which was conducted at the Combined Military Hospital Peshawar. Study interval was four years from 1st October, 2010 to 31st September, 2014. Total number of included patients were 149. All of the patients had undergone the procedure of anterior cervical discectomy and fusion with titanium or PEEK (polyetheretherketone) cages. All of the patients had plain MRI cervical spine done for diagnosis of anterior cervical disc prolapse.Results: Most of the patients had stenosis at the C5 / C6 (PEEK cage group 63% and titanium cage group 47.6%) and C6 / C7 (PEEK cage group 15.38% and titanium cage group 19.04%) cervical level. Bi-level involvement was also seen. In the patients who complained of brachialgia, total resolution of symptoms was seen after the operation. Three (2.01%) of the patients in titanium cage group, who presented with axial neck pain, continued to complain of pain after the operation. Four (2.6%) of the patients in PEEK (polyetheretherketone) cage group and 2 (1.3%) in titanium cage group complained of pain at the donor site (iliac crest). Fusion rate was 100% with both titanium and PEEK (polyetheretherketone) cages at one year.Conclusion: Results with titanium and PEEK (polyetheretherketone) cages are excellent. There was no significant difference in clinical and radiological outcome between two groups of patients (p \u3e 0.05). Fusion rate was 100% at one year with both cages

Another D in MUDPILES? A Review of Diet-Associated Nondiabetic Ketoacidosis.

Ketogenic diet or very-low-carbohydrate diet gained widespread popularity in the 1990s due to their favorable effects on weight loss and diabetes among others with good short-term safety data. People on ketogenic diets exist in a state of dietary ketosis in which the body production of ketone is equal to consumption and no harmful effects of ketonemia occur. However, in face of stress, the harmless dietary ketosis can lead to profound acid-base disturbances due to massive overproduction of ketone bodies that overwhelms the acid buffer system of the body. A handful of case reports have been published on this topic calling the safety of ketogenic diet into question. In this article, we chronicle a unique case of ketogenic (Atkins) diet-associated ketoacidosis, and we present a comprehensive literature review on the etiology of ketoacidosis

A Bibliometric Analysis of the Top 100 Cited Articles on Hepatic Magnetic Resonance Imaging.

The purpose of this study is to guide the readers to the impact of the articles published on hepatic magnetic resonance imaging (MRI). We searched Scopus using 10 different search terms for hepatic MRI. The selected studies were thoroughly reviewed by two independent authors and any disagreement was sorted out by mutual consensus. The list of articles and journals was downloaded into an excel spreadsheet. Only the top 100 cited articles were selected by mutual consensus among all the authors. These articles were further read in the full-text form and were further categorized into subgroups. Three authors independently reviewed the top 100 selected articles, and subsequently data was extracted from them and analyzed. Our study showed that the highest number of top 100 cited articles on hepatic MRI were from Radiology (30 articles) followed by European Radiology (14 articles). The American Journal of Roentgenology, Radiographics, and Journal of Magnetic Resonance had seven articles each. The United States had the highest number of articles by region. Nineteen other journals contributed only one article each to the list of top 100 cited articles. The contribution of authors to the top 100 cited articles was reviewed; all the authors contributing with more than two articles to the highly cited articles are given in Table 3 in the supplementary material. The maximum number of articles were published during 2009 (14 articles), and for a five-year period, the maximum contribution was made during 2008-2013 (44 articles). Our analysis gives an insight on the frequency of citations of top articles on hepatic MRI, categorizes the subtopics, the timeline of the publications, and contributions from different geographic distributions

Proprotein convertase subtilisin/Kexin type-9 (PCSK-9) inhibitors induced liver injury - a retrospective analysis.

Background: Proprotein convertase subtilisin/Kexin type 9 (PCSK-9) inhibitors induced liver dysfunction in patients with or without previous liver injury, and this is not well discussed in the previous literature. Methods: A total sample of 202 patients were retrospectively reviewed at the University of Missouri, Kansas City, from the year 2015 to 2018 based on predefined selection criteria. Inclusion criteria involved patients with dyslipidemia, with or without PCSK-9 inhibitors, liver function tests and lipid profile at baseline and at a mean of 6-month follow-up. The variables, including age, gender, and confounding factors like other medications (statin, oral antidiabetic, and antihypertensive) induced, or chronic secondary liver diseases causing liver injury were taken into consideration. Exclusion criteria included patients without dyslipidemia. Results: The mean age of the study population was 64 ± 11 years (63% males and 37% females). The lipid profile including triglyceride and cholesterol levels during 6-month followup visit showed a mean of 184 ± 260 and 163 ± 50 mg/dL as compared to that at baseline of 227 ± 603 and 181 ± 70 mg/dL, respectively. In terms of clinical efficacy, a 6-month follows-up showed a drop in triglyceride and cholesterol levels by 38 and 15 mg/dL, respectively. A liver function test at 6 months in patients taking PCSK-9 inhibitors showed an increase in alanine transaminase (ALT) and aspartate transaminase (AST) by 5.8 mg/dL (p = 0.037) and 6.2 mg/dL (p = 0.008), respectively, from baseline values. Conclusion: PCSK-9 inhibitors should be used cautiously with a follow-up liver function test

An overview of enhancing drought tolerance in cotton through manipulating stress resistance genes

Drought stress affects the normal growth of plant by influencing Physiological, morphological molecular and biochemical traits at cellular level. It is a polygenic trait, controlled by multiple genes, which makes its manipulation difficult by genetic engineering. It seems drought could be major threat in future to high yield of cotton in Pakistan as well around the globe because it is spontaneous and cannot be controlled with manuring and skilled agricultural practices. Gene manipulation could be a solution of this threat by producing transgenic cotton plants. As it is polygenic trait, so, understanding about cellular mechanism of drought tolerance is crucial to impart tolerance by controlling gene expression under stressed conditions. Universal Stress Proteins (USP) genes have already been identified in drought stressed leaves of Gossypium arboreum which make this variety of cotton a rich source of stress tolerance genes. USP genes could be manipulated for drought tolerant transgenic cotton with high yielding as well and it is most important family of proteins in this regard. This family encompasses a conserved group of proteins that has been reported in different organisms which are activating under various abiotic stress conditions. USP is also a regulatory protein; its activity can be increased by manipulating its interactions

A new ceramide along with eight known compounds from the roots of Artemisia incisa pamp

A new compound (1) (named as artemceramide-B) together with eight known compounds (taraxerol (2), taraxerol acetate (3), β-sitosterol (4), stigmasterol (5), trans-ethyl caffeate, dracunculin (7), scoparone (8) and isoscopoletin (9) were isolated from an ethanolic extract of the roots of Artemisia incisa Pamp (Asteracae). The structures of the compounds were determined through IR, 1D NMR (1H NMR, 13C NMR) and 2D NMR (COSY, NOESY, HSQC and HMBC) analyses. Accurate mass analyses were done with EI-MS, ESI-MS and acid methanolysis of compound 1 followed by GS-MS studies. The relative stereochemistry of artemceramide-B was determined by comparing its specific rotation and spectroscopic data with the literature. Compounds 1-9 were tested for their anti-bacterial potential against five bacteria strains; Staphylococcus epidermidis, Staphylococcus aureus, Klebsiella pneumoniae, Bacillus subtilis and Escherichia coli. Compound 1 (new) (MIC: 0.0157, 0.0313 mg/mL) and 7 (MIC: 0.0815 , 1.000 mg/mL) showed excellent activities against S. epidermidis and S. aureus while compound 9 showed excellent activities (MIC: 0.0700 , 1.234, 1.890 and 2.286 mg/mL) against S. epidermidis,S. aureus, K. pneumoniae and E. coli, respectively. Compound 6 (MIC: 2.000 mg/mL) was found to be active against E. coli while neither of the compounds showed potential activity against B. subtilis

A rare association of Takotsubo cardiomyopathy with neuroleptic malignant syndrome

Neuroleptic malignant syndrome is a potentially fatal neurological condition secondary toantipsychotic medication. It is characterized by distinctive clinical findings and autonomicdisturbances. NMS has not been associated with Takotsubo cardiomyopathy (TCM). TCM is an abnormal response to physiological stressors resulting from the autonomicabnormalities which at times can mimic myocardial infarction (MI). We present a unique caseof a 54-year-old female with bipolar disease presenting with lithium and haloperidol-inducedNMS complicated by TCM. The purpose of this case is to make clinicians aware of this rareassociation

In vitro and in vivo exploitation of cell stress pathways using methanolic extracts of Phlomis stewartii in diabetic rat's model

Various bioactive constituents present in plants are used to treat metabolic disorders linked to oxidative stress and obesity. Low-grade to chronic inflammation and IR are considered as main causes of obesity, which is strongly correlated with the prevalence and incidence of Type-2 Diabetes Mellitus (T2DM). In this study, the biological influence of Phlomis stewartii extracts was evaluated in vitro and in vivo using rat diabetic models. The biological effects included anti-inflammatory, anti-proliferative, anti-apoptotic, metabolic hormonal via molecular signaling pathways, and antioxidant potential. The extracts from P. stewartii exhibited the strongest DPPH and FRAP potential for LM (38.92 µg/mL) and (45.28 µg/mL) respectively. Moreover, the high absorbance for reducing power was observed in leaves methanol (LM) 1.36 which is greater than flower methanol (FM) 1.12, and whole plant methanol (WPM) 1.21 at a concentration of 500 µg/mL when comparing treated groups to the negative control (NC), and positive control (PC) groups. The results of an Enzyme-linked Immunosorbent Assay (ELISA) study measuring a metabolic hormonal profile that includes Triiodothyronine (T3), Thyroxine (T4), Thyroid Stimulating Hormone (TSH), insulin, leptin, and glucokinase showed that LM has been greatly recovered. The study examined the gene expression analysis of cell stress pathways, and it found that the PC groups had higher levels of Janus kinase (JAK), Signal Transducer and Activator of Transcription (STATS) pathways through JAK (JAK-2 and STAT-1), G protein-Coupled Receptor Kinase 2 (GRK-2), Calmodulin 2 (CALM-2), Proteins Inhibitor of Activated STAT 1 (PIAS-1), Forkhead Box 01, 03, 04, (FOXO-1, FOXO-3, FOXO-4), Bcl-2 Associated X-protein (BAX), B-cell Lymphoma 2 (BCL-2), Interleukins (IL-6, IL-1β), and Tumour Necrosis Factor-α (TNF-α). On the other hand, downregulation was observed in NC groups and P. stewartii extract-treated groups. The outcome of this study suggests a strong relationship towards ameliorative effects.info:eu-repo/semantics/publishedVersio

Disaster Mitigation Strategies for Adobe Houses: A Case Study of District Awaran, Balochistan, Pakistan

peer reviewedEvery year disasters affect hundreds of millions of people globally causing damage that can take years to recover from. The process of rebuilding and re-establishing is vitally important to the successful continuation of life, industry and growth of affected societies and communities. Besides human casualties one of the most visible and striking effects of any major disaster is the destruction of houses. Construction of houses will be a major activity in the reconstruction phase of a disaster. The impact of disasters caused by natural hazards such as earthquakes can have serious consequences. Vulnerable populations are faced with unforeseen hardships, misery, and death if their houses and buildings collapse, and supporting infrastructure is severely damaged. Awaran District, Balochistan is one the least developed areas of Pakistan with very low Human development index (HDI). In 2013, an earthquake of Mw 7.7 occurred in the region, causing damage to the houses and human lives. The study covers the findings of the field survey for the damages occurred to the adobe houses in Awaran due to earthquake and analyse the causes of failure of the structures. It further suggests the design strategies and measures for the mitigation and prevention against these damages in order to decrease the loss to housing stock and lower the risks to human life due to failure of structures during earthquake