Ka-band MMIC beam steered transmitter array

A 32-GHz six-element linear transmitter array utilizing monolithic microwave integrated circuit (MMIC) phase shifters and power amplifiers was designed and tested as part of the development of a spacecraft array feed for NASA deep-space communications applications. Measurements of the performance of individual phase shifters, power amplifiers, and microstrip radiators were carried out, and electronic beam steering of the linear array was demonstrated. The switched-line phase shifters were accurate to within 7 percent on average and the power amplifier 1-dB compressed output power varied over 0.3 dB. The array had a beamwidth of 7.5 deg and demonstrated acceptable beam steering over + or - 8 deg. From the results, it can be concluded that this MMIC phased array has adequate beam-scanning capability for use in the two-dimensional array. The areas that need to be improved are the efficiency of the MMIC power amplifier and the insertion loss of the MMIC phase shifter

A 32-GHz phased array transmit feed for spacecraft telecommunications

A 21-element phased array transmit feed was demonstrated as part of an effort to develop and evaluate state-of-the-art transmitter and receiver components at 32 and 34 GHz for future deep-space missions. Antenna pattern measurements demonstrating electronic beam steering of the two-dimensional array are reported and compared with predictions based on measured performance of MMIC-based phase shifter and amplifier modules and Vivaldi slotline radiating elements

A 32-GHz solid-state power amplifier for deep space communications

A 1.5-W solid-state power amplifier (SSPA) has been demonstrated as part of an effort to develop and evaluate state-of-the-art transmitter and receiver components at 32 and 35 GHz for future deep space missions. Output power and efficiency measurements for a monolithic millimeter-wave integrated circuit (MMIC)-based SSPA are reported. Technical design details for the various modules and a thermal analysis are discussed, as well as future plans

The inhibition of FGF receptor 1 activity mediates sorafenib-induced antiproliferative effects in human mesothelioma tumor-initiating cells

Tumor-initiating cells (TICs), the subset of cells within tumors endowed with stem-like features, being highly resistant to conventional cytotoxic drugs, are the major cause of tumor relapse. The identification of molecules able to target TICs remains a significant challenge in cancer therapy. Using TIC-enriched cultures (MM1, MM3 and MM4), from 3 human malignant pleural mesotheliomas (MPM), we tested the effects of sorafenib on cell survival and the intracellular mechanisms involved. Sorafenib inhibited cell-cycle progression in all the TIC cultures, but only in MM3 and MM4 cells this effect was associated with induction of apoptosis via the down-regulation of Mcl-1. Although sorafenib inhibits the activity of several tyrosine kinases, its effects are mainly ascribed to Raf inhibition. To investigate the mechanisms of sorafenib-mediated antiproliferative activity, TICs were treated with EGF or bFGF causing, in MM3 and MM4 cells, MEK, ERK1/2, Akt and STAT3 phosphorylation. These effects were significantly reduced by sorafenib in bFGF-treated cells, while a slight inhibition occurred after EGF stimulation, suggesting that sorafenib effects are mainly due to FGFR inhibition. Indeed, FGFR1 phosphorylation was inhibited by sorafenib. A different picture was observed in MM1 cells, which, releasing high levels of bFGF, showed an autocrine activation of FGFR1 and a constitutive phosphorylation/activation of MEK-ERK1/2. A powerful inhibitory response to sorafenib was observed in these cells, indirectly confirming the central role of sorafenib as FGFR inhibitor. These results suggest that bFGF signaling may impact antiproliferative response to sorafenib of MPM TICs, which is mainly mediated by a direct FGFR targeting

A Study of Parton Fragmentation in Hadronic Z0 Decays Using Lambda-Lambdabar Correlations

The correlated production of Lambda and Lambdabar baryons has been studied using 4.3 million multihadronic Zo decays recorded with the OPAL detector at LEP. Di-lambda pairs were investigated in the full data sample and for the first time also in 2-jet and 3-jet events selected with the k_t algorithm. The distributions of rapidity differences from correlated Lambda-Lambdabar pairs exhibit short-range, local correlations and prove to be a sensitive tool to test models, particularly for 2-jet events. The JETSET model describes the data best but some extra parameter tuning is needed to improve agreement with the experimental results in the rates and the rapidity spectra simultaneously. The recently developed modification of JETSET, the MOdified Popcorn Scenarium (MOPS), and also HERWIG do not give satisfactory results. This study of di-lambda production in 2- and 3-jet events supports the short-range compensation of quantum numbers.Comment: 23 pages, LaTeX, 6 figures included plus 1 in colour, submitted to Physics Letters

Comparative Study of Optical and Radio-Frequency Communication Systems for a Deep-Space Mission

We have performed a study on telecommunication systems for a hypothetical mission to Mars. The objective of the study was to evaluate and compare the benefits that microwave-X-band (8.4 GHz) and Ka-band (32 GHz) - and optical communications technologies a afford to future missions. The telecommunication systems were required to return data after launch and in orbit at 2.7 AU with daily data volumes of 0.1, 1.0, or 10.0 Gbits (Gb). Spacecraft terminals capable of delivering each of the three data volumes were proposed and characterized in terms of mass, power consumption, size, and cost. The estimated parameters for X-band, Ka-band, and optical frequencies are compared and presented here. For all cases, the optical light terminal exhibits about 60 percent of the mass of the corresponding radio frequency (RF) subsystem. Power consumption is comparable for all three technologies at a 0.1 Gb/day data volume, but the power required at either Ka-band or optical is less than half of the X-band requirement at 10 Gb/day. These benefits can be obtained only with a suitable investment in reception facilities for Ka-band or optical frequencies