F-15 composite engine access door

This paper presents a summary of the successfully concluded phase 1 of the two-phase Design and Manufacture of Advanced Thermoplastic Structures (DMATS) program. It addresses the design, manufacture, and validation testing of a thermoplastic F-15E forward engine access door and includes lessons learned during the concurrent product and process design development phases of the program

Sensitivity Analysis for Shortest Path Problems and Maximum Capacity Path Problems in Undirected Graphs

This paper addresses sensitivity analysis questions concerning the shortest path problem and the maximum capacity path problem in an undirected network. For both problems, we determine the maximum and minimum weights that each edge can have so that a given path remains optimal. For both problems, we show how to determine these maximum and minimum values for all edges in O(m + K log K) time, where m is the number of edges in the network, and K is the number of edges on the given optimal path

Ameliorating Direct Blue Dye Degradation Using Trametes versicolor Derived Laccase Enzyme Optimized through Box–Behnken Design (BBD) via Submerged Fermentation

The major intend of this study was to elucidate the laccase production by Trametes versicolor under submerged fermentation using fruit waste peel as substrate. The textile dye was decolorized by the procured crude enzymatic extract using the response surface methodology. The submerged media with organic fruit peel waste extract (jackfruit, pineapple & kaffir) supplemented with gypsum, calcium carbonate, and nutrient broth were considered superior for laccase production. The produced laccase enzyme was used in dye decolorization at the optimum conditions using the Box-Behnken design. Subsequently, the experiment was designed with four variables (dye concentration, pH, temperature & time) with three factors to achieve the maximum direct blue dye decolorization. The highest laccase activity level was obtained from jackfruit peel extract with 3.86U/ml on 15th day at 25oC with pH 5.0 when compared to the other two extracts. The maximum laccase activity with guaiacol was obtained at optimum pH 4 and 40oC. The predicted value was experimentally validated by attaining 81.25% of dye color removal. From the result, the optimum conditions for direct blue color removal were: dye concentration 40ppm, pH 4.0, temperature 40oC at 24 hours. From the results of this study, it was concluded that the jack fruit peel was a more suitable substrate for laccase production. The dye decolorization results were recommended that Box-Behnken design for parameters optimization. The T. versicolor laccase was more proficient for textile dye decolorization. The opportunity was created by using the laccase enzyme for the biological treatment of textile dyeing effluent before discharging into the environment

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly

Probabilistic Application-Level Connection Scheduling in Web Servers

A Web server running a popular Web site might simultaneously service hundreds or even thousands of requests. Many traditional Web servers let the operating system decide the connection scheduling—that is, the order in which requests are serviced—and, in fact, most simply do so on a first-come, first-served basis. In many cases, however, it can be extremely useful, if not downright necessary, to have application-level control over scheduling policies. Application-level connection scheduling lets server administrators specify the scheduling rules they want to impose, rather than relying on programmers to do it. Two obvious cases where this might be useful are: • When different users have different priorities. To determine request priority for different user groups, you can use business rules to determine processing order. This lets you provide differentiated quality of service levels to different clients. • When Web server traffic is bursty. For example, the average peak-hour traffic is typically several times the average daily traffic. Rather than overprovision the server, you can turn to differentiated QoS as a more judicious approach to resource use under high-load conditions. Application-level connection scheduling also offers another benefit that is rathe

Sensitivity Analysis for Shortest Path Problems and Maximum Capacity Path Problems in Undirected Graphs

This paper addresses sensitivity analysis questions concerning the shortest path problem and the maximum capacity path problem in an undirected network. For both problems, we determine the maximum and minimum weights that each edge can have so that a given path remains optimal. For both problems, we show how to determine these maximum and minimum values for all edges in O(m + K log K) time, where m is the number of edges in the network, and K is the number of edges on the given optimal path.sensitivity analysis, shortest path problem, bottleneck shortest path, maximum capacity path problem,