Review of Softly As I Leave You by Chandani Lokuge

Review of Softly As I Leave You by Chandani Lokug

A new synthesis of maltol

M.S.John R. Dye

Higher congruence companion forms

For a rational prime p � 3 we consider p-ordinary, Hilbert modular newforms f of weight k � 2 with associated p-adic Galois representations �f and mod pn reductions �f;n. Under suitable hypotheses on the size of the image, we use deformation theory and modularity lifting to show that if the restrictions of �f;n to decomposition groups above p split then f has a companion form g modulo pn (in the sense that �f;n � �g;n �

EVM as generic QoS trigger for heterogeneous wieless overlay network

Fourth Generation (4G) Wireless System will integrate heterogeneous wireless overlay systems i.e. interworking of WLAN/ GSM/ CDMA/ WiMAX/ LTE/ etc with guaranteed Quality of Service (QoS) and Experience (QoE).QoS(E) vary from network to network and is application sensitive. User needs an optimal mobility solution while roaming in Overlaid wireless environment i.e. user could seamlessly transfer his session/ call to a best available network bearing guaranteed Quality of Experience. And If this Seamless transfer of session is executed between two networks having different access standards then it is called Vertical Handover (VHO). Contemporary VHO decision algorithms are based on generic QoS metrics viz. SNR, bandwidth, jitter, BER and delay. In this paper, Error Vector Magnitude (EVM) is proposed to be a generic QoS trigger for VHO execution. EVM is defined as the deviation of inphase/ quadrature (I/Q) values from ideal signal states and thus provides a measure of signal quality. In 4G Interoperable environment, OFDM is the leading Modulation scheme (more prone to multi-path fading). EVM (modulation error) properly characterises the wireless link/ channel for accurate VHO decision. EVM depends on the inherent transmission impairments viz. frequency offset, phase noise, non-linear-impairment, skewness etc. for a given wireless link. Paper provides an insight to the analytical aspect of EVM & measures EVM (%) for key management subframes like association/re-association/disassociation/ probe request/response frames. EVM relation is explored for different possible NAV-Network Allocation Vectors (frame duration). Finally EVM is compared with SNR, BER and investigation concludes EVM as a promising QoS trigger for OFDM based emerging wireless standards.Comment: 12 pages, 7 figures, IJWMN 2010 august issue vol. 2, no.

A characterization of ordinary modular eigenforms with CM

For a rational prime $p \geq 3$ we show that a $p$-ordinary modular eigenform $f$ of weight $k\geq 2$, with $p$-adic Galois representation $\rho_f$, mod ${p^m}$ reductions $\rho_{f,m}$, and with complex multiplication (CM), is characterized by the existence of $p$-ordinary CM companion forms $h_m$ modulo $p^m$ for all integers $m \geq 1$ in the sense that $\rho_{f,m}\sim \rho_{h_m,m}\otimes\chi^{k-1}$, where $\chi$ is the $p$-adic cyclotomic character.Comment: 9 pages. Elementary proof of the main theorem added in Section

Higher congruence companion forms

For a rational prime $p \geq 3$ we consider $p$-ordinary, Hilbert modular newforms $f$ of weight $k\geq 2$ with associated $p$-adic Galois representations $\rho_f$ and $\mod{p^n}$ reductions $\rho_{f,n}$. Under suitable hypotheses on the size of the image, we use deformation theory and modularity lifting to show that if the restrictions of $\rho_{f,n}$ to decomposition groups above $p$ split then $f$ has a companion form $g$ modulo $p^n$ (in the sense that $\rho_{f,n}\sim \rho_{g,n}\otimes\chi^{k-1}$).Comment: 13 page

QSAR studies on Withanolide analogs for anticancer activity

Withanolides are a group of pharmacologically active compounds present in most prodigal amounts in roots and leaves of Withania somnifera (Indian ginseng), one of the most important medicinal plants of Indian systems of medicine. Withanolides are basically steroidal lactones (highly oxygenated C-28 phytochemicals) and similar to ginsenosides activity. Some of the withanolides that have been reported possess immunomodulatory, and anticancer activities. In the present investigation, a quantitative structure activity relationship (QSAR) model based on forward stepwise multiple linear regression (MLR) has been developed against the MCF7, MCF7/BUS, and SK-Br-3 human solid tumor breast cancer cell lines. Relationship correlation coefficient (r2) and cross validation correlation coefficient (r2CV) of QSAR model were 0.77 and 0.73 for MCF7, 0.91 and 0.85 for MCF7/BUS, 0.93 and 0.90 for SK-Br-3 respectively. Developed QSAR model was also evaluated for prediction accuracy through internal, external and randomization validation methods. The QSAR study indicates that chemical descriptors viz., atom count (all atoms), connectivity index (order 2, standard), for MCF7, Connectivity Index (order 0, standard), Dipole Vector X (debye), Molar Refractivity, Shape Index (basic kappa, order 2) for SK-Br-3 and Atom Count (all atoms), Dielectric Energy (kcal/mole), Total Energy (Hartree), Heat of Formation (kcal/mole) for MCF7/BUS are correlate well with the breast cancer activity, Moreover, on the basis of screening for oral bioavailability, in silico ADME and toxicity risk assessment, we concluded that compounds W3, W4, W8 have markedly higher anticancer activity compared to control. These results can offer useful references for directing the molecular design of lead compound(s) based on withanolide or analogous template with improved activity

Identification and validation of genomic regions associated with pre-harvest sprouting resistance in white-grained wheat (triticum aestivum L.)

Pre-harvest sprouting (PHS) in bread wheat (Triticum aestivum L.) is one of the major abiotic constraints influencing the production of high quality grain. The flour milled from sprouted wheat grains has increased Ą-amylase activity as compared to non-sprouted grain. PHS negatively affects the properties of flour with deleterious effects on bread and noodle quality. White-grained wheat is generally more susceptible to PHS damage than red-grained wheat. The objectives of this study were to identify a suitable method for phenotyping PHS resistance and to identify PHS resistance genomic regions and markers that could be used for marker-assisted selection in wheat improvement programs. A doubled haploid (DH) mapping population from a cross between two white-grained spring wheat genotypes, Argent (non-dormant) and W98616 (dormant) was used in this study. Forty DH lines (20 dormant and 20 non-dormant) were evaluated for germination frequency, Falling Number, and Ą-amylase activity in dry and water-imbibed seeds and spikes. The germination test was the most reliable method for measurement of PHS resistance, whereas the Falling Number and Ą-amylase activity in dry harvested seeds could not be correlated to dormancy levels. However, a positive association (r = 0.60***) was detected between germination frequency and Ą-amylase activity in imbibed seeds. To identify the genomic regions associated with PHS resistance, a genetic linkage map with a total genome coverage of 2,577 cM was developed. The map was constructed from 913 scored markers (356 SSR, 290 AFLP, 258 DArT and 9 EST) with an average marker density of 3.7 cM/marker. Five genomic regions on chromosomes 1A, 3A, 4A, 7A and 7D were associated with PHS resistance by interval mapping and all regions were contributed by the dormant parent W98616. A total of 60 Canadian wheat cultivars and experimental lines were screened with three SSR markers, DuPw004, barc170 and wmc650, located under the major quantitative trait locus (QTL) on chromosome 4A. The SSR markers explained 60-75% of the total variation in germination frequency among different wheat genotypes. By using the DuPw004 marker in marker-assisted back crossing, the population size in the BC1F1 and BC2F1 generations were reduced by 41% and 59%, respectively. Thus, the 4A QTL markers have been proven useful for marker-assisted selection of PHS resistance for wheat improvement

Review of A God in Every Stone by Kamila Shamsie

Review of A God in Every Stone by Kamila Shamsi