Neuromedin U receptors in GtoPdb v.2023.1

Neuromedin U receptors (provisional nomenclature as recommended by NC-IUPHAR [30]) are activated by the endogenous 25 amino acid peptide neuromedin U (neuromedin U-25, NmU-25), a peptide originally isolated from pig spinal cord [92]. In humans, NmU-25 appears to be the sole product of a precursor gene (NMU, P48645) showing a broad tissue distribution, but which is expressed at highest levels in the upper gastrointestinal tract, CNS, bone marrow and fetal liver. Much shorter versions of NmU are found in some species, but not in human, and are derived at least in some instances from the proteolytic cleavage of the longer NmU. Despite species differences in NmU structure, the C-terminal region (particularly the C-terminal pentapeptide) is highly conserved and contains biological activity. Neuromedin S (neuromedin S-33) has also been identified as an endogenous agonist [97]. NmS-33 is, as its name suggests, a 33 amino-acid product of a precursor protein derived from a single gene and contains an amidated C-terminal heptapeptide identical to NmU. NmS-33 appears to activate NMU receptors with equivalent potency to NmU-25

Neuromedin U receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Neuromedin U receptors (provisional nomenclature as recommended by NC-IUPHAR [29]) are activated by the endogenous 25 amino acid peptide neuromedin U (neuromedin U-25, NmU-25), a peptide originally isolated from pig spinal cord [90]. In humans, NmU-25 appears to be the sole product of a precursor gene (NMU, P48645) showing a broad tissue distribution, but which is expressed at highest levels in the upper gastrointestinal tract, CNS, bone marrow and fetal liver. Much shorter versions of NmU are found in some species, but not in human, and are derived at least in some instances from the proteolytic cleavage of the longer NmU. Despite species differences in NmU structure, the C-terminal region (particularly the C-terminal pentapeptide) is highly conserved and contains biological activity. Neuromedin S (neuromedin S-33) has also been identified as an endogenous agonist [95]. NmS-33 is, as its name suggests, a 33 amino-acid product of a precursor protein derived from a single gene and contains an amidated C-terminal heptapeptide identical to NmU. NmS-33 appears to activate NMU receptors with equivalent potency to NmU-25

Carbon-concentration and carbon-climate feedbacks in CMIP6 models, and their comparison to CMIP5 models

Abstract. Results from the fully-, biogeochemically-, and radiatively-coupled simulations in which CO2 increases at a rate of 1 % per year (1pctCO2) from its pre-industrial value are analyzed to quantify the magnitude of two feedback parameters which characterize the coupled carbon-climate system. These feedback parameters quantify the response of ocean and terrestrial carbon pools to changes in atmospheric CO2 concentration and the resulting change in global climate. The results are based on eight comprehensive Earth system models from the fifth Coupled Model Intercomparison Project (CMIP5) and eleven models from the sixth CMIP (CMIP6). The comparison of model results from two CMIP phases shows that, for both land and ocean, the model mean values of the feedback parameters and their multi-model spread has not changed significantly across the two CMIP phases. The absolute values of feedback parameters are lower for land with models that include a representation of nitrogen cycle. The sensitivity of feedback parameters to the three different ways in which they may be calculated is shown and, consistent with existing studies, the most relevant definition is that calculated using results from the fully- and biogeochemically-coupled configurations. Based on these two simulations simplified expressions for the feedback parameters are obtained when the small temperature change in the biogeochemically-coupled simulation is ignored. Decomposition of the terms of these simplified expressions for the feedback parameters allows identification of the reasons for differing responses among ocean and land carbon cycle models. </jats:p

Carbon-concentration and carbon-climate feedbacks in CMIP6 models, and their comparison to CMIP5 models

Abstract. Results from the fully-, biogeochemically-, and radiatively-coupled simulations in which CO2 increases at a rate of 1 % per year (1pctCO2) from its pre-industrial value are analyzed to quantify the magnitude of two feedback parameters which characterize the coupled carbon-climate system. These feedback parameters quantify the response of ocean and terrestrial carbon pools to changes in atmospheric CO2 concentration and the resulting change in global climate. The results are based on eight comprehensive Earth system models from the fifth Coupled Model Intercomparison Project (CMIP5) and eleven models from the sixth CMIP (CMIP6). The comparison of model results from two CMIP phases shows that, for both land and ocean, the model mean values of the feedback parameters and their multi-model spread has not changed significantly across the two CMIP phases. The absolute values of feedback parameters are lower for land with models that include a representation of nitrogen cycle. The sensitivity of feedback parameters to the three different ways in which they may be calculated is shown and, consistent with existing studies, the most relevant definition is that calculated using results from the fully- and biogeochemically-coupled configurations. Based on these two simulations simplified expressions for the feedback parameters are obtained when the small temperature change in the biogeochemically-coupled simulation is ignored. Decomposition of the terms of these simplified expressions for the feedback parameters allows identification of the reasons for differing responses among ocean and land carbon cycle models. </jats:p

Silver Nanorods As Indicators of Thermal History (Semester Unknown) IPRO 348: SilverNanorodsAsIndicatorsOfThermalHistoryIPRO348ProjectPlanSp10

Silver Nanorods As Indicators of Thermal History, heat pum, NaOH,Deliverable

Silver Nanorods As Indicators of Thermal History (Semester Unknown) IPRO 348

Silver Nanorods As Indicators of Thermal History, heat pum, NaOH,Deliverable

Silver Nanorods As Indicators of Thermal History (Semester Unknown) IPRO 348: SilverNanorodsAsIndicatorsOfThermalHistoryIPRO348FinalReportSp10

Silver Nanorods As Indicators of Thermal History, heat pum, NaOH,Deliverable

Silver Nanorods As Indicators of Thermal History (Semester Unknown) IPRO 348: SilverNanorodsAsIndicatorsOfThermalHistoryIPRO348PosterSp10

Silver Nanorods As Indicators of Thermal History, heat pum, NaOH,Deliverable