4 research outputs found
A Survey of Semantic Integration Approaches in Bioinformatics
Technological advances of computer science and data
analysis are helping to provide continuously huge volumes of
biological data, which are available on the web. Such advances
involve and require powerful techniques for data integration to
extract pertinent knowledge and information for a specific question.
Biomedical exploration of these big data often requires the use
of complex queries across multiple autonomous, heterogeneous
and distributed data sources. Semantic integration is an active
area of research in several disciplines, such as databases,
information-integration, and ontology. We provide a survey of some
approaches and techniques for integrating biological data, we focus
on those developed in the ontology community
TRANSLATION METHODOLOGY BASED ON META- MODEL OF COMPLEX STRUCTURE FOR DATABASE DESIGN
ABSTRACT We propose a software layer called GUEDOS-DB upon Object-Relational Database Management System ORDMS. In this work we apply it in Molecular Biology, more precisely Organelle (mitochondria and chloroplasts) complete genome. We aim to offer biologists the possibility to access in a unified way information spread among heterogeneous genome databanks. In this paper, the goal is firstly, to provide a visual schema graph through a number of illustrative examples. The adopted, human-computer interaction technique in this visual designing and querying makes very easy for biologists to formulate database queries compared with linear textual query representation
Measurement of nonlinear pO 2 decay in mouse lungs using 3 He-MRI
ABSTRACT: Spatial and temporal variations in oxygen partial pressure ( pO 2 ) during breath-hold can be exploited to obtain important regional parameters of lung function. In the course of apnea, the oxygen concentration is known to decay exponentially. Therefore, the initial pO 2 ( p 0 ) can be used to represent local ventilation, and the oxygen depletion time constant can characterize perfusion. The protocol, based on a nonlinear model of pO 2 decay, was validated in six healthy mice. Parametric maps of p 0 and oxygen depletion time constant were obtained for pure He/air mixture, in agreement with physiology