Las damas del mar. Viajeras, emigrantes, literatas y artistas desde y hacia el cono Sur en los siglos XIX y XX

Este proyecto se desarrolla en forma conjunta entre investigadores argentinos e italianos. Se analizan obras de escritoras y artistas de los siglos XIX y XX, de sendas nacionalidades, en relación con la problemática inmigratoria y la construcción de una identidad femenina cimentada a lo largo del diálogo entre dos riberas: la mediterránea y la rioplatense. Las investigadoras argentinas se ocupan de la obra de Eduarda Mansilla, viajera y nómade, que inició un derrotero continuado por otras mujeres argentinas destacadas en la literatura y en las artes. Entre ellas se distinguen Victoria Ocampo y Sara Gallardo en las letras, y Lola Mora, en las artes plásticas. Por su parte, los investigadores italianos, se centran en los mecanismos de elaboración de la experiencia migratoria en la narrativa italiana y argentina escrita por mujeres desde los años cincuenta del siglo XX hasta nuestros días, según dos líneas principales: narrativas de segundo grado directo (S. Poletti, G. Gambaro, M. T. Andruetto), escritas por narradoras de segunda generación, que escriben desde un locus diferente del originario (suyo o de sus antepasados inmigrantes); narrativas de segundo grado indirecto (M. Sedda, R. Mambelli, R. Petri), que tematizan historias de vida entre Italia y Argentina, sin que sus autoras tengan experiencia propia o familiar de la migración. Estudian el diálogo simbólico que estas narrativas entrelazan y su aporte a la construcción de un imaginario migratorio memorable y memorializable.This project is developed by Argentine and Italian researchers jointly. There are analyze the works of women writers as well as visual artists from 19th and 20th centuries, coming from diverse nationalities, regarding to the immigration problems and the construction of and feminine identity, consolidated through the dialogue between two banks: the Mediterranean’s and the Río de La Plata’s sides. On the one hand, Argentine researchers study Eduarda Mansilla’s work, traveller and nomad,who prepared the way for others argentines women outstanded at Literature (Victoria Ocampo andSara Gallardo) and at Arts (Lola Mora). On the other hand, Italian researchers focus on the elaborationprocess of migratory experience at the Italian and Argentine narrative, written by women,since 1950s till nowadays, according to two main groups: direct narratives of second degree (S.Poletti, G. Gambaro, M. T. Andruetto), written by second generation narrators, who build their storiesfrom a locus different to the original one (hers or her immigrant ancestors); indirect narrativesof second degree (M. Sedda, R. Mambelli, R. Petri), which thematize life stories between Italy andArgentina, even when their authors haven’t experienced their own or family migration. All of themstudy the symbolic dialogue set up among these narratives and its contribution to the consolidationof a migratory imaginary, memorable and memoralizable

Health-status outcomes with invasive or conservative care in coronary disease

BACKGROUND In the ISCHEMIA trial, an invasive strategy with angiographic assessment and revascularization did not reduce clinical events among patients with stable ischemic heart disease and moderate or severe ischemia. A secondary objective of the trial was to assess angina-related health status among these patients. METHODS We assessed angina-related symptoms, function, and quality of life with the Seattle Angina Questionnaire (SAQ) at randomization, at months 1.5, 3, and 6, and every 6 months thereafter in participants who had been randomly assigned to an invasive treatment strategy (2295 participants) or a conservative strategy (2322). Mixed-effects cumulative probability models within a Bayesian framework were used to estimate differences between the treatment groups. The primary outcome of this health-status analysis was the SAQ summary score (scores range from 0 to 100, with higher scores indicating better health status). All analyses were performed in the overall population and according to baseline angina frequency. RESULTS At baseline, 35% of patients reported having no angina in the previous month. SAQ summary scores increased in both treatment groups, with increases at 3, 12, and 36 months that were 4.1 points (95% credible interval, 3.2 to 5.0), 4.2 points (95% credible interval, 3.3 to 5.1), and 2.9 points (95% credible interval, 2.2 to 3.7) higher with the invasive strategy than with the conservative strategy. Differences were larger among participants who had more frequent angina at baseline (8.5 vs. 0.1 points at 3 months and 5.3 vs. 1.2 points at 36 months among participants with daily or weekly angina as compared with no angina). CONCLUSIONS In the overall trial population with moderate or severe ischemia, which included 35% of participants without angina at baseline, patients randomly assigned to the invasive strategy had greater improvement in angina-related health status than those assigned to the conservative strategy. The modest mean differences favoring the invasive strategy in the overall group reflected minimal differences among asymptomatic patients and larger differences among patients who had had angina at baseline

Initial invasive or conservative strategy for stable coronary disease

BACKGROUND Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than in those who receive medical therapy alone is uncertain. METHODS We randomly assigned 5179 patients with moderate or severe ischemia to an initial invasive strategy (angiography and revascularization when feasible) and medical therapy or to an initial conservative strategy of medical therapy alone and angiography if medical therapy failed. The primary outcome was a composite of death from cardiovascular causes, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. A key secondary outcome was death from cardiovascular causes or myocardial infarction. RESULTS Over a median of 3.2 years, 318 primary outcome events occurred in the invasive-strategy group and 352 occurred in the conservative-strategy group. At 6 months, the cumulative event rate was 5.3% in the invasive-strategy group and 3.4% in the conservative-strategy group (difference, 1.9 percentage points; 95% confidence interval [CI], 0.8 to 3.0); at 5 years, the cumulative event rate was 16.4% and 18.2%, respectively (difference, 121.8 percentage points; 95% CI, 124.7 to 1.0). Results were similar with respect to the key secondary outcome. The incidence of the primary outcome was sensitive to the definition of myocardial infarction; a secondary analysis yielded more procedural myocardial infarctions of uncertain clinical importance. There were 145 deaths in the invasive-strategy group and 144 deaths in the conservative-strategy group (hazard ratio, 1.05; 95% CI, 0.83 to 1.32). CONCLUSIONS Among patients with stable coronary disease and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of ischemic cardiovascular events or death from any cause over a median of 3.2 years. The trial findings were sensitive to the definition of myocardial infarction that was used